Chemical Ligation and Isotope Labeling to Locate Dynamic Effects

2017 ◽  
pp. 23-41 ◽  
Author(s):  
Alan F. Scott ◽  
Louis Y.P. Luk ◽  
Rudolf K. Allemann
Keyword(s):  
Isotope Labeling ◽  
Dynamic Effects ◽  
Chemical Ligation

scholarly journals Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase

2015 ◽  
Vol 127 (31) ◽  
pp. 9144-9148 ◽  
Author(s):  
Louis Y. P. Luk ◽  
J. Javier Ruiz-Pernía ◽  
Aduragbemi S. Adesina ◽  
E. Joel Loveridge ◽  
Iñaki Tuñón ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Isotope Labeling ◽  
Dynamic Effects ◽  
Chemical Ligation

scholarly journals Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase

2015 ◽  
Vol 54 (31) ◽  
pp. 9016-9020 ◽  
Author(s):  
Louis Y. P. Luk ◽  
J. Javier Ruiz-Pernía ◽  
Aduragbemi S. Adesina ◽  
E. Joel Loveridge ◽  
Iñaki Tuñón ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Isotope Labeling ◽  
Dynamic Effects ◽  
Chemical Ligation

scholarly journals Minimization of dynamic effects in the evolution of dihydrofolate reductase

2016 ◽  
Vol 7 (5) ◽  
pp. 3248-3255 ◽  
Author(s):  
J. Javier Ruiz-Pernía ◽  
Enas Behiry ◽  
Louis Y. P. Luk ◽  
E. Joel Loveridge ◽  
Iñaki Tuñón ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Enzyme Catalysis ◽  
Isotope Labeling ◽  
Conformational Dynamics ◽  
Dynamic Effects ◽  
Powerful Technique ◽  
P Protein

Protein isotope labeling is a powerful technique to probe functionally important motions in enzyme catalysis and can be applied to investigate the conformational dynamics of proteins.

Electron probe x-ray microanalysis and electron microscopy of amino acid absorption and transport by the small intestine: inhibition by chemical poisons and correlation to the elemental composition of the epithelial cells

1986 ◽  
Vol 44 ◽  
pp. 134-135
Author(s):  
A. J. Tousimis
Keyword(s):  
Small Intestine ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Elemental Composition ◽  
Isotope Labeling ◽  
Structural Components ◽  
X Ray ◽  
Human Small Intestine ◽  
Transport Studies

The elemental composition of amino acids is similar to that of the major structural components of the epithelial cells of the small intestine and other tissues. Therefore, their subcellular localization and concentration measurements are not possible by x-ray microanalysis. Radioactive isotope labeling: I131-tyrosine, Se75-methionine and S35-methionine have been successfully employed in numerous absorption and transport studies. The latter two have been utilized both in vitro and vivo, with similar results in the hamster and human small intestine. Non-radioactive Selenomethionine, since its absorption/transport behavior is assumed to be the same as that of Se75- methionine and S75-methionine could serve as a compound tracer for this amino acid.

Effect of networks on product innovation: empirical evidence from Indonesian SMEs

2013 ◽  
Vol 1 (2) ◽  
pp. 140-158 ◽  
Author(s):  
Nurul Indarti ◽  
Theo Postma
Keyword(s):  
Empirical Evidence ◽  
Product Innovation ◽  
Dynamic Effects ◽  
Depth Of Knowledge ◽  
External Knowledge ◽  
Software Firms ◽  
Using Data

Innovative companies generally establish linkages with other actors and access external knowledge in order to benefit from the dynamic effects of interactive processes. Using data from 198 furniture and software firms in Indonesia, this study shows that the quality of interaction (i.e. multiplexity) as indicated by the depth of knowledge absorbed from various external parties and intensity of interaction (i.e., tie intensity) are better predictors of product innovation than the diversity of interaction.

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