A fluorescent and chemiluminescent difunctional mesoporous silica nanoparticle as a label for the ultrasensitive detection of cancer cells

2013 ◽  
Vol 761 ◽  
pp. 194-200 ◽  
Author(s):  
Liang Tao ◽  
Chaojun Song ◽  
Yuanjie Sun ◽  
Xiaohua Li ◽  
Yunyun Li ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cancer Cells ◽  
Silica Nanoparticle ◽  
Ultrasensitive Detection ◽  
Mesoporous Silica Nanoparticle

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

Quantum Dot-Peptide Nanoassembly on Mesoporous Silica Nanoparticle for Biosensing

2018 ◽  
Vol 19 ◽  
pp. 55-72
Author(s):  
Sreenadh Sasidharan Pillai ◽  
Hiroshi Yukawa ◽  
Daisuke Onoshima ◽  
Vasudevanpillai Biju ◽  
Yoshinobu Baba
Keyword(s):  
Quantum Dots ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Silica Nanoparticle ◽  
Fluorescent Dye ◽  
Mesoporous Silica Nanoparticle ◽  
Time Resolved ◽  
Time Resolved Photoluminescence ◽  
Targeted Detection ◽  
Dye Molecule

Quantum dots (QDs) are powerful luminescent probes for detecting single-molecules and imaging live cells. Despite several reports on bioimaging and biosensing applications of QDs, controlled and targeted detection of biomolecules using quantum dots is an ongoing challenge. When a QD is conjugated with an ideal chromophore, which can be a fluorescent or a non-fluorescent dye molecule, QD luminescence can be quenched by Förster resonance energy transfer (FRET) to the quencher dye. However, the photoluminescence of QD can be recovered upon on-demand release of the quencher. Our study focuses on quenching of QD photoluminescence after conjugation with a non-fluorescent dye molecule, black hole quencher 1 (BHQ-1), intermediated with a molecular sensing target peptide GPLG↓VRGK. Based on steady-state and time-resolved photoluminescence measurements of QD and the QD-peptide-BHQ-1 sensor assemblies, we attribute the quenching of photoluminescence intensity and lifetime to FRET from the QD to BHQ-1molecules. Here the intermediate peptide GPLG↓VRGK can be cleaved by matrix metalloproteinase-2 (MMP-2), an enzyme that is upregulated in cancer cells extra cellular matrix (ECM), at its Gly and Val region shown by the down headed arrow. Here the QD-pep-BHQ-1 conjugate detected the MMP-2 presence at the extra cellular matrix of H1299 cancer cells. Further the QD-pep-BHQ-1 molecules were conjugated at the surface of a mesoporous silica nanoparticle (MSN) scaffold to localize maximum target peptide in a nanospace volume for the future αvβ3 integrin receptor targeted detection of MMP-2. The luminescence quenching of MSN-QD-pep-BHQ-1 conjugates were analyzed with time resolved photoluminescence measurement.

scholarly journals Delivery of Ricin Toxin A-Chain by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers

2012 ◽  
Vol 1 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Katharine Epler ◽  
David Padilla ◽  
Genevieve Phillips ◽  
Peter Crowder ◽  
Robert Castillo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Lipid Bilayers ◽  
Silica Nanoparticle ◽  
Supported Lipid Bilayers ◽  
Toxin A ◽  
Mesoporous Silica Nanoparticle ◽  
Ricin Toxin ◽  
A Chain

scholarly journals Mechanism of Mesoporous Silica Nanoparticle Interaction with Hairy Root Cultures during Nanoharvesting of Biomolecules

2021 ◽  
pp. 2000173
Author(s):  
Md Arif Khan ◽  
Madeleine Fugate ◽  
Dennis T. Rogers ◽  
Jatinder Sambi ◽  
John M. Littleton ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Hairy Root ◽  
Silica Nanoparticle ◽  
Hairy Root Cultures ◽  
Root Cultures ◽  
Mesoporous Silica Nanoparticle
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