Resistance to Trypanosoma cruzi infection in mice does not necessarily correlate with production of interferon- g in vivo

1998 ◽  
Vol 187 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Christian Meyer zum Büschenfelde ◽  
Sven Cramer ◽  
B. Fleischer ◽  
Stefanie Frosch
Keyword(s):  
Trypanosoma Cruzi ◽  
Cruzi Infection

scholarly journals Benznidazole Treatment following Acute Trypanosoma cruzi Infection Triggers CD8+ T-Cell Expansion and Promotes Resistance to Reinfection

2002 ◽  
Vol 46 (12) ◽  
pp. 3790-3796 ◽  
Author(s):  
Bianca Perdigão Olivieri ◽  
Vinícius Cotta-de-Almeida ◽  
Tania Araújo-Jorge
Keyword(s):  
T Lymphocytes ◽  
Trypanosoma Cruzi ◽  
Immune Regulation ◽  
Immune Dysregulation ◽  
Direct Role ◽  
Parasite Replication ◽  
The Impact ◽  
Shed Light ◽  
Cruzi Infection

ABSTRACT Many studies have shed light on the mechanisms underlying both immunoprotection and immune dysregulation arising after Trypanosoma cruzi infection. However, little is known about the impact of benznidazole (N-benzyl-2-nitroimidazole acetamide), the drug available for clinical treatment of the infection, on the immune system in the infected host. In the present study we investigated the effect of benznidazole therapy on the lymphoid compartment during the course of experimental T. cruzi infection. Although amelioration of a variety of clinical and parasitological signs was observed in treated mice, amelioration of splenocyte expansion was not detected. Interestingly, this sustained splenomegaly observed in benznidazole-treated mice showed a preferential expansion of CD8+ T lymphocytes. Moreover, although benznidazole treatment blocked the expansion of recently activated CD4+ and CD8+ T cells seen in infected hosts, benznidazole treatment led to a selective expansion of effector and memory CD8+ T lymphocytes in association with a lower rate of apoptosis. In addition, the surviving treated animals were protected from reinfection. Together, these data suggest that, in addition to its well-known direct role in blocking parasite replication in vivo, benznidazole appears to directly affect immune regulation in T. cruzi-infected hosts.

scholarly journals A Parent-of-Origin Effect Determines the Susceptibility of a Non-Informative F1 Population to Trypanosoma cruzi Infection In Vivo

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56347 ◽  
Author(s):  
Grace K. Silva ◽  
Larissa D. Cunha ◽  
Catarina V. Horta ◽  
Alexandre L. N. Silva ◽  
Fredy R. S. Gutierrez ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Parent Of Origin ◽  
Origin Effect ◽  
Cruzi Infection

New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations

2018 ◽  
Vol 92 (3) ◽  
pp. 1670-1682 ◽  
Author(s):  
Débora Inácio Leite ◽  
Fábio de Vasconcellos Fontes ◽  
Monica Macedo Bastos ◽  
Lucas Villas Boas Hoelz ◽  
Maria da Conceição Avelino Dias Bianco ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Cruzi Infection

In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models

Acta Tropica ◽  
2020 ◽  
Vol 211 ◽  
pp. 105606
Author(s):  
Julián Ernesto Nicolás Gulin ◽  
Mackenzie Anne Eagleson ◽  
Rodrigo A. López-Muñoz ◽  
María Elisa Solana ◽  
Jaime Altcheh ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Infection Models ◽  
Cruzi Infection

Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy

2017 ◽  
Vol 145 ◽  
pp. 46-53 ◽  
Author(s):  
M.R. Simões-Silva ◽  
J.S. De Araújo ◽  
G.M. Oliveira ◽  
K.C. Demarque ◽  
R.B. Peres ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Combined Therapy ◽  
Drug Repurposing ◽  
Cruzi Infection ◽  
In Vivo Assessment

In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection

2013 ◽  
Vol 134 (4) ◽  
pp. 455-459 ◽  
Author(s):  
Daniele da Silva Ferreira ◽  
Viviane Rodrigues Esperandim ◽  
Miriam Paula Alonso Toldo ◽  
Christian Collins Kuehn ◽  
José Clóvis do Prado Júnior ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Acute Phase ◽  
Cruzi Infection

scholarly journals P100W4-2 Analysis of host cell apoptosis in vitro and in vivo by Trypanosoma cruzi infection

2001 ◽  
Vol 52 (Supplement) ◽  
pp. 102
Author(s):  
Junko SHIMADA ◽  
Chunbin ZOU ◽  
Takeshi NARA ◽  
Miriam PONSTAN ◽  
Takashi AOKI ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Cell Apoptosis ◽  
Host Cell Apoptosis ◽  
Cruzi Infection

Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models

2003 ◽  
Vol 314 (2) ◽  
pp. 223-235 ◽  
Author(s):  
E. M. de Souza ◽  
T. C. Araújo-Jorge ◽  
C. Bailly ◽  
A. Lansiaux ◽  
M. M. Batista ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
In Vivo Models ◽  
Cruzi Infection
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