New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations

2018 ◽  
Vol 92 (3) ◽  
pp. 1670-1682 ◽  
Author(s):  
Débora Inácio Leite ◽  
Fábio de Vasconcellos Fontes ◽  
Monica Macedo Bastos ◽  
Lucas Villas Boas Hoelz ◽  
Maria da Conceição Avelino Dias Bianco ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Cruzi Infection

In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models

Acta Tropica ◽  
2020 ◽  
Vol 211 ◽  
pp. 105606
Author(s):  
Julián Ernesto Nicolás Gulin ◽  
Mackenzie Anne Eagleson ◽  
Rodrigo A. López-Muñoz ◽  
María Elisa Solana ◽  
Jaime Altcheh ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Infection Models ◽  
Cruzi Infection

Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy

2017 ◽  
Vol 145 ◽  
pp. 46-53 ◽  
Author(s):  
M.R. Simões-Silva ◽  
J.S. De Araújo ◽  
G.M. Oliveira ◽  
K.C. Demarque ◽  
R.B. Peres ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Combined Therapy ◽  
Drug Repurposing ◽  
Cruzi Infection ◽  
In Vivo Assessment

scholarly journals P100W4-2 Analysis of host cell apoptosis in vitro and in vivo by Trypanosoma cruzi infection

2001 ◽  
Vol 52 (Supplement) ◽  
pp. 102
Author(s):  
Junko SHIMADA ◽  
Chunbin ZOU ◽  
Takeshi NARA ◽  
Miriam PONSTAN ◽  
Takashi AOKI ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Host Cell ◽  
Cell Apoptosis ◽  
Host Cell Apoptosis ◽  
Cruzi Infection

Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models

2003 ◽  
Vol 314 (2) ◽  
pp. 223-235 ◽  
Author(s):  
E. M. de Souza ◽  
T. C. Araújo-Jorge ◽  
C. Bailly ◽  
A. Lansiaux ◽  
M. M. Batista ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
In Vivo Models ◽  
Cruzi Infection

scholarly journals Arthrospira maxima Paradoxical Effect on Trypanosoma cruzi-Infection

2020 ◽  
Author(s):  
Oscar A REBOREDA-HERNANDEZ ◽  
Adriana L. JUAREZ-SERRANO ◽  
Ivan GARCIA-LUNA ◽  
Nora L RIVERO-RAMIREZ ◽  
Rocio ORTIZ-BUTRON ◽  
...  
Keyword(s):  
Biological Sciences ◽  
Trypanosoma Cruzi ◽  
Early Death ◽  
Parasitic Infections ◽  
Paradoxical Effect ◽  
Macrophage Phagocytosis ◽  
Arthrospira Maxima ◽  
Cruzi Infection

Background: There are only two anti-trypanocidal drugs available, both have a lot of side effects. This is the pioneer study designed to evaluate the Arthrospira maxima effect in Trypanosoma cruzi -infected mice and macrophages. effect in Trypanosoma cruzi -infected mice and macrophages. Methods: A. maxima was administered in vivo, and in vitro (120µL/mL; 200 µL/mL; 500 µL/mL; 852 µL/mL) as prophylaxis, and treatment. In vitro, phagocytosis and viability were measured in macrophages cultures supplemented with A. maxima, and T. cruzi-infected. In vivo A. maxima was supplemented to T. cruziinfected mice in order to obtain the parasitemia curves, parasite amount, and histopathologic changes. This assay was performed in Biological Sciences National School of National Polytechnic Institute, Mexico City, in 2019. Results: In vivo, A. maxima administration exacerbates the immune innate host´s response, followed by mice early death. In vitro, A. maxima supplementation promote T. cruzi- macrophage phagocytosis, but also a sooner T. cruzi- infected macrophage death. Conclusion: A. maxima administration overactive the immune system, decreasing the parasitemia, but causing a severe tissue damage. Then, this nutraceutical has a paradoxical effect on intracellular parasitic infections such as Chagas disease.

scholarly journals Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro

2008 ◽  
Vol 41 (9) ◽  
pp. 796-803 ◽  
Author(s):  
K. Peraza-Cruces ◽  
L. Gutiérrez-Guédez ◽  
D. Castañeda Perozo ◽  
C.R. Lankford ◽  
C. Rodríguez-Bonfante ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Cruzi Infection

scholarly journals In Vitro, In Vivo, and In Silico Studies of Cumanin Diacetate as a Potential Drug against Trypanosoma cruzi Infection

ACS Omega ◽  
2021 ◽  
Author(s):  
Andrés Sánchez Alberti ◽  
María F. Beer ◽  
Natacha Cerny ◽  
Augusto E. Bivona ◽  
Lucas Fabian ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
In Silico ◽  
Potential Drug ◽  
In Silico Studies ◽  
Cruzi Infection

In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach

2018 ◽  
Vol 189 ◽  
pp. 19-27 ◽  
Author(s):  
Mariana Strauss ◽  
Jean Henrique S. Rodrigues ◽  
María Silvina Lo Presti ◽  
Paola Carolina Bazán ◽  
Alejandra Lidia Báez ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Drug Combination ◽  
Multivariate Approach ◽  
Cruzi Infection

scholarly journals In Vitro and In Vivo Investigation of the Efficacy of Arylimidamide DB1831 and Its Mesylated Salt Form - DB1965 - against Trypanosoma cruzi Infection

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30356 ◽  
Author(s):  
Cristiane França da Silva ◽  
Denise da Gama Jaen Batista ◽  
Gabriel Melo Oliveira ◽  
Elen Mello de Souza ◽  
Erica Ripoll Hammer ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Salt Form ◽  
Cruzi Infection
Sign in / Sign up

Export Citation Format

Share Document