Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy

2000 ◽  
Vol 107 (5) ◽  
pp. 440-451 ◽  
Author(s):  
Takuro Arimura ◽  
Takeyuki Nakamura ◽  
Shitoshi Hiroi ◽  
Manatsu Satoh ◽  
Megumi Takahashi ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Actin Binding ◽  
Binding Motif

Primary prevention of sudden death in idiopathic dilated cardiomyopathy

ESC CardioMed ◽  
2018 ◽  
pp. 2341-2345
Author(s):  
Riccardo Cappato
Keyword(s):  
Primary Prevention ◽  
Sudden Death ◽  
Dilated Cardiomyopathy ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Conduction Delay ◽  
Icd Therapy ◽  
Fatal Arrhythmia ◽  
Life Threatening

In patients with dilated cardiomyopathy, the mechanisms of life-threatening arrhythmias are likely determined by subendocardial scarring, electrolyte unbalance, stretch-induced electrophysiological changes, autonomic impairment, conduction delay, or proarrhythmic effects of drug therapy. Sudden death may occur as a consequence of ventricular fibrillation, but electromechanical dissociation or bradycardia may also be a possible underlying cause. Most of the clinical characterization of idiopathic dilated cardiomyopathy is drawn from studies also enrolling patients with cardiomyopathies secondary to recognizable underlying conditions. Secular trends have improved the ability of early diagnosis, and the therapeutic strategies used to prevent sudden death. The role of implantable cardioverter defibrillator (ICD) therapy for the primary prevention of all-cause mortality is controversial with some studies showing and others questioning the benefit of ICD in this population. revious randomized studies conducted in large heterogeneous populations showed that ICD therapy is beneficial and improves survival by about 30%. This therapy is currently recommended for all survivors of a near-fatal arrhythmia regardless of the underlying substrate.

Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated Cardiomyopathy

1999 ◽  
Vol 31 (5) ◽  
pp. 1025-1032 ◽  
Author(s):  
Frédérique Tesson ◽  
Philippe Charron ◽  
Mireille Peuchmaurd ◽  
Viviane Nicaud ◽  
François Cambien ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Genetic Variant ◽  
Idiopathic Dilated Cardiomyopathy

scholarly journals Identification and Characterization of the Actin-Binding Motif of Phostensin

2012 ◽  
Vol 13 (12) ◽  
pp. 15967-15982 ◽  
Author(s):  
Tzu-Fan Wang ◽  
Ning-Sheng Lai ◽  
Kuang-Yung Huang ◽  
Hsien-Lu Huang ◽  
Ming-Chi Lu ◽  
...  
Keyword(s):  
Actin Binding ◽  
Binding Motif ◽  
Identification And Characterization
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