Age-related nephropathy in the Fischer 344 rat is associated with overexpression of collagens and collagen-binding heat shock protein 47

1998 ◽  
Vol 293 (3) ◽  
pp. 471-478 ◽  
Author(s):  
M. S. Razzaque ◽  
I. Shimokawa ◽  
A. Nazneen ◽  
Y. Higami ◽  
T. Taguchi
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Collagen Binding ◽  
Heat Shock Protein 47 ◽  
Fischer 344 ◽  
Age Related ◽  
Fischer 344 Rat

scholarly journals Involvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis

2015 ◽  
Vol 6 (8) ◽  
pp. 589-598 ◽  
Author(s):  
Haiyan Chu ◽  
Ting Wu ◽  
Wenyu Wu ◽  
Wenzhen Tu ◽  
Shuai Jiang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Collagen Binding ◽  
Heat Shock Protein 47

Fibrogenic role of Collagen-Binding Heat Shock Protein 47 in Lacrimal Glands of Patients with Chronic Graft versus Host Disease

2005 ◽  
Vol 3 ◽  
pp. S98
Author(s):  
Yoko Ogawa ◽  
Mohammed S. Razzaque ◽  
Masataka Kawai ◽  
Kaori Kameyama ◽  
Yukihiko Mashima ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Graft Versus Host Disease ◽  
Lacrimal Glands ◽  
Collagen Binding ◽  
Host Disease ◽  
Heat Shock Protein 47 ◽  
Graft Versus Host

Age-related alteration of proline hydroxylase and collagen-binding heat shock protein (HSP47) expression in human fibroblasts

1995 ◽  
Vol 85 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Osamu Miyaishi ◽  
Ken-ichi Kozaki ◽  
Shinsuke Saga ◽  
Tsuneko Sato ◽  
Yoshio Hashizume
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Human Fibroblasts ◽  
Collagen Binding ◽  
Age Related ◽  
Proline Hydroxylase

Role of Heat Shock Protein 47, a Collagen-Binding Chaperone, in Lacrimal Gland Pathology in Patients with cGVHD

2007 ◽  
Vol 48 (3) ◽  
pp. 1079 ◽  
Author(s):  
Yoko Ogawa ◽  
Mohammed S. Razzaque ◽  
Kaori Kameyama ◽  
Go Hasegawa ◽  
Shigeto Shimmura ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Lacrimal Gland ◽  
Collagen Binding ◽  
Heat Shock Protein 47

Increased expression of collagen-binding heat shock protein 47 in murine bleomycin-induced pneumopathy

2003 ◽  
Vol 285 (4) ◽  
pp. L957-L963 ◽  
Author(s):  
Hiroshi Ishii ◽  
Hiroshi Mukae ◽  
Tomoyuki Kakugawa ◽  
Tetsuji Iwashita ◽  
Hideyuki Kaida ◽  
...  
Keyword(s):  
Heat Shock ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Smooth Muscle Actin ◽  
Protein A ◽  
Immunohistochemical Analysis ◽  
Rt Pcr ◽  
Heat Shock Protein 47 ◽  
Positive Type ◽  
Fibrotic Process

The 47-kDa heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role during the processing and/or secretion of procollagen. Expression of HSP47 has been reported to increase in parallel with expression of collagens during the progression of various fibrosis models. The aim of the present study was to investigate the association between HSP47 expression and collagen accumulation in bleomycin (BLM)-induced murine fibrosis. We investigated the expression of HSP47 protein and mRNA using immunohistochemical analysis and semi-quantitative RT-PCR in murine BLM-induced pulmonary fibrosis. Immunohistochemical analysis showed that higher expression of HSP47 protein was present in BLM-induced pulmonary fibrosis compared with controls. HSP47 was localized predominantly in α-smooth muscle actin-positive myofibroblasts, F4/80 negative, surfactant protein-A-positive type II pneumocytes, and F4/80-positive macrophages. RT-PCR also demonstrated an increase of HSP47 mRNA expression in BLM-treated lungs. Moreover, the relative amounts of HSP47 mRNA correlated significantly with the lung hydroxyproline content as an indicator of pulmonary fibrosis in BLM-treated lungs ( r = 0.406, P <0.05). Our results suggest that these cells may play a role in the fibrotic process of BLM-treated lungs through upregulation of HSP47.

Sign in / Sign up

Export Citation Format

Share Document