Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas

1997 ◽  
Vol 93 (5) ◽  
pp. 518-527 ◽  
Author(s):  
S. Y. Leung ◽  
Maria Pik Wong ◽  
Lap Ping Chung ◽  
Annie Shuk Yee Chan ◽  
Siu Tsan Yuen
Keyword(s):  
Macrophage Infiltration ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1254-1261 ◽  
Author(s):  
E. A. Kirk ◽  
Z. K. Sagawa ◽  
T. O. McDonald ◽  
K. D. O'Brien ◽  
J. W. Heinecke
Keyword(s):  
Adipose Tissue ◽  
Macrophage Infiltration ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury

2000 ◽  
Vol 58 (6) ◽  
pp. 2408-2419 ◽  
Author(s):  
Karl F. Hilgers ◽  
Andrea Hartner ◽  
Markus Porst ◽  
Monika Mai ◽  
Michael Wittmann ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Macrophage Infiltration ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Expression of monocyte chemoattractant protein-1 in meningioma

1995 ◽  
Vol 82 (5) ◽  
pp. 874-878 ◽  
Author(s):  
Kyoichi Sato ◽  
Jun-Ichi Kuratsu ◽  
Hideo Takeshima ◽  
Teizo Yoshimura ◽  
Yukitaka Ushio
Keyword(s):  
Culture Fluid ◽  
Glioma Cell Line ◽  
Macrophage Infiltration ◽  
Content Type ◽  
Monocyte Chemoattractant Protein 1 ◽  
Messenger Ribonucleic Acid ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Perifocal Edema ◽  
Fine Print

✓ Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage accumulation is one of the pathological features of meningioma. To investigate the mechanism of macrophage infiltration into meningioma, the expression and localization of MCP-1 in 16 cases of meningioma were studied using Northern blot analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 messenger ribonucleic acid and protein, and some degree of macrophage infiltration was seen in all 16 meningiomas. There was a relationship between MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly expressed in meningiomas with a high degree of macrophage infiltration. Sometimes the meningioma was accompanied by perifocal edema; a correlation between macrophage infiltration into brain tumors and perifocal edema has already been reported. It was found that the degree of MCP-1 expression is not correlated with the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an important role in macrophage infiltration into meningioma.

scholarly journals An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice

Endocrinology ◽  
2010 ◽  
Vol 151 (3) ◽  
pp. 971-979 ◽  
Author(s):  
Sanshiro Tateya ◽  
Yoshikazu Tamori ◽  
Takayuki Kawaguchi ◽  
Hajime Kanda ◽  
Masato Kasuga
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Macrophage Infiltration ◽  
Whole Body ◽  
Adipose Tissue Inflammation ◽  
Monocyte Chemoattractant Protein 1 ◽  
Tissue Inflammation ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Systemic Insulin Resistance

Chronic inflammation in adipose tissue is thought to be important for the development of insulin resistance in obesity. Furthermore, the level of monocyte chemoattractant protein-1 (MCP-1) is increased not only in adipose tissue but also in the circulation in association with obesity. However, it has remained unclear to what extent the increased circulating level of MCP-1 contributes to insulin resistance. We have now examined the relevance of circulating MCP-1 to the development of insulin resistance in mice. The plasma concentration of MCP-1 was increased chronically or acutely in mice to the level observed in obese animals by chronic subcutaneous infusion of recombinant MCP-1 with an osmotic pump or by acute intravenous infusion of MCP-1 with an infusion pump, respectively. Whole-body metabolic parameters as well as inflammatory changes in adipose tissue were examined. A chronic increase in the circulating level of MCP-1 induced insulin resistance, macrophage infiltration into adipose tissue, and an increase in hepatic triacylglycerol content. An acute increase in the circulating MCP-1 concentration also induced insulin resistance but not macrophage infiltration into adipose tissue. In addition, inhibition of signaling by MCP-1 and its receptor CCR2 by administration of a novel CCR2 antagonist ameliorated insulin resistance in mice fed a high-fat diet without affecting macrophage infiltration into adipose tissue. These data indicate that an increase in the concentration of MCP-1 in the circulation is sufficient to induce systemic insulin resistance irrespective of adipose tissue inflammation.

Sign in / Sign up

Export Citation Format

Share Document