A new effective on chip electromembrane extraction coupled with high performance liquid chromatography for enhancement of extraction efficiency

2015 ◽  
Vol 898 ◽  
pp. 42-49 ◽  
Author(s):  
Yousef Abdossalami Asl ◽  
Yadollah Yamini ◽  
Shahram Seidi ◽  
Behnam Ebrahimpour
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Extraction Efficiency ◽  
Electromembrane Extraction ◽  
On Chip

scholarly journals Estimation of Some Useful Drugs in Water, Urine, and Medical Formulations Following Conventional and Modified Dispersive Microextraction Coupled with HPLC-UV

2021 ◽  
pp. 11-33
Author(s):  
Mitali Sarkar ◽  
Shanku Denrah
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Extraction Efficiency ◽  
Sodium Dodecyl ◽  
Two Phase ◽  
Preconcentration Factor ◽  
Dispersive Microextraction ◽  
Dispersive Liquid Liquid Microextraction ◽  
Thermodynamic Feasibility

Dispersive Liquid-Liquid Microextraction (DLLME) coupled with high-performance liquid chromatography-ultraviolet spectroscopy was developed, as a fast and precise operation, for extractive recovery and estimation of two pharmaceuticals viz. moxifloxacin and galantamine, from water, urine, and medical formulations. The process was investigated for Extraction (ES) and Dispersive Solvent (DS) as well as pH, temperature, and salt concentration. Extraction was found effective using methanol (CH3OH), as the DS, employing 1,1,2,2-tetrachloroethane (C2H2Cl4) and chloroform (CHCl3), as the ES, for moxifloxacin and galantamine respectively. The optimum pH was found to be 6.9 for moxifloxacin and 10.2 for galantamine. Temperature and salt were found to have some influence on the extraction efficiency of moxifloxacin but insignificant for galantamine. An improvement of the operation in terms of the Extraction efficiency (ER %), Preconcentration Factor (PF), thermodynamic feasibility, and greenness were achieved during surfactant aided DLLME (SDS-DLLME), where anionic surfactant (Sodium Dodecyl Sulphate (SDS)) was employed and no DS was required. Interestingly, the volume requirement for ES was found less, compared to that in the conventional DLLME, without compromising the performance. Moreover, quantitative recovery of both the drugs was achieved using a single ES. Thus, mutual separation and simultaneous determination of moxifloxacin and galantamine may be designed. A two-phase separation with concomitant enrichment of the solute in the sediment phase occurred. The drugs in the sediment phase, on subsequent dilution with methanol, were determined using the High Performance Liquid Chromatography-Ultraviolet (HPLC-UV) system. The negative free energy changes for the operation indicated that the process was thermodynamically feasible. The process was found to be effective for the spiked recovery of the studied drugs from real samples viz, water, human urine, and commercial medical formulations.

scholarly journals High-Pressure Open-Channel On-Chip Electroosmotic Pump for Nanoflow High Performance Liquid Chromatography

2014 ◽  
Vol 86 (4) ◽  
pp. 1958-1964 ◽  
Author(s):  
Wei Wang ◽  
Congying Gu ◽  
Kyle B. Lynch ◽  
Joann J. Lu ◽  
Zhengyu Zhang ◽  
...  
Keyword(s):  
High Pressure ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Open Channel ◽  
Electroosmotic Pump ◽  
On Chip

Evaluation of pulsed electromembrane extraction for the analysis of diclofenac and mefenamic acid in biological fluids

2015 ◽  
Vol 7 (6) ◽  
pp. 2848-2854 ◽  
Author(s):  
Lida Fotouhi ◽  
Shahram Seidi ◽  
Yadollah Yamini ◽  
Elham Hosseini
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Mefenamic Acid ◽  
High Performance ◽  
Biological Fluids ◽  
Acidic Drugs ◽  
Electromembrane Extraction

In the present study, electromembrane extraction (EME) and pulsed electromembrane extraction (PEME) coupled with high-performance liquid chromatography (HPLC) were compared for the extraction of two acidic drugs including diclofenac (DIC) and mefenamic acid (MEF).

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