scholarly journals Relationships between KRAS mutation status and baseline radiographic distribution of disease in patients with stage IV colorectal cancer

2014 ◽  
Vol 39 (6) ◽  
pp. 1261-1266 ◽  
Author(s):  
Michael H. Rosenthal ◽  
Kyung Won Kim ◽  
Charles S. Fuchs ◽  
Jeffrey A. Meyerhardt ◽  
Nikhil H. Ramaiya
Keyword(s):  
Colorectal Cancer ◽  
Kras Mutation ◽  
Stage Iv ◽  
Mutation Status ◽  
Stage Iv Colorectal Cancer ◽  
Kras Mutation Status

scholarly journals Discordance of KRAS Mutational Status between Primary Tumors and Liver Metastases in Colorectal Cancer: Impact on Long-Term Survival Following Radical Resection

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2148
Author(s):  
Francesco Ardito ◽  
Francesco Razionale ◽  
Lisa Salvatore ◽  
Tonia Cenci ◽  
Maria Vellone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Primary Tumor ◽  
Kras Mutation ◽  
Colorectal Tumor ◽  
Term Survival ◽  
Primary Tumors ◽  
Mutation Status ◽  
Primary Colorectal Tumor ◽  
Kras Mutation Status

If KRAS mutation status of primary colorectal tumor is representative of corresponding colorectal liver metastases (CRLM) mutational pattern, is controversial. Several studies have reported different rates of KRAS discordance, ranging from 4 to 32%. Aim of this study is to assess the incidence of discordance and its impact on overall survival (OS) in a homogenous group of patients. KRAS mutation status was evaluated in 107 patients resected for both primary colorectal tumor and corresponding CRLM at the same institution, between 2007 and 2018. Discordance rate was 15.9%. Its incidence varied according to the time interval between the two mutation analyses (p = 0.025; Pearson correlation = 0.2) and it was significantly higher during the first 6 months from the time of primary tumor evaluation. On multivariable analysis, type of discordance (wild-type in primary tumor, mutation in CRLM) was the strongest predictor of poor OS (p < 0.001). At multivariable logistic regression analysis, the number of CRLM >3 was an independent risk factor for the risk of KRAS discordance associated with the worst prognosis (OR = 4.600; p = 0.047). Results of our study suggested that, in the era of precision medicine, possibility of KRAS discordance should be taken into account within multidisciplinary management of patients with metastatic colorectal cancer.

scholarly journals Cigarette Smoking and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women

2012 ◽  
Vol 107 (5) ◽  
pp. 782-789 ◽  
Author(s):  
N J Samadder ◽  
Robert A Vierkant ◽  
Lori S Tillmans ◽  
Alice H Wang ◽  
Charles F Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Older Women ◽  
Kras Mutation ◽  
Colorectal Cancer Risk ◽  
Mutation Status ◽  
Kras Mutation Status

scholarly journals KRAS mutation status, comorbidity, and mortality in patients with metastatic colorectal cancer in Denmark

2018 ◽  
Vol 57 (12) ◽  
pp. 1727-1729
Author(s):  
Anne Gulbech Ording ◽  
Buket Öztürk ◽  
Karen-Lise Garm Spindler ◽  
Henrik Toft Sørensen ◽  
Margaret McCusker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Kras Mutation ◽  
Mutation Status ◽  
Kras Mutation Status

scholarly journals SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer

2019 ◽  
Vol Volume 12 ◽  
pp. 2115-2121 ◽  
Author(s):  
Ying Lv ◽  
Xin Wang ◽  
Lerong Liang ◽  
Lei Wang ◽  
Jie Lu
Keyword(s):  
Colorectal Cancer ◽  
Kras Mutation ◽  
Tumor Volume ◽  
Metabolic Tumor Volume ◽  
Mutation Status ◽  
Kras Mutation Status

DEPENDENCE OF YKL-40 mRNA TISSUE LEVELS ON KRAS MUTATION STATUS IN COLORECTAL CANCER - PRELIMINARY RESULTS

2015 ◽  
Vol 1 (2) ◽  
pp. 43 ◽  
Author(s):  
Yana Feodorova ◽  
Dessislava Tashkova ◽  
Kiril Simitchiev ◽  
Anton Todorov ◽  
Gancho Kostov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Kras Mutation ◽  
Mutation Status ◽  
Preliminary Results ◽  
Tissue Levels ◽  
Kras Mutation Status
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