Poor induction of interleukin-2 receptor expression on CD8bright + cells in whole blood cell cultures with CD3 mAb. Implications for immunotherapy with CD3 mAb

1994 ◽  
Vol 38 (1) ◽  
pp. 53-60
Author(s):  
Richard A. J. Janssen ◽  
Agnes A. Heijn ◽  
T. Hauw The ◽  
Lou de Leij
Keyword(s):  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Interleukin 2 ◽  
Receptor Expression ◽  
Interleukin 2 Receptor ◽  
Whole Blood Cell Cultures

Recombinant Human Erythropoietin Stimulates Production of Interleukin 2 by Whole Blood Cell Cultures of Hemodialysis Patients

1999 ◽  
Vol 23 (9) ◽  
pp. 809-816 ◽  
Author(s):  
Ewa Bryl ◽  
Jolanta Myśliwska ◽  
Alicja Dębska‐Ślizień ◽  
Piotr Trzonkowski ◽  
Dominik Rachoń ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Recombinant Human Erythropoietin ◽  
Interleukin 2 ◽  
Hemodialysis Patients ◽  
Human Erythropoietin ◽  
Whole Blood Cell Cultures

Cytokine production in human whole blood cell cultures of patients with multiple sclerosis: Evidence for Th1 or Th2?

1994 ◽  
Vol 54 (1-2) ◽  
pp. 189
Author(s):  
J. Philippé ◽  
D. Degroote ◽  
J. Debruyne ◽  
G. Leroux-Roels ◽  
A. Willems ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Cytokine Production ◽  
Human Whole Blood ◽  
Whole Blood Cell Cultures

Cytokine Levels in Whole Blood Cell Cultures of Oral Contraceptive Users and Pregnant Women

1992 ◽  
Vol 5 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Ursula Elsässer-Beile ◽  
Sabine Von Kleist ◽  
P. Hölsch ◽  
J. Schulte Mönting ◽  
Inna Werner
Keyword(s):  
Oral Contraceptive ◽  
Blood Cell ◽  
Pregnant Women ◽  
Cell Cultures ◽  
Oral Contraceptives ◽  
Whole Blood ◽  
Tnf Alpha ◽  
Ifn Gamma ◽  
Cytokine Levels ◽  
Whole Blood Cell Cultures

The production of the cytokines IFN-gamma, IL-2, IL-1-alpha and TNF-alpha was investigated in the supernatants of mitogen-stimulated whole blood cell cultures from 52 oral contraceptive users, 33 pregnant women and 75 female controls. Cells from women taking oral contraceptives produced significantly less IFN-gamma (p≤0.05) and TNF-alpha (p≤0.05) compared to the controls. In the cultures of the pregnant women significantly lower levels of IFN-gamma (p≤0.01), IL-2 (p ≤0.001) and TNF-alpha (p≤0.01) were found than in those of the controls. Total and differential leukocyte counts were almost identical in all three groups of women. It is suggested, that lymphocyte and monocyte function as measured by cytokine production is altered in women taking oral contraceptives and in pregnant women.

scholarly journals Impaired cytokine production in whole blood cell cultures of patients with gynaecological carcinomas in different clinical stages

1993 ◽  
Vol 68 (1) ◽  
pp. 32-36 ◽  
Author(s):  
U Elsässer-Beile ◽  
S von Kleist ◽  
W Sauther ◽  
H Gallati ◽  
J Schulte Mönting
Keyword(s):  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Cytokine Production ◽  
Clinical Stages ◽  
Whole Blood Cell Cultures

scholarly journals Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures.

1992 ◽  
Vol 90 (5) ◽  
pp. 1944-1951 ◽  
Author(s):  
E Arzt ◽  
G Stelzer ◽  
U Renner ◽  
M Lange ◽  
O A Müller ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Interleukin 2 ◽  
Pituitary Cell ◽  
Receptor Expression ◽  
Interleukin 2 Receptor

Immunomodulatory Effects of Antipsychotic Drugs in Whole Blood Cell Cultures from Healthy Subjects

2020 ◽  
Vol 15 (4) ◽  
pp. 261-266
Author(s):  
Eun-Jeong Kim ◽  
Yong-Ku Kim
Keyword(s):  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Antipsychotic Drugs ◽  
Future Research ◽  
Immunomodulatory Effects ◽  
In Vitro Production ◽  
Therapeutic Concentration ◽  
Whole Blood Cell Cultures

Objective: We aimed to evaluate the effects of various antipsychotics on the in vitro production of C-reactive protein (CRP) in whole blood cell cultures from healthy volunteers. The evaluation was performed using haloperidol, quetiapine, clozapine, amisulpride, and chlorpromazine. Methods: Antipsychotic agents were added to the participants' whole blood samples, and the resulting CRP levels were measured. For each agent, three different concentrations were tested: the therapeutic concentration, one-tenth the therapeutic concentration, and ten times the therapeutic concentration. The differences in CRP concentrations before and after drug administration were investigated. Results: The Friedman test showed that haloperidol, amisulpride, and chlorpromazine significantly increased CRP levels in the blood culture samples; however, clozapine and quetiapine did not increase CRP levels. In the case of chlorpromazine, elevated CRP levels were noted at all concentrations tested. Conclusion: Our study suggests that some antipsychotics elevate CRP levels in vitro. These results agree with previous studies showing that antipsychotics have immunomodulatory effects. Future research will clarify our findings and our understanding of antipsychotic drugs and their impact on immune regulation.

Impaired cytokine production in whole blood cell cultures of patients with urological carcinomas

1993 ◽  
Vol 119 (7) ◽  
pp. 430-433 ◽  
Author(s):  
U. Elsässer-Beile ◽  
S. von Kleist ◽  
R. Fischer ◽  
M. Martin ◽  
U. Wetterauer ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Cultures ◽  
Whole Blood ◽  
Cytokine Production ◽  
Whole Blood Cell Cultures
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