1997 ◽  
Vol 61 (2) ◽  
pp. 163-170 ◽  
Author(s):  
J.-M. NAM
Keyword(s):  

2001 ◽  
pp. 834-835
Author(s):  
M. Tracey
Keyword(s):  

2004 ◽  
Vol 13 (6) ◽  
pp. 1409-1421 ◽  
Author(s):  
Peter Galbusera ◽  
Mwangi Githiru ◽  
Luc Lens ◽  
Erik Matthysen

2016 ◽  
Author(s):  
Monica Nordberg ◽  
Douglas M. Templeton ◽  
Ole Andersen ◽  
John H. Duffus

1929 ◽  
Vol 36 (5) ◽  
pp. 248
Author(s):  
Tobias Dantzig ◽  
William Kemp
Keyword(s):  

2012 ◽  
pp. 154-161
Author(s):  
Francisco Javier León ◽  
Fernando Rondón González ◽  
Clara Inés Vargas Castellanos ◽  
Myriam Oróstegui ◽  
Leonelo Bautista ◽  
...  

Introduction: In spite nearly 40% of the variability in blood pressure can be explained by genetic factors, the identifi­cation of genes associated to essential high blood pressure is difficult in populations where individuals have different genetic precedents; in these circumstances it is necessary to determinate whether the population is sub-structured because this can bias studies associated with this disease. Objectives: To determine the genetic structure of the population in Bucaramanga from genetic polymorphisms asso­ciated with the regulation of blood pressure: 448G>T, 679C>T y 1711C>T from the gene kinase 4 of the dopaminergic receptor linked to the protein G and Glu298Asp, -786T>C and the VNTR of the intron 4 of the gene of endothelial nitric oxide. Methodology: A sample of 552 unrelated individuals was studied through analysis of Restriction fragment length polymorphism. The allelic, haplotypic and genotypic frequencies were calculated, the Hardy-Weinberg equilibrium was determined and a molecular analysis of variance was performed to determine the genetic structure. Results: 38 Haplotypes were identified, with GCCTG4b as the most frequent (21.2%). The most diverse polymorphism was 448G>T with a frequency of 49.9% for heterozygous. The six polymorphisms were found in genetic equilibrium and genetic structure of populations was not evidenced (FST = 0,0038). Conclusion: The population studied does not present a genetic sub-structure and the polymorphisms analyzed were found in genetic equilibrium, this indicates that the population mixes randomly and there are no sub-groups capable of affecting the results of the association studies


Genetics ◽  
1929 ◽  
Vol 14 (1) ◽  
pp. 85-127
Author(s):  
W B Kemp
Keyword(s):  

2017 ◽  
Vol 13 (01) ◽  
pp. 01-03
Author(s):  
Simone Camosso
Keyword(s):  

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