Non-steroidal Anti-inflammatory Drugs with Adverse Psychiatric Reactions: Five Case Reports

1999 ◽  
Vol 18 (4) ◽  
pp. 339-345 ◽  
Author(s):  
Hann-Kuang Jiang ◽  
Deh-Ming Chang
Keyword(s):  
Case Reports ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Bilateral Sesamoiditis as First Manifestation of Gout

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Daniel de Oliveira Beraldo ◽  
Sasha Duarte ◽  
Gustavo Pacheco ◽  
Rodrigo Barbosa ◽  
Carolina Mendes ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Case Reports ◽  
Systemic Disease ◽  
Positive Family History ◽  
Rare Condition ◽  
Dual Energy ◽  
Male Athlete ◽  
Important Differential Diagnosis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Sesamoiditis secondary to gout is an extremely rare condition with few case reports in the literature. It is an important differential diagnosis because the treatment depends on targeted therapy, unlike the main causes of sesamoiditis that often involves immobilization with special orthoses and prescription of anti-inflammatory drugs. We report here a case of a 38-year-old male, athlete, with bipartite medial sesamoid, who had insidious pain in the base of the left hallux. Laboratory tests showed no alterations, and imaging examinations demonstrated sesamoiditis with suspicion of stress fracture. The patient was initially prescribed an immobilization boot and analgesic and anti-inflammatory drugs, but he did not respond to the measures taken. After the onset of the same condition in the contralateral foot and getting the same imaging findings, we began an investigation of systemic disease, focusing on gout, because of a positive family history, which was confirmed by dual-energy computed tomography.

scholarly journals Endoscopic and Pathologic Resolution of Chronic Nonsteroidal Anti-Inflammatory Drug-Induced Diaphragm-Like Colonic Strictures and Ulceration

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Behdod Poushanchi ◽  
Hiren Vallabh ◽  
Justin Kupec
Keyword(s):  
Adverse Effects ◽  
Case Reports ◽  
Nsaid Therapy ◽  
Unique Case ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chronic Use ◽  
Colonic Strictures

The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has steadily increased and, as a result, adverse effects have become more common. Isolated case reports have documented diaphragm-like colonic strictures and ulceration as the result of NSAID use. We report a unique case of this rare side effect with documented endoscopic and histologic healing of multiple proximal diaphragm-like colonic strictures and ulceration months after simple discontinuation of NSAID therapy.

scholarly journals The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine: Listen Carefully to Children with Pain

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1048
Author(s):  
Olivier Mboma ◽  
Stefan Wirth ◽  
Malik Aydin
Keyword(s):  
Case Reports ◽  
Pediatric Population ◽  
Kidney Injury ◽  
Over The Counter ◽  
High Daily Dose ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Therapeutic Recommendation ◽  
Efficacy Profile

Over the last decades, the use of over-the-counter analgesics in the general population has increased in Germany. Ibuprofen is one of the most commonly used nonsteroidal anti-inflammatory drug (NSAID) and is frequently prescribed to children as an analgesic and/or antipyretic. Besides having a well-established safety and efficacy profile when used in appropriate doses, cases of NSAID-induced acute kidney injury (AKI) have been described in the pediatric population, particularly in the context of dehydration and in combination with other drugs. The ingestion of more than 400 mg/kg is associated with severe or life-threatening toxicity. This report is about two previously healthy adolescents, who developed AKI after taking high daily dose of ibuprofen as a pain reliever without any appropriate medical supervision. With these case reports, in addition to the side effect profiles of this analgesic, we would also like to present a certain therapeutic recommendation that we applied in these patients, and furthermore appeal to pediatricians to strictly set the indications for ibuprofen intake.

Nonsteroidal anti-inflammatory drugs and necrotizing fasciitis

1996 ◽  
Vol 53 (3) ◽  
pp. 265-269 ◽  
Author(s):  
Barry A. Browne ◽  
E. Paul Holder ◽  
Leanne Rupnick
Keyword(s):  
Necrotizing Fasciitis ◽  
Scientific Literature ◽  
Case Reports ◽  
Concurrent Infection ◽  
Supportive Treatment ◽  
Affected Area ◽  
Intravenous Antibiotics ◽  
Group A ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract The clinical features, etiology, and treatment of necrotizing fasciitis are reviewed, and the possible involvement of nonsteroidal anti-inflammatory drugs (NSAIDs) in the pathogenesis of this disease is discussed. Symptoms of necrotizing fasciitis include edema, erythema, warmth, and tenderness in the affected area, spreading rapidly to involve entire limbs or portions of the abdominal wall. Gangrene may develop, followed by multi-organ failure and death. The most common causative organisms are group A beta-hemolytic streptococci. Treatment includes tissue debridement, intravenous antibiotics, and supportive treatment with fluids and electrolytes. A number of case reports and articles in the lay press have suggested an association between the use of NSAIDs and the development of necrotizing fasciitis, although this association has not been substantiated in the scientific literature. Inhibition of the immune response has been proposed as an explanation for the reported association between necrotizing fasciitis and NSAIDs. NSAIDs should be administered with caution, if at all, to patients with inflammatory soft-tissue lesions, especially if concurrent infection is likely.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

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