Affected-Sib-Pair Method (ASP)

2012 ◽  
Keyword(s):  
Affected Sib Pair ◽  
Pair Method

THE AFFECTED SIB METHOD. I. STATISTICAL FEATURES OF THE AFFECTED SIB-PAIR METHOD

Genetics ◽  
1985 ◽  
Vol 110 (3) ◽  
pp. 525-538
Author(s):  
Uzi Motro ◽  
Glenys Thomson
Keyword(s):  
General Population ◽  
Cluster Sampling ◽  
Sampling Techniques ◽  
Statistical Features ◽  
Affected Sib Pair ◽  
Pair Method ◽  
Sib Pair Analysis ◽  
Single Allele ◽  
Hla Haplotypes ◽  
Pair Analysis

ABSTRACT The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (θ = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis.

Impact of parental relationships in maximum lod score affected sib-pair method

2002 ◽  
Vol 23 (4) ◽  
pp. 413-425 ◽  
Author(s):  
Anne-Louise Leutenegger ◽  
Emmanuelle Génin ◽  
Elizabeth A. Thompson ◽  
Françoise Clerget-Darpoux
Keyword(s):  
Lod Score ◽  
Parental Relationships ◽  
Affected Sib Pair ◽  
Pair Method

Power of the affected-sib-pair method for heterogeneous disorders

1988 ◽  
Vol 5 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Lynn R. Goldin ◽  
Elliot S. Gershon ◽  
I. B. Borecki
Keyword(s):  
Affected Sib Pair ◽  
Pair Method

Commentary: The affected sib-pair method in the context of an epidemiologic study design

1991 ◽  
Vol 8 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Muin J. Khoury ◽  
W. Dana Flanders ◽  
Rebecca B. Lipton ◽  
Janice S. Dorman ◽  
G. P. Vogler
Keyword(s):  
Study Design ◽  
Epidemiologic Study ◽  
Affected Sib Pair ◽  
Pair Method
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