Beneficial clinical effects of cyclosporin A on severe psoriasis and its dissociation from serum concentration of soluble interleukin-2 receptor, soluble interleukin-6 receptor, soluble CD14 antigen, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1

1996 ◽  
Vol 289 (1) ◽  
pp. 57-59 ◽  
Author(s):  
T. Yamamoto ◽  
Kyoko Kimura ◽  
Ichiro Katayama ◽  
Taeko Koyano ◽  
Akira Mamada ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Interleukin 2 ◽  
Intercellular Adhesion Molecule ◽  
Clinical Effects ◽  
Intercellular Adhesion Molecule 1 ◽  
Soluble Cd14 ◽  
Interleukin 6 Receptor ◽  
Soluble Interleukin 2 Receptor ◽  
Soluble Intercellular Adhesion Molecule ◽  
Cell Adhesion Molecule 1

scholarly journals Detection of soluble interleukin-2 receptor and soluble intercellular adhesion molecule-1 in the effusion of otitis media with effusion

1995 ◽  
Vol 4 (5) ◽  
pp. 350-354 ◽  
Author(s):  
T. Ganbo ◽  
K.-I. Hisamatsu ◽  
H. Inoue ◽  
K. Kikushima ◽  
A. Mizukoshi ◽  
...  
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Interleukin 2 ◽  
Intercellular Adhesion Molecule ◽  
Healthy Controls ◽  
Intercellular Adhesion Molecule 1 ◽  
Cytokine Network ◽  
Tnf Α ◽  
Soluble Interleukin 2 Receptor ◽  
Soluble Intercellular Adhesion Molecule

We measured sIL-2R, TNF-α and sICAM-1 in the sera and middle ear effusions (MEEs) of patients with otitis media with effusion (OME). Although there was no signmcant difference between the sIL-2R levels of the serous and mucoid MEEs, they were significantly higher than serum sIL-2R levels of OME patients and healthy controls. TNF-α levels of the mucoid MEEs were significantly higher than those of the serous type. However, TNF-α was rarely detected in the sera of OME patients or healthy controls. We observed significant differences between the serous and mucoid MEEs with respect to their sICAM-1 levels, which were also higher than serum slCAM-1 levels of OME patients and healthy controls. Our findings suggested that IL-2, TNF-α and ICAM-1 could be significantly involved in the pathogenesis of OME through the cytokine network.

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