Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-β1-mediated growth inhibition

1999 ◽  
Vol 144 (2) ◽  
pp. 241-257 ◽  
Author(s):  
M. Takanashi ◽  
J. Li ◽  
M. Shirakata ◽  
S. Mori ◽  
K. Hirai
Keyword(s):  
Growth Factor ◽  
Growth Inhibition ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Normal Growth ◽  
Transforming Growth Factor Β1 ◽  
Fibroblast Cells ◽  
Barr Virus ◽  
Epstein Barr

Cytokine levels in patients with Epstein–Barr virus associated laryngeal carcinoma

2010 ◽  
Vol 124 (9) ◽  
pp. 990-994 ◽  
Author(s):  
S Rota ◽  
I Fidan ◽  
T Muderris ◽  
E Yesilyurt ◽  
Z Lale
Keyword(s):  
Growth Factor ◽  
Laryngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Barr Virus ◽  
Cytokine Levels ◽  
Epstein Barr

AbstractObjective:Some researchers have suggested that Epstein–Barr virus may play a role in the pathogenesis of laryngeal malignancies. In order to clarify the role of cytokines in this disease context, the current study aimed to determine the serum levels of cytokines in Epstein–Barr virus DNA positive patients with laryngeal carcinoma.Subjects:The study included 10 patients with diagnosed laryngeal carcinoma and Epstein–Barr virus DNA positive tumour tissue samples. The control group comprised 10 Epstein–Barr virus DNA negative patients diagnosed with laryngeal carcinoma, 10 patients with acute Epstein–Barr virus infection and 10 healthy individuals.Method:Serum cytokine levels were determined by enzyme-linked immunosorbent assay.Results:The Epstein–Barr virus DNA positive and negative laryngeal carcinoma patients showed no differences regarding serum levels of the following cytokines: interleukins 1β, 2, 6 and 12, tumour necrosis factor α, and interferon γ. However, serum levels of interleukin 10 and transforming growth factor β1 were significantly higher in Epstein–Barr virus DNA positive laryngeal carcinoma patients compared with Epstein–Barr virus DNA negative laryngeal carcinoma patients (p < 0.05).Conclusion:Our results suggest that the cytokines interleukin 10 and transforming growth factor β1 may act as growth factors in Epstein–Barr virus related laryngeal carcinoma. These cytokines may thus represent potential targets for molecular therapeutic treatment for laryngeal carcinoma; they may also be useful as indicators of disease prognosis.

Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers

2008 ◽  
Vol 128 (10) ◽  
pp. 1145-1151 ◽  
Author(s):  
Hong-Wen Chen ◽  
Sheau-Fang Yang ◽  
Yue-Cune Chang ◽  
Tao-Yeung Wang ◽  
Yu-Jen Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Virus Infection ◽  
Head And Neck ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals A Mechanism in Epstein–Barr Virus Oncogenesis: Inhibition of Transforming Growth Factor-β1-mediated Induction of MAPK/p21 by LMP1

Virology ◽  
2002 ◽  
Vol 302 (2) ◽  
pp. 310-320 ◽  
Author(s):  
Makoto Fukuda ◽  
Wataru Kurosaki ◽  
Kazuyoshi Yanagihara ◽  
Hirohiko Kuratsune ◽  
Takeshi Sairenji
Keyword(s):  
Growth Factor ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

2000 ◽  
Vol 74 (5) ◽  
pp. 2443-2446 ◽  
Author(s):  
Jingwu Xu ◽  
Ali Ahmad ◽  
James F. Jones ◽  
Riccardo Dolcetti ◽  
Emanuela Vaccher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Transforming Growth Factor Β ◽  
Serum Levels ◽  
Barr Virus ◽  
Associated Diseases ◽  
Epstein Barr

ABSTRACT Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV-specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

Glucocorticoids promote the proliferation and antagonize the retinoic acid–mediated growth suppression of Epstein-Barr virus–immortalized B lymphocytes

Blood ◽  
2000 ◽  
Vol 96 (2) ◽  
pp. 711-718 ◽  
Author(s):  
Michele Quaia ◽  
Paola Zancai ◽  
Roberta Cariati ◽  
Silvana Rizzo ◽  
Mauro Boiocchi ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
Epstein Barr Virus ◽  
Therapeutic Potential ◽  
Growth Arrest ◽  
Barr Virus ◽  
Immunosuppressed Patients ◽  
Epstein Barr

Abstract Glucocorticoids are able to release Epstein-Barr virus–immortalized (EBV-immortalized) lymphoblastoid B cell lines (LCLs) from the persistent growth arrest induced in these cells by retinoic acid (RA). Moreover, physiologic concentrations of glucocorticoids efficiently antagonized LCL growth inhibition induced by 13-cis-RA; 9-cis-RA; all-trans-RA; and Ro 40-6055, an RA  receptor (RAR) selective agonist. RAR expression levels, however, were not affected by glucocorticoids. Glucocorticoids, but not other steroid hormones, directly promote LCL proliferation, a phenomenon that was mainly mediated by down-regulation of the cyclin-dependent kinase (CDK) inhibitor p27Kip-1. Moreover, glucocorticoids contrasted the up-regulation of p27Kip-1, which was underlying the RA-induced LCL growth arrest, thereby indicating that glucocorticoids and RA signalings probably converge on p27Kip-1. Both antagonism of RA-mediated growth inhibition and promotion of LCL proliferation were efficiently reversed by the glucocorticoid receptor (GR) antagonist RU486, indicating that all of these effects were mediated by GR. Of note, RU486 also proved to be effective in vivo and, in mice, was able to significantly inhibit the growth of untreated LCLs as well as LCLs growth-arrested by RA in vitro. These findings provide a rational background to further evaluate the possible role of glucocorticoids in the pathogenesis of EBV-related lymphoproliferations of immunosuppressed patients. Moreover, GR antagonists deserve further consideration for their possible efficacy in the management of these disorders, and the use of schedules, including both RA and a GR antagonist, may allow a more thorough evaluation of the therapeutic potential of RA in this setting.

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