scholarly journals Persistent degenerative changes in the intervertebral disc after burst fracture in an in vitro model mimicking physiological post-traumatic conditions

2014 ◽  
Vol 24 (9) ◽  
pp. 1901-1908 ◽  
Author(s):  
Stefan Dudli ◽  
Daniel Haschtmann ◽  
Stephen John Ferguson
Keyword(s):  
Intervertebral Disc ◽  
In Vitro Model ◽  
Burst Fracture ◽  
Degenerative Changes ◽  
Post Traumatic ◽  
Vitro Model

scholarly journals A new in-vitro model to investigate antibiotic penetration of the intervertebral disc

1995 ◽  
Vol 77-B (6) ◽  
pp. 967-970 ◽  
Author(s):  
W Thomas Rde ◽  
JJ Batten ◽  
S Want ◽  
ID McCarthy ◽  
M Brown ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
In Vitro Model ◽  
Vitro Model

Spinal cord–fragment interactions following burst fracture: an in vitro model

2006 ◽  
Vol 5 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Richard M. Hall ◽  
Robert J. Oakland ◽  
Ruth K. Wilcox ◽  
David C. Barton
Keyword(s):  
Spinal Cord ◽  
High Speed ◽  
In Vitro Model ◽  
Burst Fracture ◽  
Posterior Longitudinal Ligament ◽  
Bone Fragment ◽  
The Status ◽  
Vitro Model ◽  
The Impact

Object The purpose of the study was to develop an in vitro model of the bone fragment and spinal cord interactions that occur during a burst fracture and further the understanding of how the velocity of the bone fragment and the status of the posterior longitudinal ligament (PLL) affect the deformation of the cord. Methods An in vitro model was developed such that high-speed video and pressure measurements recorded the impact of a simulated bone fragment on sections of explanted bovine spinal cord. The model simulated the PLL and the posterior elements. The status of the PLL had a significant effect on both the maximum occlusion of the spinal cord and the time for occlusion to occur. Raising the fragment velocity led to an overall increase in the spinal cord deformation. Interestingly the dura mater appeared to have little or no effect on the extent of occlusion. Conclusions These findings may indicate the importance of the dura’s interaction with the cerebrospinal fluid in protecting the cord during this type of impact.

INTERVERTEBRAL DISC DEGENERATION TRIGGERED BY TRAUMATIC IMPACT LOADING: AN IN VITRO MODEL

2008 ◽  
Vol 41 ◽  
pp. S258
Author(s):  
Daniel Haschtmann ◽  
Jivko V. Stoyanov ◽  
Philippe Gédet ◽  
Stephen J. Ferguson
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Impact Loading ◽  
Intervertebral Disc Degeneration ◽  
In Vitro Model ◽  
Vitro Model ◽  
Traumatic Impact

In Vitro Model System to Study Mouse Intervertebral Disc Growth

2010 ◽  
Vol 10 (9) ◽  
pp. S138
Author(s):  
Chitra Dahia ◽  
Eric Mahoney ◽  
Eric Wall ◽  
Christopher Wylie
Keyword(s):  
Intervertebral Disc ◽  
In Vitro Model ◽  
Model System ◽  
In Vitro Model System ◽  
Vitro Model

scholarly journals Flow-Related Mechanics of the Intervertebral Disc: The Validity of an In Vitro Model

Spine ◽  
2005 ◽  
Vol 30 (18) ◽  
pp. E534-E539 ◽  
Author(s):  
Albert J. van der Veen ◽  
Margriet Mullender ◽  
Theo H. Smit ◽  
Idsart Kingma ◽  
Jaap H. van Dieën
Keyword(s):  
Intervertebral Disc ◽  
In Vitro Model ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

A new in vitro model for pre-transplantation diagnosis of frozen/thawed human ovarian tissue

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
M Salama ◽  
K Winkler ◽  
KF Murach ◽  
S Hofer ◽  
L Wildt ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Ovarian Tissue ◽  
Human Ovarian Tissue ◽  
Vitro Model
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