The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts

1999 ◽  
Vol 10 (10) ◽  
pp. 1032-1035 ◽  
Author(s):  
Sidong Huang ◽  
Jeremiah M. Scharf ◽  
Joseph D. Growney ◽  
Matthew G. Endrizzi
Keyword(s):  
Gene Cluster ◽  
Chromosome 13 ◽  
Naip Gene

Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome

1993 ◽  
Vol 13 (10) ◽  
pp. 6064-6070
Author(s):  
Y P Li ◽  
R Tomanin ◽  
J R Smiley ◽  
S Bacchetti
Keyword(s):  
Human Genome ◽  
Gene Cluster ◽  
Fragile Site ◽  
Adenovirus Type ◽  
Fragile Sites ◽  
Human Cells ◽  
Major Site ◽  
Chromosome 13 ◽  
Direct Assessment

Infection with adenovirus type 12 (Ad12) induces four fragile sites in the human genome (H.F. Stich, G.L. van Hoosier, and J.J. Trentin, Exp. Cell Res. 34:400-403, 1964; H. zur Hausen, J. Virol. 1:1174-1185, 1967). The major site, at 17q21-22, contains the U2 gene cluster, which is specifically disrupted by infection in at least a percentage of the cells (D.M. Durnam, J.C. Menninger, S.H. Chandler, P.P. Smith, and J.K. McDougall, Mol. Cell. Biol. 8:1863-1867, 1988). For direct assessment of whether the U2 locus is the target of the Ad12 effect, an artificial locus, constructed in vitro and consisting of tandem arrays of the U2 6-kbp monomer, was transfected into human cells. We report that integration of this artificial locus on the p arm of chromosome 13 creates a new Ad12-inducible fragile site.

scholarly journals Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.

1996 ◽  
Vol 6 (8) ◽  
pp. 688-701 ◽  
Author(s):  
Z F Wang ◽  
T Krasikov ◽  
M R Frey ◽  
J Wang ◽  
A G Matera ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Histone Gene ◽  
Histone Genes ◽  
Chromosome 13

scholarly journals Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome.

1993 ◽  
Vol 13 (10) ◽  
pp. 6064-6070 ◽  
Author(s):  
Y P Li ◽  
R Tomanin ◽  
J R Smiley ◽  
S Bacchetti
Keyword(s):  
Human Genome ◽  
Gene Cluster ◽  
Fragile Site ◽  
Adenovirus Type ◽  
Fragile Sites ◽  
Human Cells ◽  
Major Site ◽  
Chromosome 13 ◽  
Direct Assessment

Infection with adenovirus type 12 (Ad12) induces four fragile sites in the human genome (H.F. Stich, G.L. van Hoosier, and J.J. Trentin, Exp. Cell Res. 34:400-403, 1964; H. zur Hausen, J. Virol. 1:1174-1185, 1967). The major site, at 17q21-22, contains the U2 gene cluster, which is specifically disrupted by infection in at least a percentage of the cells (D.M. Durnam, J.C. Menninger, S.H. Chandler, P.P. Smith, and J.K. McDougall, Mol. Cell. Biol. 8:1863-1867, 1988). For direct assessment of whether the U2 locus is the target of the Ad12 effect, an artificial locus, constructed in vitro and consisting of tandem arrays of the U2 6-kbp monomer, was transfected into human cells. We report that integration of this artificial locus on the p arm of chromosome 13 creates a new Ad12-inducible fragile site.

NAIP Gene

2020 ◽  
Author(s):  
Keyword(s):  
Naip Gene

OMIC gene cluster evaluation amplifies the prognostic accuracy of the NETest

2020 ◽  
Author(s):  
Mark Kidd ◽  
Alexandra Kitz ◽  
Ignat Drozdov ◽  
Irvin Modlin
Keyword(s):  
Gene Cluster ◽  
Prognostic Accuracy ◽  
Cluster Evaluation

Anacyclamide D8P, a prenylated cyanobactin from a Sphaerospermopsis sp. cyanobacterium

2017 ◽  
Author(s):  
Joana Martins ◽  
Niina Leikoski ◽  
Matti Wahlsten ◽  
Joana Azevedo ◽  
Jorge Antunes ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Cyclic Peptides ◽  
Biosynthetic Gene Cluster ◽  
The Novel ◽  
Tyrosine Residue ◽  
Biosynthetic Gene ◽  
Post Translational Modification ◽  
Biological Assays ◽  
Mass Spectrometric Data ◽  
Spectrometric Data

Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. Anacyclamides are macrocyclic cyanobactins with a highly diverse sequence that are common in the genus <i>Anabaena</i>. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, anacyclamide D8P (<b>1</b>), from <i>Sphaerospermopsis</i> sp. LEGE 00249. The anacyclamide biosynthetic gene cluster (<i>acy</i>) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the acy gene cluster in <i>Escherichia</i> <i>coli</i> established the connection between genomic and mass spectrometric data. Unambiguous establishment of the type and site of prenylation required the full structural elucidation of <b>1</b> using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound <b>1</b> was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium <i>Halomonas aquamarina</i> CECT 5000.<br>

Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching

2018 ◽  
Author(s):  
William A. Shirley ◽  
Brian P. Kelley ◽  
Yohann Potier ◽  
John H. Koschwanez ◽  
Robert Bruccoleri ◽  
...  
Keyword(s):  
Natural Products ◽  
Open Source ◽  
Natural Product ◽  
Gene Cluster ◽  
Public Domain ◽  
Product Structure ◽  
Fingerprint Matching ◽  
Ensemble Modeling ◽  
Chemical Structures ◽  
Source Gene

This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed. All structures are public domain molecules and have been reviewed for release.

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