Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

1998 ◽  
Vol 77 (5) ◽  
pp. 457-461 ◽  
Author(s):  
Troels Dirch Poulsen ◽  
Tom Klausen ◽  
Jean-Paul Richalet ◽  
Inge-Lis Kanstrup ◽  
Niels Fogh-Andersen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Plasma Volume ◽  
Evans Blue ◽  
Acute Hypoxia ◽  
Dye Dilution ◽  
Rebreathing Method

The Use of Carbon Monoxide and T-1824 for Determining Blood Volume

1968 ◽  
Vol 14 (12) ◽  
pp. 1197-1205 ◽  
Author(s):  
L G Myhre ◽  
D K Brown ◽  
F G Hall ◽  
D B Dill
Keyword(s):  
Carbon Monoxide ◽  
Blood Volume ◽  
Young Women ◽  
Plasma Volume ◽  
Closed System ◽  
Evans Blue ◽  
The Other ◽  
Red Cell ◽  
Blood Volumes ◽  
Co Concentrations

Abstract Blood volume was determined with both T-1824 (Evans blue) and carbon monoxide (CO) for 2 young women, 2 young men, and 2 men ages 70 and 75. In the CO method a precise volume of CO was administered from a closed system, and the CO concentrations in blood were determined on the Van Slyke-Neill apparatus before and at the end of a 10-min. rebreathing period. The manometric technic is presented in detail and possible sources of errors are discussed. Comparisons were made during the spring in Indiana, in the hot desert, and at an altitude of 3800 m. Blood volume was taken as the sum of plasma volume (by T-1824 method) and red cell volume (by CO method); from these values body hematocrit was calculated. The ratios of body hematocrit to observed hematocrit ranged from 0.89 to 1.05 in 16 observations, with a median value of 0.93. In 12 of the 16, they ranged from 0.89 to 0.95, also with a median value of 0.93. Blood volumes determined by the CO method, using the 0.93 ratio, were within -1 to +4% of the blood volumes as determined above in 12 of 16 subjects. The other four differed by -7 to -13%.

scholarly journals Determination of plasma volume in anaesthetized piglets using the carbon monoxide (CO) method

2002 ◽  
Vol 36 (3) ◽  
pp. 344-350 ◽  
Author(s):  
J. K. Heltne ◽  
M. Farstad ◽  
T. Lund ◽  
M. E. Koller ◽  
K. Matre ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Plasma Volume ◽  
Evans Blue ◽  
Mean Difference ◽  
Limits Of Agreement ◽  
Administration System ◽  
Mean Values ◽  
Controlled Ventilation ◽  
The Mean

Based on measurements of the circulating red blood cell volume (VRBC) in seven anaesthetized piglets using carbon monoxide (CO) as a label, plasma volume (PV) was calculated for each animal. The increase in carboxyhaemoglobin (COHb) concentration following administration of a known amount of CO into a closed circuit re-breathing system was determined by diode-array spectrophotometry. Simultaneously measured haematocrit (HCT) and haemoglobin (Hb) values were used for PV calculation. The PV values were compared with simultaneously measured PVs determined using the Evans blue technique. Mean values (SD) for PV were 1708.6 (287.3)ml and 1738.7 (412.4)ml with the CO method and the Evans blue technique, respectively. Comparison of PVs determined with the two techniques demonstrated good correlation ( r = 0.995). The mean difference between PV measurements was -29.9 ml and the limits of agreement (mean difference ±2SD) were -289.1 ml and 229.3 ml. In conclusion, the CO method can be applied easily under general anaesthesia and controlled ventilation with a simple administration system. The agreement between the compared methods was satisfactory. Plasma volume determined with the CO method is safe, accurate and has no signs of major side effects.

Plasma Volume and Vascular Permeability during Hypoxia and Carbon Monoxide Exposure

1968 ◽  
Vol 21 ◽  
pp. 39-48 ◽  
Author(s):  
J. Siggaard-Andersen ◽  
F. Bonde Petersen ◽  
Thorsten Hansen ◽  
K. Mellemgaard
Keyword(s):  
Carbon Monoxide ◽  
Vascular Permeability ◽  
Plasma Volume

Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis

2020 ◽  
Vol 24 (2) ◽  
pp. 252-260 ◽  
Author(s):  
Tobias Bomholt ◽  
Sara Larsson ◽  
Marianne Rix ◽  
Sarah Rytter ◽  
Bo Feldt‐Rasmussen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Chronic Hemodialysis ◽  
Rebreathing Method

Lung diffusing capacity: rebreathing method, applicability in nonuniform ventilation

1965 ◽  
Vol 20 (1) ◽  
pp. 99-102 ◽  
Author(s):  
P. S⊘lvsteen
Keyword(s):  
Carbon Monoxide ◽  
Nonuniform Distribution ◽  
Diffusing Capacity ◽  
Carbon Monoxide Concentration ◽  
Straight Line ◽  
Co Concentration ◽  
Concentration Changes ◽  
Rectilinear Section ◽  
Rebreathing Method

We have calculated how the carbon monoxide concentration changes when subjects with different distributions of ventilation and lung diffusing capacity (Dl) respire in a small bag. The curve [loge CO concentration in the bag] versus [time] will sooner or later appear as a straight line. Dl is calculated from the slope of the rectilinear section of the curve and from lung and bag volume. If the curve becomes rectilinear within the period considered, Dl is calculated too low. In some cases the curve will not be rectilinear until more than 45 sec have passed, but will appear to be rectilinear during the period from 30 to 45 sec. If such an experiment is discontinued when 45 sec (the usual duration of experiment) have passed, Dl can be calculated at too high, at correct, or at too low values. nonuniform distribution of lung diffusing capacity Submitted on February 18, 1964

Effects of acute hypoxia on the adenylate cyclase and evans blue transport of brain microvessels

1987 ◽  
Vol 10 (4) ◽  
pp. 529-532 ◽  
Author(s):  
Géza Ádám ◽  
Ferenc Joó ◽  
Péter Temesvári ◽  
Ernö Dux ◽  
Péter Szerdahelyi
Keyword(s):  
Adenylate Cyclase ◽  
Evans Blue ◽  
Acute Hypoxia ◽  
Brain Microvessels

Plasma Volume and Vascular Permeability during Hypoxia and Carbon Monoxide Exposure

1968 ◽  
Vol 21 (sup103) ◽  
pp. 39-48 ◽  
Author(s):  
J. Siggaard-Andersen ◽  
F. Bonde Petersen ◽  
Thorsten I. Hansen ◽  
K. Mellemgaard
Keyword(s):  
Carbon Monoxide ◽  
Vascular Permeability ◽  
Plasma Volume

scholarly journals Estimating plasma volume in neonatal Holstein calves fed one or two feedings of a lacteal-based colostrum replacer using Evans blue dye and hematocrit values at various time points

2015 ◽  
Vol 95 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Rosemarie G. Cabral ◽  
Colleen E. Chapman ◽  
Emily J. Kent ◽  
Peter S. Erickson
Keyword(s):  
Body Weight ◽  
Plasma Volume ◽  
Evans Blue ◽  
Treatment Effects ◽  
Birth Date ◽  
Blue Dye ◽  
Time Points ◽  
Evans Blue Dye ◽  
Holstein Calves ◽  
Feeding Regimen

Cabral, R. G., Chapman, C. E., Kent, E. J. and Erickson, P. S. 2015. Estimating plasma volume in neonatal Holstein calves fed one or two feedings of a lacteal-based colostrum replacer using Evans blue dye and hematocrit values at various time points. Can. J. Anim. Sci. 95: 293–298. Twenty-eight Holstein calves were blocked by birth date and randomly assigned to one of two treatments to investigate the effect of colostrum replacer (CR) feeding regimen on plasma volume (PV). Treatments were: (1) one feeding of CR (C1; 3 L of reconstituted CR 675 g of powder providing 184.5 g of IgG at birth) or (2) two feedings of CR (C2; 2 L of reconstituted CR at birth and 1 L of reconstituted CR at 6 h). By 6 h of age, all calves had received 3 L of CR providing 184.5 g of IgG. Plasma volume was estimated at 6, 12, 18, and 24 h after birth using Evans blue dye. No treatment effects were noted at any time points (P>0.05). Mean PV for all calves regardless of treatment at 6, 12, 18, and 24 h were 78.6, 89.2, 83.9, and 90.7 mL kg−1 of body weight, respectively. Plasma volume was correlated with hematocrit (HCT), initial HCT, and treatment. Hematocrit was correlated with PV, initial HCT, and body weight. Hematocrit for 6, 12, 18 and 24 h after birth can be predicted with an initial precolostral HCT determination.

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