The class III antiarrhythmic agent E-4031 selectively blocks the inactivating inward-rectifying potassium current in rat anterior pituitary tumor cells (GH 3 /B 6 cells)

1997 ◽  
Vol 434 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Frank Weinsberg ◽  
Christiane K. Bauer ◽  
J. R. Schwarz
Keyword(s):  
Tumor Cells ◽  
Pituitary Tumor ◽  
Anterior Pituitary ◽  
Potassium Current ◽  
Antiarrhythmic Agent ◽  
Class Iii ◽  
Class Iii Antiarrhythmic Agent

Isoproterenol enhances a calcium-independent potassium current in mouse anterior pituitary tumor cells

1992 ◽  
Vol 68 (1) ◽  
pp. 117-123
Author(s):  
R. Weik ◽  
J. Spiess
Keyword(s):  
Tumor Cells ◽  
Pituitary Tumor ◽  
Anterior Pituitary ◽  
Potassium Current ◽  
Calcium Influx ◽  
Potassium Conductance ◽  
Patch Clamp Technique ◽  
Calcium Dependent ◽  
Gs Protein ◽  
Current Reduction

1. The patch-clamp technique was used to study the action of the beta-adrenergic agonist (-)-isoproterenol in anterior pituitary tumor cells of the mouse. 2. (-)-Isoproterenol induced an inward-rectifying potassium conductance with half-maximal stimulation at a concentration of approximately 67 nM. The isomer (+)-isoproterenol was less effective in stimulating the current. 3. The effect of (-)-isoproterenol was abolished by cholera toxin treatment, indicating the involvement of a Gs protein, whereas pertussis toxin treatment did not exhibit a current reduction. 4. We blocked or stimulated phosphorylation pathways in cells to test the involvement of adenosine 3',5'-cyclic monophosphate (cAMP). It was concluded that the current stimulation probably was not exclusively mediated by cAMP. 5. Activation of calcium-dependent potassium channels by an isoproterenol-induced calcium influx into the cell could be excluded. 6. Therefore it is suggested that the observed activation of a potassium current by isoproterenol could be directly mediated by a Gs protein

P173 effects of tetrahydroisoquinolines on the POMC gene expression in anterior pituitary tumor cells

1994 ◽  
Vol 2 (1-2) ◽  
pp. 162
Author(s):  
I. Putscher ◽  
H. Haber ◽  
J. Fickel ◽  
A. Winkler ◽  
M. Melzig
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Pituitary Tumor ◽  
Anterior Pituitary ◽  
Pomc Gene

scholarly journals EXPRESSION OF NEURAL CELL ADHESION MOLECULES IN THE MOUSE ANTERIOR PITUITARY GLAND AND PITUITARY TUMOR CELLS

1998 ◽  
Vol 19 (4) ◽  
pp. 269-277
Author(s):  
YOSHIHIRO YAYOI ◽  
SUMIO TAKAHASHI ◽  
SAKAE TAKEUCHI ◽  
MAKOTO TAKEUCHI ◽  
TATSUNORI SEKI ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Pituitary Gland ◽  
Tumor Cells ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Pituitary Tumor ◽  
Anterior Pituitary ◽  
Neural Cell ◽  
Neural Cell Adhesion Molecules ◽  
Neural Cell Adhesion

EGIS-7229, the new combined class III antiarrhythmic agent Lack of EAD inducing effect

1999 ◽  
Vol 32 (3) ◽  
pp. 329-333 ◽  
Author(s):  
Tamás Bányász ◽  
János Magyar ◽  
András Varró ◽  
Anikó Kovács ◽  
Ildikó Gyönös ◽  
...  
Keyword(s):  
Antiarrhythmic Agent ◽  
Class Iii ◽  
Class Iii Antiarrhythmic Agent
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