Repeated Hepatic Dearterialization for Unresectable Carcinomas of the Liver: Report of a 10-Year Experience

Surgery Today ◽  
2001 ◽  
Vol 31 (11) ◽  
pp. 984-990 ◽  
Author(s):  
Takeo Kimoto ◽  
Akira Yamanoi ◽  
Masaaki Uchida ◽  
Yoshinari Makino ◽  
Takashi Ono ◽  
...  
Keyword(s):  
Hepatic Dearterialization

Changes in liver function after hepatic dearterialization in man

1973 ◽  
Vol 3 (1) ◽  
pp. 40-51 ◽  
Author(s):  
Naofumi Nagasue ◽  
Hirokuni Murakami ◽  
Kinji Ayabe ◽  
Kiichiro Ichimaru ◽  
Sadao Arari ◽  
...  
Keyword(s):  
Liver Function ◽  
Hepatic Dearterialization

Present Experiences with Hepatic Dearterialization in Liver Neoplasm

2015 ◽  
pp. 141-166 ◽  
Author(s):  
S. Bengmark ◽  
P. Fredlund ◽  
L. O. Hafstr�m ◽  
J. Vang
Keyword(s):  
Liver Neoplasm ◽  
Hepatic Dearterialization

Metabolic responses to intermittent hepatic dearterialization in the rat

1991 ◽  
Vol 13 (1) ◽  
pp. 33-37
Author(s):  
Susanne Sjövall ◽  
Bo Ahrén ◽  
Per Hansson ◽  
Steffen Loft ◽  
Henrik E. Poulsen ◽  
...  
Keyword(s):  
Metabolic Responses ◽  
Hepatic Dearterialization

Liver necrosis after hepatic dearterialization in pigs

1985 ◽  
Vol 8 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Hans Stridbeck ◽  
Lars E. Lorelius
Keyword(s):  
Liver Necrosis ◽  
Hepatic Dearterialization

scholarly journals Repeated Hepatic Dearterialization for Unresectable Liver Metastases From Gastric Cancer: Review of Five Cases

HPB Surgery ◽  
1995 ◽  
Vol 8 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Takeo Kimoto ◽  
Naofumi Nagasue ◽  
Hitoshi Kohno ◽  
Yu-Chung Chang ◽  
Hiroyuki Taniura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Hepatic Artery ◽  
Tumour Regression ◽  
Long Survival ◽  
Artery Cannulation ◽  
Cancer Review ◽  
Hepatic Dearterialization ◽  
Multiple Metastases ◽  
Unresectable Liver Metastases

A novel method of repeated hepatic dearterialization was evaluated in five patients with multiple metastases from gastric cancer in both hepatic lobes. After gastrectomy with extensive lymph node dissection (R2/3), all patients underwent implantation of a vascular occluder around the hepatic artery. Cannulation of the hepatic artery was added for later chemotherapy. The hepatic artery was occluded repeatedly for 1 hour twice daily in combination with intrahepatic infusion of anticancer drugs for as long as possible. Three of five patients demonstrated marked tumour regression with unexpectedly long survival (16 months in two patients and one still alive at 15 months). Carcinoembryonic antigen (CEA) levels decreased to almost normal in four patients who had initially high levels. The present experiences seems to indicate that long survival can be hoped for in patients with advanced gastric cancer with unresectable liver metastases.

scholarly journals Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

2016 ◽  
Vol 2016 ◽  
pp. 1-14
Author(s):  
Jun Jiang ◽  
Jishu Wei ◽  
Junli Wu ◽  
Wentao Gao ◽  
Qiang Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Portal Vein ◽  
Acute Liver Injury ◽  
Acute Ischemia ◽  
Sprague Dawley ◽  
Ductular Reaction ◽  
Hepatic Ischemia ◽  
Portal Vein Arterialization ◽  
Transmission Electron ◽  
Hepatic Dearterialization

Hepatic infarcts or abscesses occur after hepatic artery interruption. We explored the mechanisms of hepatic deprivation-induced acute liver injury and determine whether partial portal vein arterialization attenuated this injury in rats. Male Sprague-Dawley rats underwent either complete hepatic arterial deprivation or partial portal vein arterialization, or both. Hepatic ischemia was evaluated using biochemical analysis, light microscopy, and transmission electron microscopy. Hepatic ATP levels, the expression of hypoxia- and inflammation-associated genes and proteins, and the expression of bile transporter genes were assessed. Complete dearterialization of the liver induced acute liver injury, as evidenced by the histological changes, significantly increased serum biochemical markers, decreased ATP content, increased expression of hypoxia- and inflammation-associated genes and proteins, and decreased expression of bile transporter genes. These detrimental changes were extenuated but not fully reversed by partial portal vein arterialization, which also attenuated ductular reaction and fibrosis in completely dearterialized rat livers. Collectively, complete hepatic deprivation causes severe liver injury, including bile infarcts and biloma formation. Partial portal vein arterialization seems to protect against acute ischemia-hypoxia-induced liver injury.

scholarly journals Metastatic Carcinoid to the Liver Treated by Hepatic Dearterialization

1974 ◽  
Vol 180 (3) ◽  
pp. 305-308 ◽  
Author(s):  
WILLIAM V. McDERMOTT ◽  
TERRY W. HENSLE
Keyword(s):  
Metastatic Carcinoid ◽  
Hepatic Dearterialization

Changes in coagulation factors after hepatic dearterialization in man

1968 ◽  
Vol 116 (3) ◽  
pp. 414-418 ◽  
Author(s):  
O. Almersjö ◽  
S. Bengmark ◽  
L.O. Hafström ◽  
K. Korsan-Bengtsen ◽  
J. Ygge
Keyword(s):  
Coagulation Factors ◽  
Hepatic Dearterialization
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