Skeletal effects of low-dose cyclosporin A therapy in children with nephrotic syndrome

2000 ◽  
Vol 4 (4) ◽  
pp. 313-317
Author(s):  
K. Kano ◽  
K. Kyo ◽  
K. Nishikura ◽  
M. Hoshi ◽  
S. Ito ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Skeletal Effects

Long-term low-dose cyclosporin A in steroid dependent nephrotic syndrome of childhood

1992 ◽  
Vol 151 (10) ◽  
pp. 775-778 ◽  
Author(s):  
T. J. Neuhaus ◽  
H. R. Burger ◽  
M. Klingler ◽  
A. Fanconi ◽  
E. P. Leumann
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Linear Growth of Low-Dose Cyclosporin A Therapy in Children with Steroid-Dependent Nephrotic Syndrome

Nephron ◽  
2001 ◽  
Vol 87 (3) ◽  
pp. 293-294 ◽  
Author(s):  
Kenichi Kano ◽  
Kiyoshi Nishikura ◽  
Megumi Hoshi ◽  
Yumi Yamada ◽  
Osamu Arisaka
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Linear Growth ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

C1-C2 point monitoring of low-dose cyclosporin A given as a single daily dose in children with steroid-dependent relapsing nephrotic syndrome

2005 ◽  
Vol 64 (10) ◽  
pp. 258-263 ◽  
Author(s):  
T. Nakahata ◽  
H. Tanaka ◽  
K. Tsugawa ◽  
M. Kudo ◽  
K. Suzuki ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Single Daily Dose ◽  
Steroid Dependent ◽  
Daily Dose

Myoclonus Due to Chlorambucil in Two Adults with Lymphoma

1997 ◽  
Vol 31 (2) ◽  
pp. 171-174 ◽  
Author(s):  
Andrew Rj Wyllie ◽  
Charles D Bayliff ◽  
Michael J Kovacs
Keyword(s):  
Nephrotic Syndrome ◽  
Science Citation Index ◽  
Low Dose ◽  
Citation Index ◽  
Science Citation ◽  
Data Sources ◽  
High Dose ◽  
Drug Induced ◽  
Neurologic Status ◽  
Subsequent Decrease

Objective To report myoclonus due to chlorambucil therapy in two adults with lymphoma, and to review the literature of chlorambucil neurotoxicity in adults. Case Summaries Case 1: An 81-year-old man with lymphoma being treated with chlorambucil developed jerking movements and stiffness that persisted for 3 days and intensified at night. The dosage of chlorambucil was decreased with a subsequent decrease in symptomatology. Resolution of the myoclonus occurred with discontinuation of the chlorambucil. Rechallenge evoked a return of tremors the next day that later became constant and again resolved on discontinuation of chlorambucil. Case 2: A 75-year-old woman with lymphoma being treated with chlorambucil developed jerking movements in her limbs, particularly in her arms and right hip. The symptoms were so severe they prevented the patient from leaving her house. All symptoms resolved within 2–3 days after the cycle was completed and did not return. She was diagnosed as having had chlorambucil-induced myoclonus. Data Sources Searches were performed on MEDLINE, CancerLit, and Science Citation Index Review to identify reports and articles discussing chlorambucil-induced neurotoxicity, particularly myoclonus. Discussion Chlorambucil-induced myoclonus has been described in overdose situations and in the treatment of nephrotic syndrome in children. Three cases of reversible myoclonic activity associated with high-dose chlorambucil in adults have also been described. In each case, the myoclonus resolved following discontinuation of the drug. Only one other conclusive case of low-dose chlorambucil-induced myoclonus in an adult has been described. The two cases presented here are unique in that the myoclonus occurred in adults receiving low-dose chlorambucil who had no myoclonus before or after treatment with the drug. Conclusions From the cases reviewed, it appears that chlorambucil may induce myoclonus in adults receiving therapeutic dosages of chlorambucil. The neurologic status of patients receiving chlorambucil should be followed closely during treatment. If myoclonus develops, drug-induced myoclonus should be considered, as well as discontinuation of the drug.

scholarly journals Low-dose ofatumumab for rituximab-resistant nephrotic syndrome

2015 ◽  
pp. bcr2015210208 ◽  
Author(s):  
Alice Bonanni ◽  
Roberta Rossi ◽  
Corrado Murtas ◽  
Gian Marco Ghiggeri
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose

scholarly journals Recurrence of severe steroid dependency in cyclosporin A-treated childhood idiopathic nephrotic syndrome

2004 ◽  
Vol 19 (5) ◽  
pp. 1136-1141 ◽  
Author(s):  
M. J. Kemper ◽  
E. Kuwertz-Broeking ◽  
M. Bulla ◽  
D. E. Mueller-Wiefel ◽  
T. J. Neuhaus
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Dependency

scholarly journals Mycophenolate Mofetil versus Cyclosporin A in Children with Frequently Relapsing Nephrotic Syndrome

2013 ◽  
Vol 24 (10) ◽  
pp. 1689-1697 ◽  
Author(s):  
Jutta Gellermann ◽  
Lutz Weber ◽  
Lars Pape ◽  
Burkhard Tönshoff ◽  
Peter Hoyer ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Mofetil ◽  
Cyclosporin A ◽  
Frequently Relapsing Nephrotic Syndrome
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