Ultrastructural characterization of interstitial cells of Cajal in the rat small intestine using control and Ws/Ws mutant rats

1998 ◽  
Vol 293 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Kazuhide Horiguchi ◽  
T. Komuro
Keyword(s):  
Small Intestine ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Rat Small Intestine ◽  
Ultrastructural Characterization ◽  
Cells Of Cajal

scholarly journals Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine

2018 ◽  
Vol 54 (1) ◽  
pp. 63
Author(s):  
Il Koo Park ◽  
Jin Ho Kim ◽  
Chan Guk Park ◽  
Man Yoo Kim ◽  
Shankar Prasad Parajuli ◽  
...  
Keyword(s):  
Small Intestine ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Activity ◽  
Mouse Small Intestine ◽  
Cells Of Cajal

Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease

2002 ◽  
Vol 97 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Christophe Porcher ◽  
Marjolaine Baldo ◽  
Monique Henry ◽  
Pierre Orsoni ◽  
Yvon Jule ◽  
...  
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Cells Of Cajal

Action potential generation in the small intestine of W mutant mice that lack interstitial cells of Cajal

1996 ◽  
Vol 271 (3) ◽  
pp. G387-G399 ◽  
Author(s):  
J. Malysz ◽  
L. Thuneberg ◽  
H. B. Mikkelsen ◽  
J. D. Huizinga
Keyword(s):  
Small Intestine ◽  
Action Potentials ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
K Channel ◽  
Pacemaker Activity ◽  
Channel Blockade ◽  
Auerbach’S Plexus ◽  
Cells Of Cajal ◽  
Auerbach's Plexus

The small intestine of W/Wv mice lacks both the network of interstitial cells of Cajal (ICC), associated with Auerbach's plexus, and pacemaker activity, i.e., it does not generate slow-wave-type action potentials. The W/Wv muscle preparations showed a wide variety of electrical activities, ranging from total quiescence to generation of action potentials at regular or irregular frequency with or without periods of quiescence. The action potentials consisted of a slow component with superimposed spikes, preceded by a slowly developing depolarization and followed by a transient hyperpolarization. The action potentials were completely abolished by L-type Ca2+ channel blockers. W/Wv mice responded to K+ channel blockade (0.5 mM Ba2+ or 10 mM tetraethylammonium chloride) with effects on amplitude, frequency, rate of rise, and duration of the action potentials. In quiescent tissues from W/Wv mice, K+ channel blockade evoked the typical spikelike action potentials. Electron microscopy identified few methylene blue-positive cells in the W/Wv small intestine associated with Auerbach's plexus as individual ICC. Numbers of resident macrophage-like cells (MLC) and fibroblast-like cells (FLC) were significantly changed. Neither FLC nor MLC were part of a network nor did they form specialized junctions with neighboring cells as ICC do. Hence no cell type had replaced ICC at their normal morphological position associated with Auerbach's plexus. ICC were present in W/Wv mice at the deep muscular plexus in normal organization and numbers, indicating that they are not dependent on the Kit protein and do not take part in generation of pacemaker activity.

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