Content uniformity and tablet hardness testing of intact pharmaceutical tablets by near infrared spectroscopy

2006 ◽  
Vol 557 (1-2) ◽  
pp. 353-359 ◽  
Author(s):  
Marcelo Blanco ◽  
Manel Alcalá
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Content Uniformity ◽  
Hardness Testing ◽  
Pharmaceutical Tablets ◽  
Tablet Hardness

scholarly journals Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

2017 ◽  
Vol 6 (2) ◽  
pp. 2006 ◽  
Author(s):  
Hiren J. Patel
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Oral Delivery ◽  
Near Infrared ◽  
Oral Route ◽  
Content Uniformity ◽  
Ongoing Research ◽  
Regulatory Status ◽  
Tablet Hardness ◽  
Non Destructive

The continuous preference of the oral route for the delivery of the drugs has led the ongoing research in the field of oral delivery. With emergence of Near-infrared spectroscopy (NIRS) as a fast and non-destructive analytical method, researchers have used NIRS for non-destructive evaluation of tablets. This review looks at the basics, theoretical aspects of NIRS, qualitative and quantitative treatment of sample spectra for better understanding of NIRS in tablet evaluation. Use of NIRS in tablet evaluation is discussed in detail with focus on evaluation of tablet hardness, content uniformity and dissolution with use of NIRS. In addition to advantages and limitation of use of NIRS, the current regulatory status and exploration of NIRS as a PAT tool is discussed in the later part of the review.

Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool

Talanta ◽  
2015 ◽  
Vol 144 ◽  
pp. 1352-1359 ◽  
Author(s):  
Pierre-François Chavez ◽  
Pierre-Yves Sacré ◽  
Charlotte De Bleye ◽  
Lauranne Netchacovitch ◽  
Jérôme Mantanus ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Pharmaceutical Tablets ◽  
Content Determination ◽  
Technology Tool ◽  
Analytical Technology ◽  
Active Content
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