scholarly journals Molecular variation within the dopamine receptor DRD2 gene in migraine

2000 ◽  
Vol 1 (S2) ◽  
pp. S147-S151 ◽  
Author(s):  
Stephen J. Peroutka
Keyword(s):  
Dopamine Receptor ◽  
Molecular Variation ◽  
Drd2 Gene

scholarly journals Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction

2020 ◽  
Vol 17 (21) ◽  
pp. 8174
Author(s):  
Yu Jiang ◽  
Baoying Liu ◽  
Chuancheng Wu ◽  
Xiaoyan Gao ◽  
Yaoqin Lu ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Job Stress ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Significant Negative Correlation ◽  
Drd2 Gene ◽  
Sleep Dysfunction ◽  
Dopamine Receptor D2 ◽  
Effort Reward Imbalance ◽  
Reward Imbalance

Recent studies have shown that incessant job stress could eventually result in sleep dysfunction (SD), and most importantly, the essential role dopamine receptor D2 (DRD2) gene polymorphisms play in the psychopathological mechanism of SD. The Effort-Reward Imbalance scale and the Pittsburgh Sleep Quality Index were both used to access SD and job stress (JS). A significant negative correlation was observed between the sDA levels and SD subscale scores (sleep efficiency, daytime dysfunction). The findings revealed that high levels of JS were linked to a higher SD score (OR = 2.13, 95% CI: 1.46–3.12). Likewise, the homozygous A1A1 genotype of DRD2 rs1800497 was more likely to be associated with SD (OR = 2.90, 95% CI: 1.75–4.82). Compared to participants with low JS and heterozygous A1A2/A2A2 genotype, those with both high JS and homozygous A1A1 genotype had a higher SD score (OR = 5.40, 95% CI: 2.89–10.11). The A1 allele of the DRD2 rs1800497 polymorphism also enhances the likelihood of SD when undergoing JS. Besides, subjects with low JS and the homozygous A1A1 genotype also showed an increased possibility for sleep dysfunction (OR = 2.05, 95% CI: 1.03–4.11). Our results suggest that the DA system may interrelate with JS to affect sleep.

D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

2002 ◽  
Vol 17 (1) ◽  
pp. 17-23 ◽  
Author(s):  
J.P. Connor ◽  
R.McD. Young ◽  
B.R. Lawford ◽  
T.L. Ritchie ◽  
E.P. Noble
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Problem Drinking ◽  
Drinking Behavior ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Allele Status ◽  
Alcohol Detoxification ◽  
Dependence Scale ◽  
Alcohol Dependent

SummaryThe A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics

2009 ◽  
Vol 166 (2-3) ◽  
pp. 91-101 ◽  
Author(s):  
Tim Antolin ◽  
Steven M. Berman ◽  
Bradley T. Conner ◽  
Tulin Z. Ozkaragoz ◽  
Courtney L. Sheen ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Children Of Alcoholics ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene

scholarly journals Cytogenetics And Dopamine Receptor (Drd2) Gene Polymorphism In Schizophrenia Patients

2015 ◽  
Vol 18 (7) ◽  
pp. A344
Author(s):  
I Mahalaxmi ◽  
K Sasikala ◽  
M Arun ◽  
V Balachandar
Keyword(s):  
Gene Polymorphism ◽  
Dopamine Receptor ◽  
Drd2 Gene

scholarly journals Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 135
Author(s):  
Jing Zhao ◽  
Siyuan Gao ◽  
Yanli Guo ◽  
Qinglei Xu ◽  
Mingzheng Liu ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Aggressive Behavior ◽  
Dopamine Receptor ◽  
Negative Effects ◽  
Drd2 Gene ◽  
Single Nucleotide ◽  
Dopamine Receptor D2 ◽  
Interferon Regulatory Factor 1 ◽  
Functional Single Nucleotide Polymorphism ◽  
Dopamine Signal

Aggressive behavior has negative effects on animal welfare and growth performance in pigs. The dopamine receptor D2 (DRD2) has a critical neuromodulator role in the dopamine signal pathway within the brain to control behavior. A functional single-nucleotide polymorphism (SNP), rs1110730503, in the promoter region of the porcine DRD2 gene was identified, which affects aggressive behavior in pigs. A chromatin immunoprecipitation (ChIP) assay was used to identify the interactions between interferon regulatory factor 1 (IRF1) and IRF2 with the DRD2 gene. The overexpression or knockdown of these two transcription factors in porcine kidney-15 (PK15) and porcine neuronal cells (PNCs) indicate that the binding of IRF1 to DRD2 promotes the transcription of the DRD2 gene, but the binding of IRF2 to the DRD2 gene inhibits its transcription. Furthermore, IRF1 and IRF2 are functionally antagonistic to each other. The downregulation of DRD2 or upregulation of IRF2 increased the apoptosis rate of porcine neuroglial cells. Taken together, we found that transcriptional factors IRF1 and IRF2 have vital roles in regulating the transcription of the DRD2 gene, and rs1110730503 (−915A/T) is a functional SNP that influences IRF2 binding to the promoter of the DRD2 gene. These findings will provide further insight towards controlling aggressive behavior in pigs.

Frequency of the A1/A2 alleles of the D2 dopamine receptor (DRD2) gene in a British, Caucasian control group screened to exclude alcoholism and heavy drinking

1997 ◽  
Vol 2 (2) ◽  
pp. 207-213 ◽  
Author(s):  
ADRIAN TURNER ◽  
JACOB LAWRENCE ◽  
ANDREW CHIH-HUI CHEN ◽  
CHRISTOPHER COOK ◽  
HUGH GURLING
Keyword(s):  
Dopamine Receptor ◽  
Heavy Drinking ◽  
Control Group ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene

Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review

2000 ◽  
Vol 15 (2) ◽  
pp. 79-89 ◽  
Author(s):  
E.P. Noble
Keyword(s):  
Dopamine Receptor ◽  
Dopaminergic System ◽  
Substance Abusers ◽  
Association Studies ◽  
Receptor Gene ◽  
Drd2 Gene ◽  
Reward Process ◽  
A Minor ◽  
The Brain ◽  
D2 Dopamine Receptor Gene

SummarySince 1990, association studies have amassed strong evidence implicating the D2 dopamine receptor (DRD2) gene in alcoholism. Specifically, the Taql A minor (A1) allele of the DRD2 gene has been associated with alcoholism. The DRD2 gene has also been found to be involved in other substance use disorders including cocaine, nicotine and opioid dependence, and obesity. Beyond association studies, pharmacologic studies have shown reduced brain D2 dopamine receptor numbers in A1+ allele carriers (A1A1 and A1A2 genotypes) compared to A1– allele carriers (A2A2 genotype). Through a number of other approaches, different phenotypes have also been identified in subjects with the A1+ and A1– alleles. These include metabolic, neurophysiological, neuropsychological, personality, stress and treatment studies. It is hypothesized that in an effort to compensate for deficiencies in the dopaminergic system, substance abusers may seek to stimulate the mesocorticolimbic circuits of the brain, long thought to be important in behavioral reward and reinforcement. In effect, one form of the DRD2 gene, the A1 allele, renders the dopaminergic system inefficient and rewards substance abuse that increases brain dopamine levels.

scholarly journals Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia

2009 ◽  
Vol 67 (2a) ◽  
pp. 191-194 ◽  
Author(s):  
Quirino Cordeiro ◽  
Jacqueline Siqueira-Roberto ◽  
Stevin Zung ◽  
Homero Vallada
Keyword(s):  
Risk Factor ◽  
Dopamine Receptor ◽  
First Generation ◽  
Antipsychotic Drugs ◽  
Dopaminergic System ◽  
Epidemiological Studies ◽  
Receptor Type ◽  
Drd2 Gene ◽  
Deletion Polymorphism

Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between the -141 Ins/Del (rs1799732) polymorphism of the dopamine receptor type 2 (DRD2) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 229 patients and 733 controls. There were statistical differences in the allelic (χ2=9.78; p=0.001) and genotypic genotypic (χ2=12.74; p=0.001) distributions between patients and controls. Thus the -141C Ins/Del polymorphism of the DRD2 gene (allele Ins) was associated to the SCZ phenotype in the investigated sample.

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