Bone mineral density of the lumbar spine in very-low-birth-weight infants: a longitudinal study

2000 ◽  
Vol 159 (3) ◽  
pp. 215-218 ◽  
Author(s):  
H. Ichiba ◽  
H. Shintaku ◽  
M. Fujimaru ◽  
C. Hirai ◽  
Y. Okano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Low Birth Weight ◽  
Bone Mineral ◽  
Very Low Birth Weight ◽  
Mineral Density ◽  
Low Birth Weight Infants

Measurement of bone mineral density of lumbar spine and whole body in low-birth-weight infants: comparison of two methods

2001 ◽  
Vol 19 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Hiroyuki Ichiba ◽  
Chie Hirai ◽  
Mutsuko Fujimaru ◽  
Haruo Shintaku ◽  
Tsunekazu Yamano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Low Birth Weight ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Low Birth Weight Infants

scholarly journals Decreased Bone Mineral Density in Adults Born with Very Low Birth Weight: A Cohort Study

PLoS Medicine ◽  
2009 ◽  
Vol 6 (8) ◽  
pp. e1000135 ◽  
Author(s):  
Petteri Hovi ◽  
Sture Andersson ◽  
Anna-Liisa Järvenpää ◽  
Johan G. Eriksson ◽  
Sonja Strang-Karlsson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Bone Mineral ◽  
Very Low Birth Weight ◽  
Mineral Density

scholarly journals SAT0477 A TWO-YEAR LONGITUDINAL STUDY COMPLETION, LONGITUNEAL STUDY, THE DIFFERENCE IN BONE LOSS IN PATIENTS WITH EROSIVE AND NON-EROSIVE HAND OSTEOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1195.2-1195
Author(s):  
K. Pavelka ◽  
L. Šenolt ◽  
O. Sleglova ◽  
J. Baloun ◽  
O. Růžičková
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Bone Mineral ◽  
Hand Osteoarthritis ◽  
Mineral Density ◽  
Erosive Disease ◽  
Femur Neck ◽  
American College Of Rheumatology

Background:Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain and morbidity. Some metabolic factors were suggested to be implicated in erosive disease. Few studies investigated differences in systemic bone loss between erosive and non-erosive hand OA.Objectives:To compare the change of bone mineral density (BMD) between patients with erosive and non-erosive hand OA in a two-year longitudinal study.Methods:Consecutive patients with symptomatic HOA fulfilling the American College of Rheumatology (ACR) criteria were included in this study. Erosive hand OA was defined by at least one erosive interphalangeal joint. All patients underwent clinical assessments of joint swelling and radiographs of both hands. DEXA examination of lumbar spine, total femur and femur neck was performed at the baseline and after two years.Results:Altogether, 141patients (15 male) with symptomatic nodal HOA were included in this study and followed between April 2012 and January 2019. Out of these patients, 80 had erosive disease after two years. The disease duration (p<0.01) was significantly higher in patients with erosive compared with non-erosive disease at baseline.Osteoporosis (T-score <-2.5 SD) was diagnosed in 12.5% (9/72) of patients with erosive hand OA and in 8.06% (5/57) of patients with non-erosive hand OA at baseline. BMD was significantly lowered in patients with erosive compared with non-erosive disease at baseline (lumbar spine: 1.05g/cm2 vs. 1.13 g/cm2, p<0.05, total femur: 0.90 g/cm2 vs. 0.97 g/cm2, p<0.01 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05). T-scores of lumbar spine (-0.96 vs. -0.41 SD, p<0.05), total femur (-0.69 vs. -0.33 SD, p<0.05) and femur neck (-1.14 vs. -0.88 SD, p<0.05) were also significantly lowered in patients with erosive compared with non-erosive disease.Two years, the BMD remained also significantly lowered in patients with erosive compared with non-erosive disease (lumbar spine: 1.05g/cm2 vs. 1.14 g/cm2, p<0.05, total femur: 0.92 g/cm2 vs. 0.97 g/cm2, p<0.05 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05), which was in agreement with the finding for T-scores of lumbar spine (-1.05 vs. -0.39 SD, p<0.05), total femur (-0.74 vs. -0.34 SD, p<0.01) and femur neck (-1.07 vs. -0.72 SD, p<0.01).Conclusion:These results suggest that patients with erosive hand OA are at higher risk for the development of general bone loss. Over two years patients with erosive disease had significant lower bone mineral density at all measured sites.References:[1]This work was supported by the project AZV no. 18-00542 and MHCR No. 023728.Acknowledgments:Project AZV no. 18-00542 and MHCR No. 023728Disclosure of Interests:Karel Pavelka Consultant of: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Speakers bureau: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Ladislav Šenolt: None declared, Olga Sleglova: None declared, Jiří Baloun: None declared, Olga Růžičková: None declared

scholarly journals Identification of Potential Novel Pleiotropic Susceptibility Variants Common To Lumbar Spine Bone Mineral Density And Birth Weight

2021 ◽  
Author(s):  
Yu-Qian Song ◽  
Shi-Di Hu ◽  
Xu Lin ◽  
Xiang-He Meng ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Epidemiological Studies ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Genome Wide ◽  
Genetic Mechanisms

Abstract An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes (NTAN1, PDXDC1, CACNA1G, JAG1, FAT1P1, CCDC170, ESR1), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1, supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development.

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