Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells

2012 ◽  
Vol 1 (5) ◽  
pp. 567-572 ◽  
Author(s):  
Le-Le Li ◽  
Qian Yin ◽  
Jianjun Cheng ◽  
Yi Lu
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

scholarly journals An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells

Oncotarget ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 1193-1208 ◽  
Author(s):  
Lakshminarasimhan Harini ◽  
Sweta Srivastava ◽  
George Peter Gnanakumar ◽  
Bose Karthikeyan ◽  
Cecil Ross ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Mcf 7

scholarly journals Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chandran Murugan ◽  
Kathirvel Rayappan ◽  
Ramar Thangam ◽  
Ramasamy Bhanumathi ◽  
Krishnamurthy Shanthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Structural Changes ◽  
Silica Nanoparticle ◽  
Therapeutic Effects ◽  
Multiple Drugs

Abstract Combination therapy of multiple drugs through a single system is exhibiting high therapeutic effects. We investigate nanocarrier mediated inhibitory effects of topotecan (TPT) and quercetin (QT) on triple negative breast cancer (TNBC) (MDA-MB-231) and multi drug resistant (MDR) type breast cancer cells (MCF-7) with respect to cellular uptake efficiency and therapeutic mechanisms as in vitro and in vivo. The synthesized mesoporous silica nanoparticle (MSN) pores used for loading TPT; the outer of the nanoparticles was decorated with poly (acrylic acid) (PAA)-Chitosan (CS) as anionic inner-cationic outer layer respectively and conjugated with QT. Subsequently, grafting of arginine-glycine-aspartic acid (cRGD) peptide on the surface of nanocarrier (CPMSN) thwarted the uptake by normal cells, but facilitated their uptake in cancer cells through integrin receptor mediated endocytosis and the dissociation of nanocarriers due to the ability to degrade CS and PAA in acidic pH, which enhance the intracellular release of drugs. Subsequently, the released drugs induce remarkable molecular activation as well as structural changes in tumor cell endoplasmic reticulum, nucleus and mitochondria that can trigger cell death. The valuable CPMSNs may open up new avenues in developing targeted therapeutic strategies to treat cancer through serving as an effective drug delivery podium.

Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells

2016 ◽  
Vol 1860 (10) ◽  
pp. 2065-2075 ◽  
Author(s):  
Abhijit Sarkar ◽  
Shatadal Ghosh ◽  
Sayantani Chowdhury ◽  
Bhawna Pandey ◽  
Parames C. Sil
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles
Sign in / Sign up

Export Citation Format

Share Document