scholarly journals Effect of Transforming Growth Factor-β1 on the Cell Growth and Epstein–Barr Virus Reactivation in EBV-Infected Epithelial Cell Lines

Virology ◽  
2001 ◽  
Vol 288 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Makoto Fukuda ◽  
Kazufumi Ikuta ◽  
Kazuyoshi Yanagihara ◽  
Masako Tajima ◽  
Hirohiko Kuratsune ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Virus Reactivation ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Epstein Barr ◽  
Infected Epithelial Cell ◽  
Epstein Barr Virus Reactivation

Cytokine levels in patients with Epstein–Barr virus associated laryngeal carcinoma

2010 ◽  
Vol 124 (9) ◽  
pp. 990-994 ◽  
Author(s):  
S Rota ◽  
I Fidan ◽  
T Muderris ◽  
E Yesilyurt ◽  
Z Lale
Keyword(s):  
Growth Factor ◽  
Laryngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Barr Virus ◽  
Cytokine Levels ◽  
Epstein Barr

AbstractObjective:Some researchers have suggested that Epstein–Barr virus may play a role in the pathogenesis of laryngeal malignancies. In order to clarify the role of cytokines in this disease context, the current study aimed to determine the serum levels of cytokines in Epstein–Barr virus DNA positive patients with laryngeal carcinoma.Subjects:The study included 10 patients with diagnosed laryngeal carcinoma and Epstein–Barr virus DNA positive tumour tissue samples. The control group comprised 10 Epstein–Barr virus DNA negative patients diagnosed with laryngeal carcinoma, 10 patients with acute Epstein–Barr virus infection and 10 healthy individuals.Method:Serum cytokine levels were determined by enzyme-linked immunosorbent assay.Results:The Epstein–Barr virus DNA positive and negative laryngeal carcinoma patients showed no differences regarding serum levels of the following cytokines: interleukins 1β, 2, 6 and 12, tumour necrosis factor α, and interferon γ. However, serum levels of interleukin 10 and transforming growth factor β1 were significantly higher in Epstein–Barr virus DNA positive laryngeal carcinoma patients compared with Epstein–Barr virus DNA negative laryngeal carcinoma patients (p < 0.05).Conclusion:Our results suggest that the cytokines interleukin 10 and transforming growth factor β1 may act as growth factors in Epstein–Barr virus related laryngeal carcinoma. These cytokines may thus represent potential targets for molecular therapeutic treatment for laryngeal carcinoma; they may also be useful as indicators of disease prognosis.

Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers

2008 ◽  
Vol 128 (10) ◽  
pp. 1145-1151 ◽  
Author(s):  
Hong-Wen Chen ◽  
Sheau-Fang Yang ◽  
Yue-Cune Chang ◽  
Tao-Yeung Wang ◽  
Yu-Jen Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Virus Infection ◽  
Head And Neck ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals A Mechanism in Epstein–Barr Virus Oncogenesis: Inhibition of Transforming Growth Factor-β1-mediated Induction of MAPK/p21 by LMP1

Virology ◽  
2002 ◽  
Vol 302 (2) ◽  
pp. 310-320 ◽  
Author(s):  
Makoto Fukuda ◽  
Wataru Kurosaki ◽  
Kazuyoshi Yanagihara ◽  
Hirohiko Kuratsune ◽  
Takeshi Sairenji
Keyword(s):  
Growth Factor ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Barr Virus ◽  
Epstein Barr

Valganciclovir suppressed Epstein Barr virus reactivation during immunosuppression with alemtuzumab

2014 ◽  
Vol 59 (4) ◽  
pp. 255-258 ◽  
Author(s):  
Harinder Gill ◽  
Yu-Yan Hwang ◽  
Thomas S.Y. Chan ◽  
Annie W.K. Pang ◽  
Anskar Y.H. Leung ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Virus Reactivation ◽  
Barr Virus ◽  
Epstein Barr ◽  
Epstein Barr Virus Reactivation
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