A cell-penetrating peptide derived from mammalian cell uptake protein of Mycobacterium tuberculosis

2006 ◽  
Vol 353 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Sangwei Lu ◽  
Leah A. Tager ◽  
Sadhana Chitale ◽  
Lee W. Riley
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mammalian Cell ◽  
Cell Uptake ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

scholarly journals In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2245
Author(s):  
Hideo Takakura ◽  
Honoka Sato ◽  
Kohei Nakajima ◽  
Motofumi Suzuki ◽  
Mikako Ogawa
Keyword(s):  
Fluorescent Dyes ◽  
Chemical Properties ◽  
Cyanine Dyes ◽  
Cell Uptake ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell ◽  
Targeting Strategy

In molecular imaging, a targeting strategy with ligands is widely used because specificity can be significantly improved. In fluorescence imaging based on a targeting strategy, the fluorescent dyes conjugated with ligands may affect the targeting efficiency depending on the chemical properties. Herein, we used a cell-penetrating peptide (CPP) as a ligand with a variety of fluorescent cyanine dye. We investigated in vitro and in vivo cell uptake of the dye-CPP conjugates when cyanine dyes with differing charge and hydrophilicity/lipophilicity were used. The results showed that the conjugates with positively charged and lipophilic cyanine dyes accumulated in cancer cells in vitro, but there was almost no accumulation in tumors in vivo. On the other hand, the conjugates with negatively charged and hydrophilic cyanine dyes did not accumulate in cancer cells in vitro, but fluorescence was observed in tumors in vivo. These results show that there are some cases in which the cell uptake of the dye-peptide conjugates may differ significantly between in vitro and in vivo experiments due to the chemical properties of the fluorescent dyes. This suggests that attention should be paid to the chemical properties of fluorescent dyes in fluorescence imaging based on a targeting strategy.

18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells

2012 ◽  
Vol 39 (8) ◽  
pp. 1202-1212 ◽  
Author(s):  
Susan Richter ◽  
Vincent Bouvet ◽  
Melinda Wuest ◽  
Ralf Bergmann ◽  
Joerg Steinbach ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cell Uptake ◽  
Cell Penetrating Peptide ◽  
Human Cancer Cells ◽  
Cell Penetrating

scholarly journals A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Makoto Oba ◽  
Takuma Kato ◽  
Kaori Furukawa ◽  
Masakazu Tanaka
Keyword(s):  
Gene Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Amine Structure ◽  
A Cell

Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide−Morpholino Oligomer Conjugate

2007 ◽  
Vol 18 (4) ◽  
pp. 1325-1331 ◽  
Author(s):  
Adams Amantana ◽  
Hong M. Moulton ◽  
Melissa L. Cate ◽  
Muralimohan T. Reddy ◽  
Tom Whitehead ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide

2011 ◽  
Vol 112 (9) ◽  
pp. 2454-2462
Author(s):  
Seung Won Yang ◽  
Seung-Min Lee ◽  
Eun Young Choi ◽  
Kyung Hye Lee ◽  
Soo Hyuk Kim ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cell Penetrating Peptide ◽  
Matrix Metalloproteinase 1 ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide

Biomaterials ◽  
2014 ◽  
Vol 35 (13) ◽  
pp. 4082-4087 ◽  
Author(s):  
Likun Fei ◽  
Li-Peng Yap ◽  
Peter S. Conti ◽  
Wei-Chiang Shen ◽  
Jennica L. Zaro
Keyword(s):  
Tumor Targeting ◽  
Ph Sensitive ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide

2020 ◽  
Vol 17 ◽  
pp. 250-256
Author(s):  
Shanna J. Smith ◽  
Caroline M. Li ◽  
Robert G. Lingeman ◽  
Robert J. Hickey ◽  
Yilun Liu ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Molecular Targeting ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

scholarly journals A comparison of acyl-moieties for noncovalent functionalization of PLGA and PEG-PLGA nanoparticles with a cell-penetrating peptide

RSC Advances ◽  
2021 ◽  
Vol 11 (57) ◽  
pp. 36116-36124
Author(s):  
Omar Paulino da Silva Filho ◽  
Muhanad Ali ◽  
Rike Nabbefeld ◽  
Daniel Primavessy ◽  
Petra H. Bovee-Geurts ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Plga Nanoparticles ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Noncovalent Functionalization ◽  
Cell Penetrating ◽  
A Cell

Noncovalent functionalization with acylated cell-penetrating peptides achieves an efficient cellular uptake of PLGA and PEG-PLGA nanoparticles.

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