Antenatal screening and fetal diagnosis of β-thalassemia in a Chinese population: prevalence of the β-thalassemia trait in the Guangzhou area of China

1996 ◽  
Vol 98 (2) ◽  
pp. 199-202 ◽  
Author(s):  
X. Xu ◽  
C. Liao ◽  
Zhongying Liu ◽  
Yining Huang ◽  
Jizeng Zhang ◽  
...  
Gerontology ◽  
1995 ◽  
Vol 41 (2) ◽  
pp. 98-108 ◽  
Author(s):  
J. Woo ◽  
S.C. Ho ◽  
Y.K. Yuen ◽  
J. Lau

Author(s):  
Sabeen Khan ◽  
Sahira Aaraj ◽  
Syeda Namayah Fatima Hussain

Abstract Objective: To study the frequency and types of haemoglobinopathies in children with microcytic anaemia. Method: The prospective study was conducted at the Paediatric Out-patient Department of Shifa Falahi Community Health Centre, Islamabad, Pakistan, from July to December, 2018, and comprised patients aged from 3 months to 14 years who had haemoglobin <10mg/dl and mean corpuscular volume <70fL. Serum ferritin and haemoglobin electrophoresis were done to check for iron deficiency anemia and haemoglobinopathies. Data was analysed using SPSS 23. Results: Of 175 subjects, 33(18.9%) had haemoglobinopathies and 142(81.1%) had iron deficiency anaemia. Thalassemia trait 18(10.3%) was the leading cause amongst haemoglobinopathies, followed by thalassemia major 8(4.6 %) and intermedia 5(2.9%). There were 2(1.1%) patients with haemoglobin D. Conclusion: The prevalence of hemoglobinopathies was high. Identification of haemoglobinopathies is important for proper treatment, antenatal screening and future genetic counselling. Key Words: Haemoglobinopathy, Iron deficiency anaemia, Microcytic, MCV, IDA.


PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e30937 ◽  
Author(s):  
Xiang Yang Zhang ◽  
Jun Liang ◽  
Da Chun Chen ◽  
Mei Hong Xiu ◽  
Jincai He ◽  
...  

2020 ◽  
Vol 37 (8) ◽  
pp. 812-821
Author(s):  
Yanmei Shen ◽  
Fanchao Meng ◽  
Huiming Xu ◽  
Xia Li ◽  
Yaru Zhang ◽  
...  

2015 ◽  
Vol 8 (4) ◽  
pp. 184-189 ◽  
Author(s):  
Orly Lavee ◽  
Giselle Kidson-Gerber

Background Antenatal screening can predict clinically significant haemoglobinopathies, however in Australia, practices are not standardised and are evolving as the population becomes more ethnically diverse. This study describes antenatal screening practices in a large Australian laboratory/antenatal service. Methods Data were collected retrospectively on consecutive antenatal haemoglobin electrophoresis over 16 months and correlated with obstetric data, obtained from the local obstetric database. Results 462 patients were included, with an average gestation of 25.8 weeks. ‘Pregnancy’ was the most common stated indication, with absent indication/clinical information in 8%. Gestational age was documented in 54%. In 15%, no contact details of the referrer were documented and partner screening was traceable in only 25 cases (5.4%). In 82% of cases, no abnormalities were detected. Beta thalassemia trait was the most common positive result. Only 52% of patients had recent iron studies. The mean haemoglobin was 111.6 g/L and mean cell volume was 80.5 fl at the time of testing. Ethnicity was documented on the request form in 3%. After Australasia, the most common ethnicity of patients was South East Asia and the Middle East. Conclusion Referral patterns in our health service are diverse and reflect our changing population and care practices. Detailed guidelines are required and we propose a comprehensive algorithm for general use where selective screening is practiced within an Australasian population or one with similar demographics.


Author(s):  
Keyi Zhang ◽  
Zhenzhen Su ◽  
Jing Hu ◽  
Zhuochun Huang ◽  
Chaojun Hu ◽  
...  

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