Effects of Polyglycolic Acid and Polypropylene Meshes on Postoperative Adhesion Formation in Mice

1997 ◽  
Vol 21 (6) ◽  
pp. 579-583 ◽  
Author(s):  
Atac Baykal ◽  
Demirali Onat ◽  
Kemal Rasa ◽  
Nurten Renda ◽  
Iskender Sayek
Keyword(s):  
Adhesion Formation ◽  
Polyglycolic Acid ◽  
Postoperative Adhesion

scholarly journals Newly Developed Polyglycolic Acid Reinforcement Unified with Sodium Alginate to Prevent Adhesion

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Shinichiro Morita ◽  
Toshitaka Takagi ◽  
Rie Abe ◽  
Hiroyuki Tsujimoto ◽  
Yuki Ozamoto ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Sodium Alginate ◽  
Calcium Alginate ◽  
Adhesion Formation ◽  
Polyglycolic Acid ◽  
Collagen Fibers ◽  
Postoperative Adhesion ◽  
Step Procedure ◽  
One Step ◽  
Excessive Proliferation

Polyglycolic acid (PGA) mesh fabric is widely used for reinforcing injured tissues during surgeries. However, PGA induces chronic inflammation and adhesion. The purpose of this study is to develop PGA reinforcement “without PGA-induced adhesion.” We developed a reinforcement fabric unified with PGA mesh and alginate foam. The antiadhesive effects of sodium alginate foam and calcium alginate foam were evaluated in rats. Sodium alginate foam unified with PGA mesh fabric exhibited strong effects that limit the extent and severity of adhesion, whereas calcium alginate foam unified with PGA mesh was less effective in preventing adhesion. In the sodium alginate group, fibroblasts and collagen fibers around implanted sites were sparse and the material degraded rapidly by macrophage ingestion. Fibroblasts and collagen fibers play a major role in adhesion formation and their excessive proliferation results in postoperative adhesion. Thus, inhibiting their increase is the key in preventing PGA-induced adhesion. The reinforcement that is composed of PGA mesh unified with sodium alginate foam strongly inhibited PGA-induced adhesion and showed excellent handling during surgery and could be easily applied with a one-step procedure.

The Effect of Disulfiram in the Prevention of Postoperative Adhesion Formation in an Experimental Rat Uterine Horn Model

2021 ◽  
Author(s):  
Yıldız Akdaş Reis ◽  
Omer Lutfi Tapisiz ◽  
Ümit Göktolga ◽  
Gülçin Şimşek ◽  
Özlem Erten ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Uterine Horn ◽  
Postoperative Adhesion

Effects of Intraperitoneal Bevacizumab Administration on Colonic Anastomosis and Early Postoperative Adhesion Formation

2013 ◽  
Vol 20 (6) ◽  
pp. 559-565 ◽  
Author(s):  
Hasan Karanlik ◽  
Atilla Kurt ◽  
Enver Kunduz ◽  
Kursat Serin ◽  
Sezer Saglam ◽  
...  
Keyword(s):  
Colonic Anastomosis ◽  
Adhesion Formation ◽  
Postoperative Adhesion

scholarly journals Comparison of Honey versus Polylactide Anti-Adhesion Barrier on Peritoneal Adhesion and Healing of Colon Anastomosis in Rabbits

2019 ◽  
Vol 7 (10) ◽  
pp. 1597-1601 ◽  
Author(s):  
Ali Reza Negahi ◽  
Parisa Hosseinpour ◽  
Mohammad Vaziri ◽  
Hamed Vaseghi ◽  
Pedram Darvish ◽  
...  
Keyword(s):  
Intestinal Anastomosis ◽  
Adhesion Formation ◽  
Postoperative Adhesion ◽  
Control Group ◽  
Colon Anastomosis ◽  
Human Beings ◽  
Peritoneal Adhesion ◽  
Adhesion Barrier ◽  
Anastomosis Leakage ◽  
Barrier Film

BACKGROUND: Postoperative adhesion is still a consequence of intra-abdominal surgeries, which results in bowel obstruction and abdominopelvic pain. Bowel anastomosis as a common abdominal surgery has the incidence of leakage in up to 30% of patients that increase morbidity and mortality. Due to similar pathways of adhesion formation and wound healing, it is important to find a way to reduce adhesions and anastomosis leakage. AIM: This study was designed to compare antiadhesive as well as anastomosis healing improvement effect of honey and polylactide anti-adhesive barrier film. METHODS: Forty-five rabbits divided into three groups of honey, adhesion barrier film, and control group in an animal study. Under a similar condition, rabbits underwent resection and anastomosis of cecum under general anaesthesia. In the first group, honey was used at the anastomosis site, in the second one polylactide adhesion barrier film utilised, and the third one was the control group. Adhesion, as well as anastomosis leakage, was assessed after 21 days. Data were analysed using the Statistical Package for Social Scientists (SPSS) for Windows version 25. RESULTS: Three groups of 15 rabbits were studied. The results showed that mean peritoneal adhesion score (PAS) was lower in the honey group (1.67) in comparison to the adhesion barrier film group (3.40) and the control group (6.33). CONCLUSION: Bio-absorbable polylactide barrier has an anti-adhesion effect but is not suitable for intestinal anastomosis in rabbits. Further studies needed to evaluate these effects on human beings.

Role of Substance P–Dependent Chemotactic Signaling in Postoperative Adhesion Formation

2022 ◽  
Vol 270 ◽  
pp. 49-57
Author(s):  
Hisashi Kosaka ◽  
Masaki Kaibori ◽  
Daniel I. Chu ◽  
Arthur F Stucchi ◽  
Mitsugu Sekimoto
Keyword(s):  
Substance P ◽  
Adhesion Formation ◽  
Postoperative Adhesion

Effect of Intraperitoneal Instillation of 32% Dextran 70 on Postoperative Adhesion Formation after Tubal Surgery

1986 ◽  
Vol 41 (7) ◽  
pp. 461-462
Author(s):  
B. LARSSON ◽  
O. LALOS ◽  
L. MARSK ◽  
S-E. TRONSTAD ◽  
M. BYGDEMAN ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Postoperative Adhesion ◽  
Dextran 70 ◽  
Intraperitoneal Instillation ◽  
Tubal Surgery

scholarly journals The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

2011 ◽  
Vol 26 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Hamit Yildiz ◽  
Ali Said Durmus ◽  
Halil Simsek ◽  
Ihsan Yaman
Keyword(s):  
Vitamin E ◽  
Saline Solution ◽  
Adhesion Formation ◽  
Uterine Horn ◽  
Postoperative Adhesion ◽  
Mononuclear Cell Infiltration ◽  
The Third ◽  
Methylen Blue ◽  
Histopathologic Evaluation ◽  
Adhesion Model

Purpose: To compare the effects of vitamin E and 1% methylen blue solutions on prevention of experimentally induced adhesions in rats. Methods: Thirty seven female Spraque Dawley rats were randomized into four groups. First group was kept as sham operated group. An adhesion model was constituted on the left uterine horn of the other groups. The lesion areas of rats from the second, the third and the fourth groups were coated with 2 ml 0.9 % saline solution (C group), 10 mg vitamin E (VE group) and 1% methylen blue solutions (MB group), respectively. Results: Histopathologically, adhesion scores, mononuclear cell infiltration, oedema and fibrosis were more prominent in the MB group compared with C and VE groups. There were no significant differences between the groups in tissue glutathione peroxidase (GPx), catalase (CAT) activities and glutation (GSH) level, these parameters were slightly increased in group with VE supplementation though. The administration of VE and MB significantly decreased NO (P<0.01) levels when compared to the C group. The level of malondialdehyde (MDA) in the VE group was significantly lower (P<0.05) than those of the Sh and C groups. Conclusion: Intraperitoneal methylen blue solutions treatments were more effective according to vitamin E in preventing the formation of intra-abdominal adhesion in a rat uterine horn model.

A comparison of thermal injury, healing patterns, and postoperative adhesion formation following CO2 laser and electromicrosurgery

1987 ◽  
Vol 48 (6) ◽  
pp. 1025-1029 ◽  
Author(s):  
Anthony A. Luciano ◽  
Gail Whitman ◽  
Donald B. Maier ◽  
John Randolph ◽  
Ronald Maenza
Keyword(s):  
Co2 Laser ◽  
Thermal Injury ◽  
Adhesion Formation ◽  
Postoperative Adhesion
Sign in / Sign up

Export Citation Format

Share Document