Impact of parental relationships in maximum lod score affected sib-pair method

2002 ◽  
Vol 23 (4) ◽  
pp. 413-425 ◽  
Author(s):  
Anne-Louise Leutenegger ◽  
Emmanuelle Génin ◽  
Elizabeth A. Thompson ◽  
Françoise Clerget-Darpoux
Keyword(s):  
Lod Score ◽  
Parental Relationships ◽  
Affected Sib Pair ◽  
Pair Method

THE AFFECTED SIB METHOD. I. STATISTICAL FEATURES OF THE AFFECTED SIB-PAIR METHOD

Genetics ◽  
1985 ◽  
Vol 110 (3) ◽  
pp. 525-538
Author(s):  
Uzi Motro ◽  
Glenys Thomson
Keyword(s):  
General Population ◽  
Cluster Sampling ◽  
Sampling Techniques ◽  
Statistical Features ◽  
Affected Sib Pair ◽  
Pair Method ◽  
Sib Pair Analysis ◽  
Single Allele ◽  
Hla Haplotypes ◽  
Pair Analysis

ABSTRACT The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (θ = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis.

A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11

1993 ◽  
Vol 23 (1) ◽  
pp. 27-44 ◽  
Author(s):  
M. Gill ◽  
P. McGuffin ◽  
E. Parfitt ◽  
R. Mant ◽  
P. Asherson ◽  
...  
Keyword(s):  
Genetic Parameters ◽  
Single Gene ◽  
Major Effect ◽  
Linkage Study ◽  
Chromosome 11 ◽  
Lod Score ◽  
Psychotic Illness ◽  
Pair Method ◽  
Score Method ◽  
Balanced Translocations

SynopsisWe report the results of a collaborative linkage study using 12 polymorphic markers (9 loci) from the long arm of chromosome 11, and 24 families multiply affected with schizophrenia and other closely related disorders. This region is of interest because several families have been reported in which balanced translocations involving 11q apparently co-segregate with psychotic illness. In addition, the dopamine D2 receptor, porphobilinogen deaminase, and tyrosinase genes map within the region studied and may be aetiologically involved in schizophrenia. We have primarily analysed genotypic data by the LOD score method using a range of single gene models. In order to minimize error due to mis-specification of genetic parameters we have analysed data from markers at candidate gene loci by the non-parametric extended sib-pair method in addition to the LOD score method. Our results suggest that most of the region can be excluded from containing a gene of major effect in the aetiology of this disease.

Power of the affected-sib-pair method for heterogeneous disorders

1988 ◽  
Vol 5 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Lynn R. Goldin ◽  
Elliot S. Gershon ◽  
I. B. Borecki
Keyword(s):  
Affected Sib Pair ◽  
Pair Method

Commentary: The affected sib-pair method in the context of an epidemiologic study design

1991 ◽  
Vol 8 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Muin J. Khoury ◽  
W. Dana Flanders ◽  
Rebecca B. Lipton ◽  
Janice S. Dorman ◽  
G. P. Vogler
Keyword(s):  
Study Design ◽  
Epidemiologic Study ◽  
Affected Sib Pair ◽  
Pair Method
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