Effect of vitamin K 2 (menaquinone-7) in fermented soybean ( natto ) on bone loss in ovariectomized rats

1999 ◽  
Vol 17 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Masayoshi Yamaguchi ◽  
Hideaki Taguchi ◽  
Ying Hua Gao ◽  
Aki Igarashi ◽  
Yoshinori Tsukamoto
Keyword(s):  
Bone Loss ◽  
Vitamin K ◽  
Ovariectomized Rats ◽  
Fermented Soybean

Prolonged intake of fermented soybean ( natto ) diets containing vitamin K 2 (menaquinone-7) prevents bone loss in ovariectomized rats

2000 ◽  
Vol 18 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Masayoshi Yamaguchi ◽  
Hiroyuki Kakuda ◽  
Ying Hua Gao ◽  
Yoshinori Tsukamoto
Keyword(s):  
Bone Loss ◽  
Vitamin K ◽  
Ovariectomized Rats ◽  
Fermented Soybean

scholarly journals Preventive Effect of Dietary Fermented Soybean on Bone Loss in Ovariectomized Rats. Enhancement with Isoflavone and Zinc Supplementation.

2000 ◽  
Vol 46 (4) ◽  
pp. 263-268 ◽  
Author(s):  
Zhong Jie Ma ◽  
Shigefumi Shimanuki ◽  
Aki Igarashi ◽  
Yoshiyuki Kawasaki ◽  
Masayoshi Yamaguchi
Keyword(s):  
Bone Loss ◽  
Zinc Supplementation ◽  
Ovariectomized Rats ◽  
Preventive Effect ◽  
Fermented Soybean

scholarly journals Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats

2011 ◽  
Vol 212 (2) ◽  
pp. 179-186 ◽  
Author(s):  
Rana Samadfam ◽  
Malaika Awori ◽  
Agnes Bénardeau ◽  
Frieder Bauss ◽  
Elena Sebokova ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Combination Treatment ◽  
Mass Gain ◽  
Ovariectomized Rats ◽  
Concomitant Treatment ◽  
Mineral Density ◽  
Ovx Rats

Peroxisome proliferator-activated receptor (PPAR) γ agonists, such as pioglitazone (Pio), improve glycemia and lipid profile but are associated with bone loss and fracture risk. Data regarding bone effects of PPARα agonists (including fenofibrate (Feno)) are limited, although animal studies suggest that Feno may increase bone mass. This study investigated the effects of a 13-week oral combination treatment with Pio (10 mg/kg per day)+Feno (25 mg/kg per day) on body composition and bone mass parameters compared with Pio or Feno alone in adult ovariectomized (OVX) rats, with a 4-week bone depletion period, followed by a 6-week treatment-free period. Treatment of OVX rats with Pio+Feno resulted in ∼50% lower fat mass gain compared with Pio treatment alone. Combination treatment with Pio+Feno partially prevented Pio-induced loss of bone mineral content (∼45%) and bone mineral density (BMD; ∼60%) at the lumbar spine. Similar effects of treatments were observed at the femur, most notably at sites rich in trabecular bone. At the proximal tibial metaphysis, concomitant treatment with Pio+Feno prevented Pio exacerbation of ovariectomy-induced loss of trabecular bone, resulting in BMD values in the Pio+Feno group comparable to OVX controls. Discontinuation of Pio or Feno treatment of OVX rats was associated with partial reversal of effects on bone loss or bone mass gain, respectively, while values in the Pio+Feno group remained comparable to OVX controls. These data suggest that concurrent/dual agonism of PPARγ and PPARα may reduce the negative effects of PPARγ agonism on bone mass.

scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2 O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats

2015 ◽  
Vol 230 (9) ◽  
pp. 2184-2201 ◽  
Author(s):  
Chao Fu ◽  
Dong Xu ◽  
Chang-Yuan Wang ◽  
Yue Jin ◽  
Qi Liu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Lipoic Acid ◽  
Ovariectomized Rats ◽  
Alpha Lipoic Acid

scholarly journals Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats

2015 ◽  
Vol 18 (12) ◽  
pp. 1349-1356 ◽  
Author(s):  
Jonggun Kim ◽  
Hyung Kwan Kim ◽  
Saehun Kim ◽  
Ji-Young Imm ◽  
Kwang-Youn Whang
Keyword(s):  
Bone Loss ◽  
Whey Protein ◽  
Ovariectomized Rats ◽  
Whey Protein Concentrate ◽  
Protein Concentrate

scholarly journals Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment

2008 ◽  
Vol 67 (2) ◽  
pp. 163-176 ◽  
Author(s):  
Susan A. Lanham-New
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Vitamin K ◽  
Hypovitaminosis D ◽  
Osteoporosis Prevention ◽  
Mineral Density ◽  
Increased Risk ◽  
Post Menopause ◽  
Exogenous Factors ◽  
The Uk

Throughout the life cycle the skeleton requires optimum development and maintenance of its integrity to prevent fracture. Bones break because the loads placed on them exceed the ability of the bone to absorb the energy involved. It is now estimated that one in three women and one in twelve men aged >55 years will suffer from osteoporosis in their lifetime and at a cost in the UK of >£1·7×109 per year. The pathogenesis of osteoporosis is multifactorial. Both the development of peak bone mass and the rate of bone loss are determined by key endogenous and exogenous factors. Ca supplements appear to be effective in reducing bone loss in women late post menopause (>5 years post menopause), particularly in those with low habitual Ca intake (<400 mg/d). In women early post menopause (<5 years post menopause) who are not vitamin D deficient, Ca supplementation has little effect on bone mineral density. However, supplementation with vitamin D and Ca has been shown to reduce fracture rates in the institutionalised elderly, but there remains controversy as to whether supplementation is effective in reducing fracture in free-living populations. Re-defining vitamin D requirements in the UK is needed since there is evidence of extensive hypovitaminosis D in the UK. Low vitamin D status is associated with an increased risk of falling and a variety of other health outcomes and is an area that requires urgent attention. The role of other micronutrients on bone remains to be fully defined, although there are promising data in the literature for a clear link between vitamin K nutrition and skeletal integrity, including fracture reduction.

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