Ewing's Family of Tumors Involving Structures Related to the Central Nervous System: A Review

2000 ◽  
Vol 3 (3) ◽  
pp. 203-210 ◽  
Author(s):  
M. Gary Hadfield ◽  
Martha M. Quezado ◽  
Robert L. Williams ◽  
Vivian Y. Luo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Soft Tissues ◽  
Case Reports ◽  
Spinal Column ◽  
Diagnostic Methods ◽  
Electron Microscopic ◽  
Adjacent Structures ◽  
Microscopic Features ◽  
The Central Nervous System

This review consolidates information gleaned from several case reports and larger series on Ewing's sarcoma family of tumors (EFT) involving structures related to and found in the central nervous system (CNS). These tumors involve the skull, the spinal column, adjacent soft tissues, the meninges, and the brain. We have separated the cases by skull region and spinal column level, and we discuss the attendant differences in prognosis following treatment by neurosurgery, radiation, and chemotherapy. Light and electron microscopic features can be used to differentiate EFT from other small round blue cell tumors that involve the CNS (central primitive neuroectodermal tumor, lymphoma, etc.). Recent molecular and genetic findings in EFT provide new diagnostic methods. We conclude that EFT involving the CNS and adjacent structures is not so rare as previously stated and that the prognosis is more favorable, as a rule, than for the more common examples arising in the long bones and pelvis.

Desmoplastic Medulloblastoma Metastatic to the Pancreas: Case Report

Neurosurgery ◽  
1991 ◽  
Vol 29 (4) ◽  
pp. 612-616 ◽  
Author(s):  
Hendrikus G.J. Krouwer ◽  
John Vollmerhausen ◽  
Joel White ◽  
Michael D. Prados
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Soft Tissues ◽  
Extraneural Metastases ◽  
Organ Systems ◽  
Multidrug Chemotherapy ◽  
The Central Nervous System ◽  
Desmoplastic Medulloblastoma ◽  
Local Radiation ◽  
Weiss Criteria

Abstract A case is reported in which a desmoplastic medulloblastoma metastasized to the pancreas and to the surrounding soft tissues but did not recur locally or disseminate within the central nervous system. Multidrug chemotherapy and local radiation therapy resulted in a complete remission. In all four previously reported cases of medulloblastoma metastasizing to the pancreas, the diagnosis was not made until the postmortem examination, and all of these patients also had extensive metastases in other organ systems. Modification of the Weiss criteria defining extraneural metastases from tumors of the central nervous system is suggested.

Paediatrische Radiologie: Stützgewebe-Zentralnervensystem-Syndrome, Vol. I, by Franz Schmid. Berlin/Heidelberg/New York: Springer-Verlag, 1972, 504 pp., $78.70

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 630-631
Author(s):  
Edward B. D. Neuhauser
Keyword(s):  
New York ◽  
Central Nervous System ◽  
Nervous System ◽  
Pediatric Radiology ◽  
Soft Tissues ◽  
Full Time ◽  
The Central Nervous System

Only the first volume of this projected two-volume textbook of pediatric radiology is available for review. Included in the first volume is a discussion of bones and soft tissues, the central nervous system, and 100 pages of syndromes in brief tabulated form. This is a handsome book written in German with 451 excellent illustrations. Few of the 16 contributing authors are well known in this country and it would seem that few are full-time pediatric radiologists.

scholarly journals Lucien J. Rubinstein: enduring contributions to neuro-oncology

2005 ◽  
Vol 18 (4) ◽  
pp. 1-11 ◽  
Author(s):  
Melike Mut ◽  
M. Beatriz S. Lopes ◽  
Mark Shaffrey
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Cultures ◽  
Tumor Biology ◽  
Cns Tumors ◽  
Electron Microscopic ◽  
Diagnostic Investigation ◽  
Nervous System Tumors ◽  
Microscopic Features

Dr. Lucien Rubinstein is best remembered for his significant contributions to the field of neuropathology, particularly in the classification of nervous system tumors. His accomplishments in basic neuro-oncology and in the formulation of diagnostic principles reflected a unique talent for synthesizing fundamental clinicopathological concepts based on skillful diagnostic investigation and a thorough understanding of neurobiology. Dr. Rubinstein was the leader in the establishment of cell cultures from central nervous system (CNS) tumors. He meticulously analyzed both light and electron microscopic features of CNS tumors, recorded his findings, and patiently drew sketches to be shared generously with his colleagues and students. As a pioneer in neuropathology, in his work Dr. Rubinstein set the foundation for many enduring concepts in neurosurgery, neuro-oncology, neurology, and basic tumor biology.

Toxoplasmosis of the central nervous system in the adult. Electron microscopic observations

1978 ◽  
Vol 41 (3) ◽  
pp. 211-216 ◽  
Author(s):  
H. C. Powell ◽  
C. J. Gibbs ◽  
A. M. Lorenzo ◽  
P. W. Lampert ◽  
D. C. Gajdusek
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electron Microscopic ◽  
The Central Nervous System

Effects of Nicergoline on Calcium and Magnesium Deposition in the Central Nervous System Tissues of Rats Maintained on Low-Calcium Diets

1992 ◽  
Vol 20 (6) ◽  
pp. 483-491 ◽  
Author(s):  
M Yasui ◽  
T Kihira ◽  
M Tsujimoto ◽  
K Ota
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Soft Tissues ◽  
Cerebral Metabolism ◽  
Calcium Deposition ◽  
Standard Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
The Central Nervous System ◽  
Calcium And Magnesium

Reduction of calcium intake leads to the mobilization of calcium and magnesium from the bone pool and to calcium deposition in the soft tissues, especially in the central nervous system (CNS). The effects of 10α-methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate (nicergoline), an ameliorator of cerebral circulation and metabolism, on the deposition of calcium and magnesium in the CNS, heart, liver, kidney, muscle, abdominal aorta and bones were studied in rats maintained on standard and low-calcium diets. Rats were fed the following diets for 90 days: standard calcium (12.5 g/kg); standard calcium with 60 mg/kg nicergoline; low-calcium (30 mg/kg); and low-calcium with 60 mg/kg nicergoline. The presence of nicergoline did not affect blood chemistry but magnesium concentrations in the liver were significantly (P < 0.05) higher in rats fed standard diet with nicergoline. Magnesium concentrations in the occipital cortex, pons, cerebellum, liver, kidney, muscle and femur of nicergoline-treated rats fed low-calcium diet were significantly ( P < 0.01 − 0.05) higher compared with those in the corresponding controls, whereas the calcium concentrations in the femur of nicergoline-treated rats fed both standard and low-calcium diets were significantly ( P < 0.05) higher than those in the corresponding controls. In general, nicergoline tended to preserve the calcium content in the bone of rats fed a standard diet. Nicergoline may be implicated in calcium metabolism in rats fed low-calcium diets and may activate cerebral metabolism through the maintenance of magnesium concentrations in the CNS and soft tissues.

scholarly journals Primary Angiitis of the Central Nervous System: A Report of Three Cases from a Single Colombian Center

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Nicolás Coronel-Restrepo ◽  
Fabio Bonilla-Abadía ◽  
Omar A. Cortes ◽  
Jorge H. Izquierdo ◽  
Alberto M. Shinchi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Reports ◽  
Clinical Manifestations ◽  
Brain Biopsy ◽  
System A ◽  
Primary Angiitis ◽  
The Central Nervous System ◽  
Systemic Manifestations ◽  
Low Incidence

The primary angiitis of the central nervous system (PACNS) is an entity with a very low incidence and prevalence. It is not clear why the inflammatory process of this entity is limited to the cerebral vasculature without systemic manifestations. Its clinical manifestations are very heterogeneous and make clinical diagnosis difficult. In most cases, a brain biopsy is required. Only the clinical suspicion and the ability to recognize the possible clinical and imagenological patterns of presentation make an accurate diagnosis possible. The vast majority of the treatment recommendations are given by series of case reports. The following paper described the clinical, imagenological, and histopathological characteristics of three Colombian patients with PACNS. The strategic therapeutic used in shown.

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