Ultrasensitive amperometric immunosensor for the prostate specific antigen by exploiting a Fenton reaction induced by a metal-organic framework nanocomposite of type Au/Fe-MOF with peroxidase mimicking activity

2020 ◽  
Vol 187 (1) ◽  
Author(s):  
Jiejie Feng ◽  
Huiqiang Wang ◽  
Zhanfang Ma
Keyword(s):  
Prostate Specific Antigen ◽  
Fenton Reaction ◽  
Metal Organic Framework ◽  
Specific Antigen ◽  
Amperometric Immunosensor ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

2021 ◽  
Author(s):  
Amal S. Basaleh ◽  
S. M. El-Sheikh
Keyword(s):  
Prostate Specific Antigen ◽  
Metal Organic Framework ◽  
Specific Antigen ◽  
Interaction Mechanism ◽  
Optical Biosensor ◽  
Human Beings ◽  
Vis Spectroscopy ◽  
Metal Organic ◽  
Ft Ir ◽  
Organic Framework

Abstract PSA, abbreviated of “Prostate-Specific Antigen” is widely used as a considered a significant cancer biomarker for diagnosing prostate cancer. Improvement of a fast, facile, and less cost with high accurate/sensitive/selective methodologies for the PSA determination is stock-still a challenge. In this work, we reported a simple biosensor based on a Zn(II) metal-organic framework nanoparticles (Zn-MOF-NPs) derived from reaction of zinc acetate with nano organic linker. The structure, morphology, and physicochemical properties of the prepared Zn(II)-MOF-NPs were definite using various spectroscopic and microanalytical tools as SEM-EDX, HR-TEM, XRD, XPS, elemental analysis, FT-IR, UV-vis spectroscopy, mass spectroscopy, thermogravimetric Analysis (DSC/TGA), and photoluminescence (PL). Obviously, the results revealed that the Zn(II)-MOF-NPs is chemical stable, highly selective and sensitive to PSA, without interferences with other common interfering analytes. The detection limit for PSA was 0.145 fg/mL, in a wide-linear range of concentrations (0.1 fg/mL-20 pg/mL), with a correlation coefficient 0.983. The Zn(II)-MOF-NPs was successfully used as an up-and-coming biosensor for PSA-monitoring and quantification in biological real samples (plasma/whole blood/serum) at clinical target concentration levels. Moreover, the present approach will help the human-beings from the hazard’s prostatic cancer through early discovery and diagnosis process via the detection of PSA at low limits of concentrations. Meantime, the interaction mechanism between the Zn(II)-MOF-NPs and PSA was well studied and investigated.

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Magnetic Ordering via Itinerant Ferromagnetism in a Metal-Organic Framework

2020 ◽  
Author(s):  
Jesse Park ◽  
Brianna Collins ◽  
Lucy Darago ◽  
Tomce Runcevski ◽  
Michael Aubrey ◽  
...  
Keyword(s):  
Charge Transport ◽  
Magnetic Order ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Magnetic Ordering ◽  
Double Exchange ◽  
Itinerant Ferromagnetism ◽  
Organic Solids ◽  
Metal Organic ◽  
Organic Framework

<b>Materials that combine magnetic order with other desirable physical attributes offer to revolutionize our energy landscape. Indeed, such materials could find transformative applications in spintronics, quantum sensing, low-density magnets, and gas separations. As a result, efforts to design multifunctional magnetic materials have recently moved beyond traditional solid-state materials to metal–organic solids. Among these, metal–organic frameworks in particular bear structures that offer intrinsic porosity, vast chemical and structural programmability, and tunability of electronic properties. Nevertheless, magnetic order within metal–organic frameworks has generally been limited to low temperatures, owing largely to challenges in creating strong magnetic exchange in extended metal–organic solids. Here, we employ the phenomenon of itinerant ferromagnetism to realize magnetic ordering at <i>T</i><sub>C</sub> = 225 K in a mixed-valence chromium(II/III) triazolate compound, representing the highest ferromagnetic ordering temperature yet observed in a metal–organic framework. The itinerant ferromagnetism is shown to proceed via a double-exchange mechanism, the first such observation in any metal–organic material. Critically, this mechanism results in variable-temperature conductivity with barrierless charge transport below <i>T</i><sub>C</sub> and a large negative magnetoresistance of 23% at 5 K. These observations suggest applications for double-exchange-based coordination solids in the emergent fields of magnetoelectrics and spintronics. Taken together, the insights gleaned from these results are expected to provide a blueprint for the design and synthesis of porous materials with synergistic high-temperature magnetic and charge transport properties. </b>

Solvent-Free Powder Synthesis and MOF-CVD Thin Films of the Mesoporous Metal-Organic Framework MAF-6

2019 ◽  
Author(s):  
Timothée Stassin ◽  
Ivo Stassen ◽  
Joao Marreiros ◽  
Alexander John Cruz ◽  
Rhea Verbeke ◽  
...  
Keyword(s):  
Vapor Phase ◽  
Metal Organic Framework ◽  
Chemical Vapor ◽  
Uptake Capacity ◽  
Powder Synthesis ◽  
Crystalline Films ◽  
Metal Organic ◽  
Mesoporous Metal ◽  
First Time ◽  
Organic Framework

A simple solvent- and catalyst-free method is presented for the synthesis of the mesoporous metal-organic framework (MOF) MAF-6 (RHO-Zn(eIm)2) based on the reaction of ZnO with 2-ethylimidazole vapor at temperatures ≤ 100 °C. By translating this method to a chemical vapor deposition (CVD) protocol, mesoporous crystalline films could be deposited for the first time entirely from the vapor phase. A combination of PALS and Kr physisorption measurements confirmed the porosity of these MOF-CVD films and the size of the MAF-6 supercages (diam. ~2 nm), in close agreement with powder data and calculations. MAF-6 powders and films were further characterized by XRD, TGA, SEM, FTIR, PDF and EXAFS. The exceptional uptake capacity of the mesoporous MAF-6 in comparison to the microporous ZIF-8 is demonstrated by vapor-phase loading of a molecule larger than the ZIF-8 windows.

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