Expression of vascular endothelial growth factor by granulated metrial gland cells in pregnant murine uteri

2000 ◽  
Vol 300 (2) ◽  
pp. 285-293 ◽  
Author(s):  
Sachio Ogita ◽  
Kenji Kaneda ◽  
Chunlian Wang ◽  
Hiroaki Nakamura ◽  
Naohiko Umesaki ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Gland Cells ◽  
Granulated Metrial Gland Cells ◽  
Metrial Gland ◽  
Endothelial Growth Factor

HUMAN LACTIFEROUS MAMMARY GLAND CELLS PRODUCE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND EXPRESS THE VEGF RECEPTORS, Flt-1 AND KDR/Flk-1

Cytokine ◽  
2002 ◽  
Vol 18 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Shoko Nishimura ◽  
Nobuaki Maeno ◽  
Katsuhiko Matsuo ◽  
Toshihiro Nakajima ◽  
Isao Kitajima ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Mammary Gland ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Vegf Receptors ◽  
Gland Cells ◽  
Mammary Gland Cells ◽  
Endothelial Growth Factor

Vascular endothelial growth factor production by rat granulated metrial gland cells and their morphological features in normal and pathological conditions

2007 ◽  
Vol 19 (2) ◽  
pp. 341 ◽  
Author(s):  
Celal Kaloglu ◽  
H. Eray Bulut
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Blood Vessels ◽  
Cell Structure ◽  
Vascular Endothelial ◽  
Intense Staining ◽  
Pathological Conditions ◽  
Metrial Gland ◽  
Implantation Sites ◽  
Endothelial Growth Factor

Granulated metrial gland (GMG) cells are pregnancy-specific cells that may have many functions in successful placentation and pregnancy. In the present study, changes in the rat GMG cell structure, distribution and vascular endothelial growth factor (VEGF) expression during early pregnancy were evaluated by light microscopy. Implantation sites taken from females with spontaneous abortion were also investigated. On Day 7 of pregnancy, GMG cells were distributed through the implantation and interimplantation sites. They formed metrial glands in the mesometrial triangle on Day 9, and were observed in the decidua basalis on Day 14 of pregnancy. Avidin–biotin complex immunohistochemistry revealed that GMG cells showed moderate staining for VEGF at the beginning of pregnancy and intense staining on Days 9 and 10 of pregnancy. They were localised mostly near the newly formed blood vessels. The implantation sites from spontaneously aborting females showed numerous leucocytes in the lumen of mesometrial blood vessels. In spontaneously aborting females, GMG cells showed a distinct morphology, increased in number and volume, their granules were denser and degranulation was observed. These results suggest that rat GMG cells might be a guide for placental angiogenesis and they might share a role with leucocytes in pathological conditions.

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