Primary small cell carcinoma of the esophagus with achalasia in a patient in whom pro-gastrin-releasing peptide and neuron-specific enolase levels reflected the clinical course during chemotherapy

1999 ◽  
Vol 34 (3) ◽  
pp. 378-382 ◽  
Author(s):  
Hiroyuki Suzuki ◽  
Shigekazu Takayanagi ◽  
Takayasu Otake ◽  
Ruri Ishibashi ◽  
Satoshi Osawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Clinical Course ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Gastrin Releasing Peptide

Serum Neuron-Specific Enolase as a Marker of Small-Cell Carcinoma of the Esophagus

1990 ◽  
Vol 12 (4) ◽  
pp. 384-388 ◽  
Author(s):  
Koji Sasajima ◽  
Manabu Watanabe ◽  
Toshiaki Ando ◽  
Kunihiko Hao ◽  
Masao Miyashita ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Serum Neuron Specific Enolase

scholarly journals Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Renda Li ◽  
Zhenlin Yang ◽  
Fei Shao ◽  
Hong Cheng ◽  
Yaru Wen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Molecular Subtypes ◽  
Clinical Course ◽  
Expression Patterns ◽  
Neuroendocrine Differentiation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Carcinoma Of The Esophagus ◽  
Whole Exome

AbstractPrimary small cell carcinoma of the esophagus (PSCCE) is a lethal neuroendocrine carcinoma. Previous studies proposed a genetic similarity between PSCCE and esophageal squamous cell carcinoma (ESCC) but provided little evidence for differences in clinical course and neuroendocrine differentiation. We perform whole-exome sequencing, RNA sequencing and immunohistochemistry profiling on 46 PSCCE cases. Integrated analyses enable the discovery of multiple mechanisms of RB1 disruption in 98% (45/46) of cases. The transcriptomic landscape of PSCCE closely resembles small cell lung cancer (SCLC) but differs from ESCC or esophageal adenocarcinoma (EAC). Distinct gene expression patterns regulated by ASCL1 and NEUROD1 define two molecular subtypes, PSCCE-A and PSCCE-N, which are highly similar to SCLC subtypes. A T cell excluded phenotype is widely observed in PSCCE. In conclusion, PSCCE has genomic alterations, transcriptome features and molecular subtyping highly similar to SCLC but distinct from ESCC or EAC. These observations are relevant to oncogenesis mechanisms and therapeutic vulnerability.

scholarly journals MET-04 A case of Brain Metastases with repeated bleeding from Esophageal carcinoma

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii19-ii19
Author(s):  
Masataka Mikai ◽  
Mitsuyoshi Abe ◽  
Yo watanabe ◽  
Chie Nakada ◽  
Yutaka Huchinoue ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Metastases ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Cerebral Hemorrhage ◽  
Small Cell ◽  
The Body ◽  
Metastatic Brain Tumor ◽  
Carcinoma Of The Esophagus

Abstract Brain metastases from esophageal cancer is rare and the incidence has been reported at approximately 5%. We report a case of brain metastases with repeated bleeding from Esophageal carcinoma. The case is a 76-year-old man. Three years ago he was diagnosed with small cell carcinoma of the esophagus by endoscopic biopsy. Metastasis was found only in the cervical lymph node, but the condition was stable by chemoradiotherapy and no metastases were found throughout the body before 1 month. He was admitted to the hospital because of a sudden convulsion, and CT scan revealed cerebral hemorrhage in the right frontal lobe. We performed conservative treatment, but rebleeding was observed from the same site repeatedly after 1 month and 2 months. Due to the influence of bleeding, it was difficult to distinguish cerebral hemorrhage from brain tumor by contrast MRI. After surgery, the cause of bleeding was diagnosed as metastatic brain tumor of esophageal small cell carcinoma. Postoperative radiation therapy was performed in another hospital, but rebleeding was observed 3 months after the operation. A reoperation was performed at another hospital, and a recurrence of metastatic brain tumor was diagnosed. In the case of highly malignant metastatic brain tumors, it was considered necessary to frequently follow the images.

Role of surgery in the management and prognosis of limited-stage small cell carcinoma of the esophagus

2014 ◽  
Vol 28 (5) ◽  
pp. 476-482 ◽  
Author(s):  
M. R. Xie ◽  
S. B. Xu ◽  
X. H. Sun ◽  
L. Ke ◽  
X. Y. Mei ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Limited Stage

scholarly journals A Rare Cause of the Cough: Primary Small Cell Carcinoma of Esophagus—Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Erdal Yekeler ◽  
Timur Koca ◽  
Semra Vural
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Histopathological Examination ◽  
Hepatic Metastases ◽  
Endoscopic Examination ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Carcinoma Of Esophagus ◽  
Chest X Ray ◽  
Rare Malignancy

Primary small cell carcinoma of the esophagus is a relatively rare malignancy. It is highly progressive and poorly prognostic in untreated conditions. In the western populations, the rate of primary small cell carcinoma in all esophageal cancer types is between 0.05% and 2.4%, while it is endemically increasing up to 7.6% in the eastern populations. Most of the cases are in extensive stage at the time of diagnosis. Surgery is the treatment of choice in limited stages, but treatment must be multimodal in primary small cell carcinoma of the esophagus. A 47-year-old woman was referred to our clinic with gradually increasing severe dry cough and slight difficulty in swallowing for 20 days. Chest X-ray graphy was normal, and computed tomography of the chest showed multiple mediastinal lymph nodes and hepatic metastases. Her endoscopic examination revealed an endoluminal vegetative mass between 20 cm and 23 cm of her esophagus. The case was reported as small cell carcinoma of the esophagus on histopathological examination. The case was assumed inoperable, and chemotherapy and radiotherapy were planned. We presented a rare cause of the cough and primary esophageal small cell carcinoma in this paper.

scholarly journals Primary small cell carcinoma of the esophagus: Comparison between a Chinese cohort and Surveillance, Epidemiology, and End Results (SEER) data

2019 ◽  
Vol 8 (3) ◽  
pp. 1074-1085 ◽  
Author(s):  
Qin Xiao ◽  
Haifan Xiao ◽  
Shuyu Ouyang ◽  
Jinming Tang ◽  
Baihua Zhang ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Esophagus ◽  
Seer Data ◽  
Chinese Cohort ◽  
End Results
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