Immunological aspects of the potential role of dietary carbohydrates and lectins in human health

1999 ◽  
Vol 38 (3) ◽  
pp. 107-117 ◽  
Author(s):  
D.C. Kilpatrick
2020 ◽  
Vol 8 (3) ◽  
pp. 206-214
Author(s):  
Xiaoli Zhang ◽  
Zui Pan

Abstract Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.


2021 ◽  
Vol 26 (A) ◽  
pp. e989
Author(s):  
Rosa Anna Milella ◽  
Marica Gasparro ◽  
Fiammetta Alagna ◽  
Maria Francesca Cardone ◽  
Silvia Rotunno ◽  
...  

2020 ◽  
Vol 4 (5) ◽  
pp. 473-483 ◽  
Author(s):  
Glyn Jones ◽  
Adam Kleczkowski

Plant health is relatively poorly funded compared with animal and human health issues. However, we contend it is at least as complex and likely more so given the number of pests and hosts and that outbreaks occur in poorly monitored open systems. Modelling is often suggested as a method to better consider the threats to plant health to aid resource and time poor decision makers in their prioritisation of responses. However, like other areas of science, the modelling community has not always provided accessible and relevant solutions. We describe some potential solutions to developing plant health models in conjunction with decision makers based upon a recent example and illustrate how an increased emphasis on plant health is slowly expanding the potential role of modelling in decision making. We place the research in the Credibility, Relevance and Legitimacy (CRELE) framework and discuss the implications for future developments in co-construction of policy-linked models.


2012 ◽  
Vol 52 (7) ◽  
pp. 383 ◽  
Author(s):  
Wayne L. Bryden

G. L. McClymont developed a unique paradigm in which to consider the challenges that confront agriculture and it is based on an understanding of the interrelationships of plants, animals, soils and water within an economic and social framework. The major changes in our environment are the consequence of rapid population growth and the need to increase world food supplies. Within this context, this paper provides an overview of the link between agriculture, especially animal production and population health and how mycotoxins, fungal secondary metabolites, can perturb this link. Examples from New Zealand and Australian animal agriculture are described. The underlying premise of this paper is that agriculture is a major determinant of human health through the supply of food derived from both plant and animal sources. In other words, nutrition is the conduit between agriculture and human health. Against this backdrop the potential role of mycotoxins in determining food and feed supplies is discussed. Globally, mycotoxins have significant human and animal health, economic and international trade implications.


Author(s):  
D. L. Cracknell ◽  
S. Pahl ◽  
M. P. White ◽  
M. H. Depledge

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 110-113
Author(s):  
DERRICK B. JELLIFFE ◽  
E. F. PATRICE JELLIFFE

The pioneer research and writings by Hendrickse on the human health hazards of aflatoxins, including their potential role in the etiology of kwashiorkor, are of great importance.1,2 They draw attention to at least some of the wealth of mycotoxicological information sometimes inadequately recognized by pediatricians and other health professionals. However, while acknowledging the significance of this underemphasized linkage and the need for much further communication between workers in the various highly complex fields involved, a different interpretation of the potential role of aflatoxins in the etiology of kwashiorkor needs consideration, based on present evidence. The converse is also true, as the focus of mycotoxicologists regarding human pathology seems mainly concerned with cancer of the liver.


mBio ◽  
2017 ◽  
Vol 8 (6) ◽  
Author(s):  
Kaisa Koskinen ◽  
Manuela R. Pausan ◽  
Alexandra K. Perras ◽  
Michael Beck ◽  
Corinna Bang ◽  
...  

ABSTRACT Human-associated archaea remain understudied in the field of microbiome research, although in particular methanogenic archaea were found to be regular commensals of the human gut, where they represent keystone species in metabolic processes. Knowledge on the abundance and diversity of human-associated archaea is extremely limited, and little is known about their function(s), their overall role in human health, or their association with parts of the human body other than the gastrointestinal tract and oral cavity. Currently, methodological issues impede the full assessment of the human archaeome, as bacteria-targeting protocols are unsuitable for characterization of the full spectrum of Archaea. The goal of this study was to establish conservative protocols based on specifically archaea-targeting, PCR-based methods to retrieve first insights into the archaeomes of the human gastrointestinal tract, lung, nose, and skin. Detection of Archaea was highly dependent on primer selection and the sequence processing pipeline used. Our results enabled us to retrieve a novel picture of the human archaeome, as we found for the first time Methanobacterium and Woesearchaeota (DPANN superphylum) to be associated with the human gastrointestinal tract and the human lung, respectively. Similar to bacteria, human-associated archaeal communities were found to group biogeographically, forming (i) the thaumarchaeal skin landscape, (ii) the (methano)euryarchaeal gastrointestinal tract, (iii) a mixed skin-gastrointestinal tract landscape for the nose, and (iv) a woesearchaeal lung landscape. On the basis of the protocols we used, we were able to detect unexpectedly high diversity of archaea associated with different body parts. IMPORTANCE In summary, our study highlights the importance of the primers and data processing pipeline used to study the human archaeome. We were able to establish protocols that revealed the presence of previously undetected Archaea in all of the tissue samples investigated and to detect biogeographic patterns of the human archaeome in the gastrointestinal tract and on the skin and for the first time in the respiratory tract, i.e., the nose and lungs. Our results are a solid basis for further investigation of the human archaeome and, in the long term, discovery of the potential role of archaea in human health and disease. IMPORTANCE In summary, our study highlights the importance of the primers and NGS data processing pipeline used to study the human archaeome. We were able to establish protocols that revealed the presence of previously undetected Archaea in all of the tissue samples investigated and to detect biogeographic patterns of the human archaeome in the gastrointestinal tract, on the skin, and for the first time in the respiratory tract, i.e., the nose and lungs. Our results are a solid basis for further investigation of the human archaeome and, in the long term, discovery of the potential role of archaea in human health and disease.


Nutrients ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 466-488 ◽  
Author(s):  
Joanna Fiedor ◽  
Květoslava Burda

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