Measurement of bone mineral density of lumbar spine and whole body in low-birth-weight infants: comparison of two methods

2001 ◽  
Vol 19 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Hiroyuki Ichiba ◽  
Chie Hirai ◽  
Mutsuko Fujimaru ◽  
Haruo Shintaku ◽  
Tsunekazu Yamano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Low Birth Weight ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Low Birth Weight Infants

Bone mineral density of the lumbar spine in very-low-birth-weight infants: a longitudinal study

2000 ◽  
Vol 159 (3) ◽  
pp. 215-218 ◽  
Author(s):  
H. Ichiba ◽  
H. Shintaku ◽  
M. Fujimaru ◽  
C. Hirai ◽  
Y. Okano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Low Birth Weight ◽  
Bone Mineral ◽  
Very Low Birth Weight ◽  
Mineral Density ◽  
Low Birth Weight Infants

scholarly journals Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

2009 ◽  
Vol 127 (5) ◽  
pp. 278-282 ◽  
Author(s):  
Maria Eugênia Farias Almeida Motta ◽  
Maria Eduarda Nóbrega de Faria ◽  
Gisélia Alves Pontes da Silva
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Gluten Free Diet ◽  
Whole Body ◽  
Chronological Age ◽  
Gluten Free ◽  
Mineral Density ◽  
Low Bone Mineral Density

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING: Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira. METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm²) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet. RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION: Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.

scholarly journals Identification of Potential Novel Pleiotropic Susceptibility Variants Common To Lumbar Spine Bone Mineral Density And Birth Weight

2021 ◽  
Author(s):  
Yu-Qian Song ◽  
Shi-Di Hu ◽  
Xu Lin ◽  
Xiang-He Meng ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Epidemiological Studies ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Genome Wide ◽  
Genetic Mechanisms

Abstract An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes (NTAN1, PDXDC1, CACNA1G, JAG1, FAT1P1, CCDC170, ESR1), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1, supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development.

scholarly journals Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

2020 ◽  
Author(s):  
Kexun Chen ◽  
Shiou-Liang Wee ◽  
Benedict Wei Jun Pang ◽  
Lay Khoon Lau ◽  
Khalid Abdul Jabbar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Reference Values ◽  
World Health ◽  
Whole Body ◽  
Kappa Statistics ◽  
Mineral Density ◽  
Percentage Difference ◽  
Prevalence Of Osteoporosis

Abstract Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults.Methods: We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

scholarly journals Bone mineral density reference values in Singaporean adults and comparison for osteoporosis establishment – The Yishun Study

2020 ◽  
Author(s):  
Kexun Chen ◽  
Shiou-Liang Wee ◽  
Benedict Wei Jun Pang ◽  
Lay Khoon Lau ◽  
Khalid Abdul Jabbar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Reference Values ◽  
World Health ◽  
Whole Body ◽  
Kappa Statistics ◽  
Mineral Density ◽  
Percentage Difference ◽  
Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively.  The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

scholarly journals Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Kexun Kenneth Chen ◽  
Shiou-Liang Wee ◽  
Benedict Wei Jun Pang ◽  
Lay Khoon Lau ◽  
Khalid Abdul Jabbar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Reference Values ◽  
World Health ◽  
Whole Body ◽  
Kappa Statistics ◽  
Mineral Density ◽  
Percentage Difference ◽  
Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093 ± 0.168 g/cm2 in women, and 1.041 ± 0.098 g/cm2 for men. Peak whole-body BMD was 1.193 ± 0.93 g/cm2 in women at, and 1.224 ± 0.112 g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5–163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively.  The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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