Crucial Role of c-Jun NH2-Terminal Kinase 1 (JNK1) in Cold-Restraint Stress-Induced Gastric Lesions in Mice

2006 ◽  
Vol 52 (7) ◽  
pp. 1698-1705 ◽  
Author(s):  
K. Kasugai ◽  
S. J. Watson ◽  
R. A. Flavell ◽  
R. J. Davis ◽  
A. Todisco
Keyword(s):  
Crucial Role ◽  
Restraint Stress ◽  
Gastric Lesions ◽  
Cold Restraint Stress ◽  
Cold Restraint

Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold restraint stress-induced gastric lesions in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A307
Author(s):  
Kunio Kasugai ◽  
Stanley J. Watson ◽  
Richard A. Flavell ◽  
Roger J. Davis ◽  
Andrea Todisco
Keyword(s):  
Crucial Role ◽  
Restraint Stress ◽  
Gastric Lesions ◽  
Cold Restraint Stress ◽  
Cold Restraint

Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold restraint stress-induced gastric lesions in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A307-A307
Author(s):  
K KASUGAI ◽  
S WATSON ◽  
R FLAVELL ◽  
R DAVIS ◽  
A TODISCO
Keyword(s):  
Crucial Role ◽  
Restraint Stress ◽  
Gastric Lesions ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Hypericum Perforatum L. Hypericaceae/Guttiferae Sunflower, Olive and Palm Oil Еxtracts Attenuate Cold Restraint Stress – Induced Gastric Lesions

Molecules ◽  
2010 ◽  
Vol 15 (10) ◽  
pp. 6688-6698 ◽  
Author(s):  
Ivana Arsić ◽  
Ana Žugić ◽  
Dušanka Runjajić Antić ◽  
Gordana Zdunić ◽  
Dragana Dekanski ◽  
...  
Keyword(s):  
Palm Oil ◽  
Restraint Stress ◽  
Hypericum Perforatum ◽  
Gastric Lesions ◽  
Hypericum Perforatum L ◽  
Cold Restraint Stress ◽  
Cold Restraint

Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: Role of NO, HO-1, and COX-1,2

Nitric Oxide ◽  
2012 ◽  
Vol 27 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Mohamed A. Morsy ◽  
Gehan H. Heeba ◽  
Soha A. Abdelwahab ◽  
Remon R. Rofaeil
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Protective Effects ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Macrorhage Phagocytic Activity at Acute Cold-Restraint Stress Exposed Rats: Possible Role of Nitric Oxide

2005 ◽  
Vol 19 (3) ◽  
pp. 133-138 ◽  
Author(s):  
C. Turner ◽  
H.M. Bilgin ◽  
B.D. Obay ◽  
H. Diken ◽  
E. Tasdemir ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Phagocytic Activity ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

Cold restraint stress-induced gastric mucosal dysfunction role of nitric oxide

1996 ◽  
Vol 41 (5) ◽  
pp. 956-963 ◽  
Author(s):  
Tamer Coskun ◽  
Berrak C. YeĞen ◽  
Inci Alican ◽  
Önder Peker ◽  
Hizir Kurtel
Keyword(s):  
Nitric Oxide ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium

2010 ◽  
Vol 299 (3) ◽  
pp. G572-G584 ◽  
Author(s):  
G. Samak ◽  
T. Suzuki ◽  
A. Bhargava ◽  
R. K. Rao
Keyword(s):  
Osmotic Stress ◽  
Actin Cytoskeleton ◽  
Restraint Stress ◽  
Paracellular Permeability ◽  
Cell Monolayers ◽  
Cold Restraint Stress ◽  
Jnk Activation ◽  
Mouse Ileum ◽  
Cold Restraint

Gastrointestinal epithelium faces osmotic stress, both at physiological and pathophysiological conditions. JNK activation is an immediate cellular response to osmotic stress. We investigated the effect of osmotic stress on intestinal epithelial barrier function and delineated the role of JNK2 in osmotic stress-induced tight junction (TJ) regulation in Caco-2 cell monolayers and ileum of Jnk −/− and Jnk2 −/− mice. The role of JNK activation in osmotic stress-induced TJ disruption was evaluated using JNK-specific inhibitor and antisense oligonucleotides. Furthermore, the effect of cold restraint stress in vivo on TJ integrity was determined in rats. Osmotic stress disrupted TJs and barrier function in Caco-2 cell monolayers without affecting cell viability. Osmotic stress activated JNK1 and JNK2 and the inhibition of JNK by SP600125 attenuated osmotic stress-induced TJ disruption. TJ disruption and barrier dysfunction by osmotic stress was associated with JNK-dependent remodeling of actin cytoskeleton. Knockdown of JNK2 accelerated TJ assembly and attenuated osmotic stress-induced TJ disruption in Caco-2 cell monolayers. In mouse ileum in vitro, osmotic stress increased paracellular permeability, which was attenuated by SP600125. Osmotic stress disrupted actin cytoskeleton and TJs and increased paracellular permeability in the ileum of wild-type and JNK1 −/− mice, but not in JNK2 −/− mouse ileum. Cold restraint stress activated JNK in rat ileum and caused JNK-dependent remodeling of actin cytoskeleton and redistribution of occludin and zona occluden-1 from the intercellular junctions. These results reveal the role of JNK2 in the mechanism of osmotic stress-induced TJ disruption in the intestinal epithelium.

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