Enzymatic hydrolysis by Humicola lanuginosa lipase of poly(lactic acid)-poly(glycolic acid) monolayers

2000 ◽  
Vol 278 (8) ◽  
pp. 719-727 ◽  
Author(s):  
Tz. Ivanova ◽  
A. Svendsen ◽  
R. Verger ◽  
I. Panaiotov
Keyword(s):  
Lactic Acid ◽  
Enzymatic Hydrolysis ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Humicola Lanuginosa ◽  
Humicola Lanuginosa Lipase

scholarly journals Mechanical Properties and Bioactivity of Poly(Lactic Acid) Composites Containing Poly(Glycolic Acid) Fiber and Hydroxyapatite Particles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 249
Author(s):  
Han-Seung Ko ◽  
Sangwoon Lee ◽  
Doyoung Lee ◽  
Jae Young Jho
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Flexural Strength ◽  
Interfacial Adhesion ◽  
Glycolic Acid ◽  
Compact Bone ◽  
Poly Lactic Acid ◽  
Coupling Reactions ◽  
The Poor ◽  
Human Compact Bone

To enhance the mechanical strength and bioactivity of poly(lactic acid) (PLA) to the level that can be used as a material for spinal implants, poly(glycolic acid) (PGA) fibers and hydroxyapatite (HA) were introduced as fillers to PLA composites. To improve the poor interface between HA and PLA, HA was grafted by PLA to form HA-g-PLA through coupling reactions, and mixed with PLA. The size of the HA particles in the PLA matrix was observed to be reduced from several micrometers to sub-micrometer by grafting PLA onto HA. The tensile and flexural strength of PLA/HA-g-PLA composites were increased compared with those of PLA/HA, apparently due to the better dispersion of HA and stronger interfacial adhesion between the HA and PLA matrix. We also examined the effects of the length and frequency of grafted PLA chains on the tensile strength of the composites. By the addition of unidirectionally aligned PGA fibers, the flexural strength of the composites was greatly improved to a level comparable with human compact bone. In the bioactivity tests, the growth of apatite on the surface was fastest and most uniform in the PLA/PGA fiber/HA-g-PLA composite.

scholarly journals Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis

2010 ◽  
Vol 159 (5) ◽  
pp. 1126-1132 ◽  
Author(s):  
André C Amaral ◽  
Alexandre F Marques ◽  
Julián E Muñoz ◽  
Anamélia L Bocca ◽  
Andreza R Simioni ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Immunological Protection

Superhydrophobic functionalization of cutinase activated poly(lactic acid) surfaces

2017 ◽  
Vol 19 (3) ◽  
pp. 816-822 ◽  
Author(s):  
A. Ortner ◽  
A. Pellis ◽  
C. Gamerith ◽  
A. Orcal Yebra ◽  
D. Scaini ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Enzymatic Hydrolysis ◽  
Ring Opening ◽  
Superhydrophobic Surfaces ◽  
Poly Lactic Acid ◽  
Hydrolysis Of

Controlled enzymatic hydrolysis of PLA surfaces, followed by ring opening of AKD, leads to superhydrophobic surfaces (WCA >150°).

Engineering microenvironment of biodegradable polyester systems for drug stability and release control

2021 ◽  
Author(s):  
Nisar Ul Khaliq ◽  
Dhawal Chobisa ◽  
Coralie A Richard ◽  
Monica R Swinney ◽  
Yoon Yeo
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
Drug Stability ◽  
Poly Lactic Acid ◽  
Polymeric Systems ◽  
Us Fda ◽  
History Of Use ◽  
Release Control

Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.

Characterization of a novel bioactive poly[(lactic acid)-co-(glycolic acid)] and collagen hybrid matrix for dermal regeneration

2005 ◽  
Vol 54 (10) ◽  
pp. 1449-1457 ◽  
Author(s):  
Kee Woei Ng ◽  
Jevon Louis ◽  
Barnabas Saey Tuan Ho ◽  
Hosur N Achuth ◽  
Jia Lu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Hybrid Matrix ◽  
Dermal Regeneration
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