scholarly journals Allogeneic gastric cancer cell-dendritic cell hybrids induce tumor antigen (carcinoembryonic antigen) specific CD8+ T cells

2005 ◽  
Vol 55 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Sachiko Matsumoto ◽  
Hiroaki Saito ◽  
Shunichi Tsujitani ◽  
Masahide Ikeguchi
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Dendritic Cell ◽  
Carcinoembryonic Antigen ◽  
Cancer Cell ◽  
Cd8 T Cells ◽  
Tumor Antigen ◽  
Gastric Cancer Cell ◽  
Cell Hybrids

scholarly journals High SLC2A1 expression associated with suppressing CD8 T cells and B cells promoted cancer survival in gastric cancer

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0245075
Author(s):  
Kyueng-Whan Min ◽  
Dong-Hoon Kim ◽  
Byoung Kwan Son ◽  
Kyoung Min Moon ◽  
So Myoung Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
B Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cd8 T Cells ◽  
Immune Cells ◽  
Gastric Cancer Cell ◽  
Glucose Transporter ◽  
Gastric Cancer Cell Lines

High expression of glucose transporter family members, which augment glucose uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation and survival of tumor cells, contributing to the energy supply, biosynthesis and homeostasis of cancer cells. Among the many members, solute carrier family 2 member 1 (SLC2A1) encodes a glucose transporter, GLUT1, that is critical in the metabolism of glucose, which is an energy source for cell growth that contributes to cancer progression and development. The aim of this study was to analyze the survival and genetic changes/immune profiles in patients with gastric cancer with high SLC2A1 expression and to provide treatment for improving prognosis. This study investigated the clinicopathologic parameters, the proportion of immune cells and gene sets affecting SLC2A1 expression in 279 and 415 patients with gastric cancer from the Eulji Hospital cohort and The Cancer Genome Atlas, respectively. We assessed the response to conventional chemotherapy drugs, including fluorouracil, a compound of fluoropyrimidine S-1, oxaliplatin, and all−trans−retinoic acid (ATRA), in gastric cancer cell lines with high SLC2A1 expression. High SLC2A1 expression was associated with poor prognosis, cancer cell proliferation, decreased immune cells, including CD8 T cells and B cells, and a low prognostic nutrition index, representing body nutrition-related status. In pathway network analysis, SLC2A1 was indirectly linked to the retinoic signaling pathway and negatively regulated immune cells/receptors. In the drug response analysis, the drug ATRA inhibited gastric cancer cell lines with high SLC2A1 expression. Treatment involving the use of SLC2A1 could contribute to better clinical management/research for patients with gastric cancer.

Tumor antigen-specific CD8+ T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer

2017 ◽  
Vol 313 ◽  
pp. 43-51 ◽  
Author(s):  
Xu Lu ◽  
Lin Yang ◽  
Daxing Yao ◽  
Xuan Wu ◽  
Jingpo Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Cd8 T Cells ◽  
Tumor Antigen ◽  
Human Gastric Cancer

scholarly journals Role of CD4+CD25+ Regulatory T Cells in Melatonin-Mediated Inhibition of Murine Gastric Cancer Cell Growth In Vivo and In Vitro

2011 ◽  
Vol 294 (5) ◽  
pp. 781-788 ◽  
Author(s):  
Hui Liu ◽  
Li Xu ◽  
Jian-En Wei ◽  
Mei-Rong Xie ◽  
Shi-E Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Regulatory T Cells ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth

scholarly journals The conventional dendritic cell 1 subset primes CD8+ T cells and traffics tumor antigen to drive anti-tumor immunity in the brain

2021 ◽  
Author(s):  
Jay A. Bowman-Kirigin ◽  
Brian T. Saunders ◽  
Rupen Desai ◽  
Anthony Z. Wang ◽  
Maximilian O. Schaettler ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Tumor Immunity ◽  
Cd8 T Cells ◽  
Tumor Antigen ◽  
Aminolevulinic Acid ◽  
Cervical Lymph Nodes ◽  
The Central Nervous System ◽  
Antigen Presenting

The central nervous system (CNS) antigen presenting cell (APC) which primes anti-tumor CD8+ T cell responses remains undefined. Elsewhere, the conventional dendritic cell 1 (cDC1) performs this role. However, steady-state brain cDC1 are rare; cDC localize to choroid plexus and dura. Using preclinical glioblastoma models and cDC1-deficient mice, we explored the role of cDC1 in CNS anti-tumor immunity. We determined that cDC1 mediate checkpoint blockade-induced survival benefit and prime neoantigen-specific CD8+ T cells against brain tumors. We observed that cDC, including cDC1, isolated from the tumor, the dura, and the CNS-draining cervical lymph nodes harbored a traceable fluorescent tumor-antigen. In patient samples, we observed several APC subsets (including the CD141+ cDC1-equivalent) infiltrating glioblastomas, meningiomas, and dura. In these same subsets, we identified a tumor-specific fluorescent metabolite of 5-aminolevulinic acid, which labels tumor cells during fluorescence-guided glioblastoma resection. Together, these data elucidate the specialized behavior of cDC1 and suggest cDC1 play a significant role in CNS anti-tumor immunity.

Sign in / Sign up

Export Citation Format

Share Document