Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes

2000 ◽  
Vol 39 (6) ◽  
pp. 270-276 ◽  
Author(s):  
Y. Amet ◽  
E. Plée-Gautier ◽  
F. Berthou ◽  
F. Adas ◽  
S.W. French
Hepatology ◽  
1999 ◽  
Vol 29 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Virginie Fataccioli ◽  
Evelyne Andraud ◽  
Monique Gentil ◽  
Samuel W. French ◽  
Helene Rouach

1988 ◽  
Vol 251 (2) ◽  
pp. 547-551 ◽  
Author(s):  
J S Wilson ◽  
M A Korsten ◽  
L P Donnelly ◽  
P W Colley ◽  
J B Somer ◽  
...  

Administration of ethanol as part of a nutritionally adequate liquid diet to female Wistar rats was found to depress markedly incorporation of labelled glucose into adipose-tissue acylglycerol fatty acids. Similar results with labelled pyruvate and acetate suggested inhibition of the fatty-acid-synthesis pathway at, or distal to, the acetyl-CoA carboxylase step. Activities of acetyl-CoA carboxylase and fatty acid synthetase were markedly lower in ethanol-fed animals. The activity of another lipogenic enzyme, phosphatidate phosphohydrolase, was not affected by chronic ethanol feeding. These findings suggest that chronic ethanol administration has marked effects on adipose-tissue lipogenesis.


1998 ◽  
Vol 28 ◽  
pp. 220
Author(s):  
M Simoncini ◽  
A Gasbarrini ◽  
G. Addolorato ◽  
P Pasini ◽  
B Nardo ◽  
...  

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