Magnetic resonance images of 91 children with different causes of short stature: pituitary size reflects growth hormone secretion

1997 ◽  
Vol 156 (10) ◽  
pp. 758-763 ◽  
Author(s):  
B. H. P. Nagel ◽  
M. Palmbach ◽  
D. Petersen ◽  
M. B. Ranke
Keyword(s):  
Growth Hormone ◽  
Magnetic Resonance ◽  
Short Stature ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Magnetic Resonance Images

Pituitary volume in children with growth hormone deficiency, idiopathic short stature and controls

2016 ◽  
Vol 29 (10) ◽  
Author(s):  
Marion Kessler ◽  
Michael Tenner ◽  
Michael Frey ◽  
Richard Noto
Keyword(s):  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Short Stature ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Magnetic Resonance Images ◽  
Idiopathic Short Stature ◽  
Hormone Deficiency ◽  
Significant Difference

AbstractBackground:The objective of the study was to describe the pituitary volume (PV) in pediatric patients with isolated growth hormone deficiency (IGHD), idiopathic short stature (ISS) and normal controls.Methods:Sixty-nine patients (57 male, 12 female), with a mean age of 11.9 (±2.0), were determined to have IGHD. ISS was identified in 29 patients (20 male, 9 female), with a mean age of 12.7 (±3.7). Sixty-six controls (28 female, 38 male), mean age 9.8 (±4.7) were also included. Three-dimensional (3D) magnetic resonance images with contrast were obtained to accurately measure PV.Results:There was a significant difference in the mean PV among the three groups. The IGHD patients had a mean PV 230.8 (±89.6), for ISS patients it was 286.8 (±108.2) and for controls it was 343.7 (±145.9) (p<0.001). There was a normal increase in PV with age in the ISS patients and controls, but a minimal increase in the IGHD patients.Conclusions:Those patients with isolated GHD have the greatest reduction in PV compared to controls and the patients with ISS fall in between. We speculate that a possible cause for the slowed growth in some ISS patients might be related to diminished chronic secretion of growth hormone over time, albeit having adequate pituitary reserves to respond acutely to GH stimulation. Thus, what was called neurosecretory GHD in the past, might, in some patients, be relative pituitary hypoplasia and resultant diminished growth hormone secretion. Thus, PV determinations by magnetic resonance imaging (MRI) could assist in the diagnostic evaluation of the slowly growing child.

Standard and low-dose IGF-I generation tests and spontaneous growth hormone secretion in children with idiopathic short stature

2004 ◽  
Vol 60 (2) ◽  
pp. 163-168 ◽  
Author(s):  
J. C. Blair ◽  
C. Camacho-Hübner ◽  
F. Miraki Moud ◽  
S. Rosberg ◽  
C. Burren ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Low Dose ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Idiopathic Short Stature ◽  
Spontaneous Growth ◽  
Igf I

scholarly journals Understanding Growth Hormone Secretion and Short Stature

2016 ◽  
Vol 06 (01) ◽  
pp. 78-86
Author(s):  
Milton Rodrigo Lafuente Covarrubias ◽  
Luis Fernando de Azevedo Piovezani ◽  
Frederico Martins Cordeiro ◽  
William Cabrera Viana ◽  
Mirella Hansen de Almeida ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Hormone Secretion ◽  
Growth Hormone Secretion

Human Growth Hormone Secretion after Exercise and Oral Glucose Administration in Patients with Short Stature

1972 ◽  
Vol 34 (6) ◽  
pp. 1055-1058 ◽  
Author(s):  
YOSHIAKI OKADA ◽  
TORU HIKITA ◽  
KAZUYUKI ISHITOBI ◽  
MASAYOSHI WADA ◽  
YASUNOBU SANTO ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Human Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Human Growth ◽  
Oral Glucose ◽  
Glucose Administration
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