A sensitive PCR assay system for the quantitation of viral genome equivalents: human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)

1997 ◽  
Vol 142 (7) ◽  
pp. 1297-1306 ◽  
Author(s):  
T. Hämmerle ◽  
M. Himmelspach ◽  
F. Dorner ◽  
F. G. Falkner
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Viral Genome ◽  
Pcr Assay ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Hiv 1

scholarly journals Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

2007 ◽  
Vol 51 (10) ◽  
pp. 3505-3509 ◽  
Author(s):  
George R. Painter ◽  
Merrick R. Almond ◽  
Lawrence C. Trost ◽  
Bernhard M. Lampert ◽  
Johan Neyts ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Target Cells ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Oral Availability ◽  
Hiv 1

ABSTRACT 9-R-[2-(Phosphonomethoxy)propyl]-adenine (tenofovir) is an acyclic nucleoside phosphonate with antiviral activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). Tenofovir is not orally bioavailable but becomes orally active against HIV-1 infection as the disoproxil ester (tenofovir disoproxil fumarate [Viread]). We have developed an alternative strategy for promoting the oral availability of nucleoside phosphonate analogs which involves esterification with a lipid to form a lysolecithin mimic. This mimic can utilize natural lysolecithin uptake pathways in the gut, resulting in high oral availability. Since the mimic is not subject to cleavage in the plasma by nonspecific esterases, it remains intact in the circulation and facilitates uptake by target cells. Significant drops in apparent antiviral 50% effective concentrations (EC50s) of up to 3 logs have been observed in comparison with non-lipid-conjugated parent compounds in target cells. We have applied this technology to tenofovir with the goal of increasing oral availability, decreasing the apparent EC50, and decreasing the potential for nephrotoxicity by reducing the exposure of the kidney to the free dianionic tenofovir. Here we report that, in vitro, the hexadecyloxypropyl ester of tenofovir, CMX157, is 267-fold more active than tenofovir against HIV-1 and 4.5-fold more active against HBV. CMX157 is orally available and has no apparent toxicity when given orally to rats for 7 days at doses of 10, 30, or 100 mg/kg/day. Consequently, CMX157 represents a second-generation tenofovir analog which may have an improved clinical profile.

scholarly journals Synthesis of 4′-Substituted Purine 2′-Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus

2018 ◽  
Vol 3 (11) ◽  
pp. 3313-3317 ◽  
Author(s):  
Satoru Kohgo ◽  
Shuhei Imoto ◽  
Ryoh Tokuda ◽  
Yuki Takamatsu ◽  
Nobuyo Higashi-Kuwata ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
B Virus ◽  
Immunodeficiency Virus

Reappearance of Hepatitis B Virus in Immune Patients Infected with the Human Immunodeficiency Virus Type 1

1988 ◽  
Vol 158 (3) ◽  
pp. 666-667 ◽  
Author(s):  
Y. Lazizi ◽  
L. G. Keros ◽  
J.-F. Delfraissy ◽  
F. Boue ◽  
P. Dubreuil ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
B Virus ◽  
Immunodeficiency Virus

Physician Satisfaction With Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Testing in San Diego County

Medical Care ◽  
1996 ◽  
Vol 34 (1) ◽  
pp. 1-10 ◽  
Author(s):  
JYOTI RAU ◽  
JULIE L. CROSS ◽  
LOUISE K. HOFHERR ◽  
K. MICHAEL PEDDECORD ◽  
ABRAM S. BENENSON ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Physician Satisfaction ◽  
San Diego County ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Virus Testing

Comparisons of DNA-mediated immunization procedures directed against surface glycoproteins of human immunodeficiency virus type-1 and hepatitis B virus

Apmis ◽  
1998 ◽  
Vol 106 (1-6) ◽  
pp. 636-646 ◽  
Author(s):  
ANDERS FOMSGAARD ◽  
HENRIK VEDEL NIELSEN ◽  
CLAUS NIELSEN ◽  
KARIN JOHANSSON ◽  
ROBERTO MACHUCA ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Surface Glycoproteins
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