Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: Role of NO, HO-1, and COX-1,2

Nitric Oxide ◽  
2012 ◽  
Vol 27 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Mohamed A. Morsy ◽  
Gehan H. Heeba ◽  
Soha A. Abdelwahab ◽  
Remon R. Rofaeil
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Protective Effects ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats

2020 ◽  
Vol 53 (3) ◽  
pp. 301-312
Author(s):  
Samaa Samir Kamar ◽  
Noha Samir Abdel Latif ◽  
Mohamed Fathi Mohamed Elrefai ◽  
Shaimaa Nasr Amin
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals EFFECT OF SYNTHETIC ACYCLIC POLYISOPRENOIDS ON THE COLD-RESTRAINT STRESS INDUCED GASTRIC ULCER IN RATS

1983 ◽  
Vol 33 (3) ◽  
pp. 549-556
Author(s):  
Manabu MURAKAMI ◽  
Kiyoshi OKETANI ◽  
Hideaki FUJISAKI ◽  
Tsuneo WAKABAYASHI ◽  
Yuichi INAI ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Macrorhage Phagocytic Activity at Acute Cold-Restraint Stress Exposed Rats: Possible Role of Nitric Oxide

2005 ◽  
Vol 19 (3) ◽  
pp. 133-138 ◽  
Author(s):  
C. Turner ◽  
H.M. Bilgin ◽  
B.D. Obay ◽  
H. Diken ◽  
E. Tasdemir ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Phagocytic Activity ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

Cold restraint stress-induced gastric mucosal dysfunction role of nitric oxide

1996 ◽  
Vol 41 (5) ◽  
pp. 956-963 ◽  
Author(s):  
Tamer Coskun ◽  
Berrak C. YeĞen ◽  
Inci Alican ◽  
Önder Peker ◽  
Hizir Kurtel
Keyword(s):  
Nitric Oxide ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold restraint stress-induced gastric lesions in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A307
Author(s):  
Kunio Kasugai ◽  
Stanley J. Watson ◽  
Richard A. Flavell ◽  
Roger J. Davis ◽  
Andrea Todisco
Keyword(s):  
Crucial Role ◽  
Restraint Stress ◽  
Gastric Lesions ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium

2010 ◽  
Vol 299 (3) ◽  
pp. G572-G584 ◽  
Author(s):  
G. Samak ◽  
T. Suzuki ◽  
A. Bhargava ◽  
R. K. Rao
Keyword(s):  
Osmotic Stress ◽  
Actin Cytoskeleton ◽  
Restraint Stress ◽  
Paracellular Permeability ◽  
Cell Monolayers ◽  
Cold Restraint Stress ◽  
Jnk Activation ◽  
Mouse Ileum ◽  
Cold Restraint

Gastrointestinal epithelium faces osmotic stress, both at physiological and pathophysiological conditions. JNK activation is an immediate cellular response to osmotic stress. We investigated the effect of osmotic stress on intestinal epithelial barrier function and delineated the role of JNK2 in osmotic stress-induced tight junction (TJ) regulation in Caco-2 cell monolayers and ileum of Jnk −/− and Jnk2 −/− mice. The role of JNK activation in osmotic stress-induced TJ disruption was evaluated using JNK-specific inhibitor and antisense oligonucleotides. Furthermore, the effect of cold restraint stress in vivo on TJ integrity was determined in rats. Osmotic stress disrupted TJs and barrier function in Caco-2 cell monolayers without affecting cell viability. Osmotic stress activated JNK1 and JNK2 and the inhibition of JNK by SP600125 attenuated osmotic stress-induced TJ disruption. TJ disruption and barrier dysfunction by osmotic stress was associated with JNK-dependent remodeling of actin cytoskeleton. Knockdown of JNK2 accelerated TJ assembly and attenuated osmotic stress-induced TJ disruption in Caco-2 cell monolayers. In mouse ileum in vitro, osmotic stress increased paracellular permeability, which was attenuated by SP600125. Osmotic stress disrupted actin cytoskeleton and TJs and increased paracellular permeability in the ileum of wild-type and JNK1 −/− mice, but not in JNK2 −/− mouse ileum. Cold restraint stress activated JNK in rat ileum and caused JNK-dependent remodeling of actin cytoskeleton and redistribution of occludin and zona occluden-1 from the intercellular junctions. These results reveal the role of JNK2 in the mechanism of osmotic stress-induced TJ disruption in the intestinal epithelium.

scholarly journals Evaluation of Antiulcerogenic Activity of Clerodendron Infortunatum Extract on Albino Rat Gastric Ulceration

2019 ◽  
Vol 9 (4-A) ◽  
pp. 57-62
Author(s):  
Arun Kumar ◽  
Rahul Shukla ◽  
Anurag Chaudhary
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Restraint Stress ◽  
Ethanolic Extract ◽  
North India ◽  
Gastric Ulcers ◽  
Albino Rat ◽  
Pylorus Ligation ◽  
Cold Restraint Stress ◽  
Cold Restraint

Clerodendron infortunatum Linn. (Verbenaceae) is an important and widely used medicinal plant, reported to contain active bitter substance like clerodin, has been widely used as tonic and anthelmintic agent in the country sides of North India. Though, variously used in Ayurveda, Unani system of medicine and Homeopathy in case of ailments like diarrhoea, skin disorders, venereal and scrofulous complaints, wounds, post-natal complications, as vermifuge, laxative and cholagogue, for the removal of ascarids in anus, as external applications on tumours, etc., Background: The present study reports the antiulcer properties of 50% ethanolic extract of Clerodendron infortunatum Linn. (Verbenaceae) leaves have assessed in different acute and chronic gastric ulcer models in rats. Methods: EECI (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from ethanol (EtOH), Cold-restraint stress (CRS), Pylorus-ligation (PL) and 10 days for prevention of acetic acid induced ulcers. Results: The EECI showed significant gastric ulcer protective effect in doses of 400 mg/kg, when given twice daily for 5 days against gastric ulcers induced by ethanol (EtOH), cold restraint stress (CRS) and pyloric ligation (PL). EECI showed dose dependent decrease in ulcer index (UI) against ulcers induced by: (i) Ethanol (control UI: 29.52±2.4 mm2/rat, EECI decrease 21.12±2.3 – 5.3±1.0 (ii) Cold restraint stress (CRS) (control UI: 32.13±2.1, EECI decrease 24.02±2.2 – 4.7±1.1 (iii) pylorus ligation (control UI: 29.25±2.4 mm2/rat, EECI decrease 22.32±2.7 – 5.3±1.0, EECI 400 mg/kg significantly healed ulcers induced by 50% acetic acid after 5 (control UI: 32.30 ± 2.9, EECI decrease 26.27±1.9 – 8.56±0.98 and after 10 days treatment (control UI: 29.02 ± 2.6, healing 21.28±2.1 – 5.78±1.2. EECI prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, and increase in catalase activity. Conclusions: Our results show that Clerodendron infortunatum Linn. (Verbenaceae)  possess significant gastro-protective activity which might be due to gastric defence factors and clerodin might be the main constituents responsible for this activity.

Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold restraint stress-induced gastric lesions in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A307-A307
Author(s):  
K KASUGAI ◽  
S WATSON ◽  
R FLAVELL ◽  
R DAVIS ◽  
A TODISCO
Keyword(s):  
Crucial Role ◽  
Restraint Stress ◽  
Gastric Lesions ◽  
Cold Restraint Stress ◽  
Cold Restraint
Sign in / Sign up

Export Citation Format

Share Document