Enzymatic Cleavage of Glycosidic Bonds

ENZYMATIC CLEAVAGE AND FORMATION OF GLYCOSIDIC BONDS: FROM GLYCOSIDASES AND LYASES TO TRANSFERASES AND GLYCOSYNTHASES

XXIst International Carbohydrate Symposium 2002 ◽

10.1100/tsw.2002.355 ◽

2002 ◽

Author(s):

Stephen G. Withers

Keyword(s):

Enzymatic Cleavage ◽

Glycosidic Bonds

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Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C–C glycosidic bonds

Applied Microbiology and Biotechnology ◽

10.1007/s00253-019-10333-z ◽

2020 ◽

Vol 104 (5) ◽

pp. 1883-1890 ◽

Cited By ~ 1

Author(s):

Bin Wei ◽

Ya-Kun Wang ◽

Wen-Hui Qiu ◽

Si-Jia Wang ◽

Yue-Hong Wu ◽

...

Keyword(s):

Intestinal Bacteria ◽

Enzymatic Cleavage ◽

Glycosidic Bonds

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Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

10.26434/chemrxiv.7157507 ◽

2018 ◽

Author(s):

Sarah Klass ◽

Matthew J. Smith ◽

Tahoe Fiala ◽

Jessica Lee ◽

Anthony Omole ◽

...

Keyword(s):

Drug Delivery ◽

Fusion Proteins ◽

Organic Molecules ◽

Intrinsically Disordered Protein ◽

Protein Domain ◽

Enzymatic Cleavage ◽

Intrinsically Disordered ◽

Disordered Protein ◽

Self Assembling ◽

Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

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Faculty Opinions recommendation of Self-assembling multidomain peptide hydrogels: designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5196957.5135055 ◽

2010 ◽

Author(s):

Melissa Starovasnik ◽

Christopher Koth

Keyword(s):

Cell Migration ◽

Enzymatic Cleavage ◽

Self Assembling ◽

Peptide Hydrogels

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Natural Macromolecules with Protective and Antitumor Activity

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520618666180425115029 ◽

2018 ◽

Vol 18 (5) ◽

pp. 675-683 ◽

Cited By ~ 2

Author(s):

Cioanca Oana ◽

Trifan Adriana ◽

Cornelia Mircea ◽

Scripcariu Dragos ◽

Hancianu Monica

Keyword(s):

Immune Response ◽

Antitumor Activity ◽

Tumor Cells ◽

Biological Activities ◽

Molecular Size ◽

Plant Lectins ◽

Natural Toxins ◽

Glycosidic Bonds ◽

Novel Drug

This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.

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Glucan isolated from leaves of Althaea officinalis L.

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19832082 ◽

1983 ◽

Vol 48 (7) ◽

pp. 2082-2087 ◽

Cited By ~ 6

Author(s):

Alžbeta Kardošová ◽

Jozef Rosík ◽

Rudolf Toman ◽

Peter Capek

Keyword(s):

Medicinal Plant ◽

Periodate Oxidation ◽

Linear Structure ◽

Water Soluble ◽

Partial Hydrolysis ◽

Methylation Analysis ◽

Glycosidic Bonds ◽

Nmr Data ◽

Althaea Officinalis ◽

C Nmr

A water-soluble low-molecular D-glucan was isolated from leaves of the medicinal plant marsh-mallow (Althaea officinalis L.). The results of methylation analysis, partial hydrolysis, periodate oxidation, and 13C NMR data indicated a virtually linear structure with α-(1→6) glycosidic bonds.

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Polysaccharides from the Flowers of Malva silvestris L., ssp. mauritiana (L.) THELL.: The Structure of D-Glucan

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19922400 ◽

1992 ◽

Vol 57 (11) ◽

pp. 2400-2406 ◽

Cited By ~ 1

Author(s):

Peter Capek

Keyword(s):

Molecular Weight ◽

Ion Exchange ◽

Average Molecular Weight ◽

Linear Structure ◽

Gel Chromatography ◽

Spectroscopic Investigations ◽

Glycosidic Bonds

The neutral polysaccharide α-D-glucan was isolated from the flowers of Malva silvestris L., ssp. mauritiana (L.) THELL. using a combination of ion exchange and gel chromatography. It was homogeneous under the conditions of free electrophoresis of average molecular weight Mn 25260. The chemical and spectroscopic investigations indicated a linear structure of the polysaccharide in which the α-D-glucopyranose units were linked predominantly by 1→6 glycosidic bonds, while some saccharides were the place of branching in position C-3.

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