D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

2007 ◽  
Vol 12 (2) ◽  
pp. 91-96 ◽  
Author(s):  
E. Nisoli ◽  
A. Brunani ◽  
E. Borgomainerio ◽  
C. Tonello ◽  
L. Dioni ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Psychological Traits

D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

2002 ◽  
Vol 17 (1) ◽  
pp. 17-23 ◽  
Author(s):  
J.P. Connor ◽  
R.McD. Young ◽  
B.R. Lawford ◽  
T.L. Ritchie ◽  
E.P. Noble
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Problem Drinking ◽  
Drinking Behavior ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Allele Status ◽  
Alcohol Detoxification ◽  
Dependence Scale ◽  
Alcohol Dependent

SummaryThe A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics

2009 ◽  
Vol 166 (2-3) ◽  
pp. 91-101 ◽  
Author(s):  
Tim Antolin ◽  
Steven M. Berman ◽  
Bradley T. Conner ◽  
Tulin Z. Ozkaragoz ◽  
Courtney L. Sheen ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Children Of Alcoholics ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene

Frequency of the A1/A2 alleles of the D2 dopamine receptor (DRD2) gene in a British, Caucasian control group screened to exclude alcoholism and heavy drinking

1997 ◽  
Vol 2 (2) ◽  
pp. 207-213 ◽  
Author(s):  
ADRIAN TURNER ◽  
JACOB LAWRENCE ◽  
ANDREW CHIH-HUI CHEN ◽  
CHRISTOPHER COOK ◽  
HUGH GURLING
Keyword(s):  
Dopamine Receptor ◽  
Heavy Drinking ◽  
Control Group ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene

The DRD2 gene and the risk for alcohol dependence in bipolar patients

2000 ◽  
Vol 15 (2) ◽  
pp. 103-108 ◽  
Author(s):  
P. Gorwood ◽  
F. Bellivier ◽  
J. Adès ◽  
M. Leboyer
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Receptor Gene ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Gene Encoding ◽  
Co Morbidity ◽  
Bipolar Patients

SummaryThe high co-morbidity between bipolar disorder and alcohol dependence may have different explanations, one of them being the existence of common genetic factors for the two disorders. Several candidate genes may be involved but the genes acting in the dopaminergic pathway may be more specifically involved. We have thus tested the role of the gene encoding the D2 dopamine receptor (TaqI A1 allele) in the potentially shared vulnerability to alcohol dependence and bipolar disorder.One hundred and twenty-two French (for at least two generations) patients were recruited on the basis of hospital or outpatient files and were interviewed with the DIGS. The A1 allele frequencies were compared between four groups, namely, with bipolar patients and co-morbid alcohol dependence (N = 21), with bipolar patients without alcohol morbidity (N = 31), with alcohol dependence without mood disorder (N = 35) and unaffected controls (N = 35).The Hardy Weinberg equilibrium for the DRD2 Taq1 A1 genotypes was respected for the sample as a whole, and for each subsample. We observed that 42.9% of control subjects have at least one A1 allele, a frequency which is not significantly different from the one observed in the affected sample as a whole (39.1%), neither from patients with alcohol dependence (37.1%), patients with bipolar disorder (48.4%) nor patients with alcohol dependence and bipolar disorder (28.6%). The regression analysis based on the three variables (bipolar disorder, alcohol dependence and interaction between these two disorders) does not explain the presence of the A1 allele of the DRD2 gene.We thus found no evidence for a significant role of the A1 allele of the D2 dopamine receptor gene in the specific association between bipolar disorder and alcohol dependence in our sample.

Role of trace amine associated receptor 1 (TAAR1) in D2 dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine

Role of Trace Amine Associated Receptor 1 (TAAR1) in D2 Dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine
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