scholarly journals Cigarette Smoking and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women

2012 ◽  
Vol 107 (5) ◽  
pp. 782-789 ◽  
Author(s):  
N J Samadder ◽  
Robert A Vierkant ◽  
Lori S Tillmans ◽  
Alice H Wang ◽  
Charles F Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Older Women ◽  
Kras Mutation ◽  
Colorectal Cancer Risk ◽  
Mutation Status ◽  
Kras Mutation Status

Diabetes Mellitus and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women

2011 ◽  
Vol 140 (5) ◽  
pp. S-354
Author(s):  
Anthony Razzak ◽  
Robert Vierkant ◽  
Alice Wang ◽  
Lori S. Tillmans ◽  
Charles F. Lynch ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Older Women ◽  
Kras Mutation ◽  
Colorectal Cancer Risk ◽  
Mutation Status ◽  
Kras Mutation Status

Alcohol Intake and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women

2011 ◽  
Vol 140 (5) ◽  
pp. S-353
Author(s):  
Anthony Razzak ◽  
Robert Vierkant ◽  
Alice Wang ◽  
Lori S. Tillmans ◽  
Charles F. Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Older Women ◽  
Kras Mutation ◽  
Alcohol Intake ◽  
Colorectal Cancer Risk ◽  
Mutation Status ◽  
Kras Mutation Status

Abstract 1891: Cigarette smoking and incident colorectal cancer by KRAS mutation status in a population-based cohort of older women

2011 ◽  
Author(s):  
Niloy Jewel Samadder ◽  
Robert A. Vierkant ◽  
Alice Wang ◽  
Lori S. Tillmans ◽  
Charles F. Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cigarette Smoking ◽  
Older Women ◽  
Kras Mutation ◽  
Population Based ◽  
Mutation Status ◽  
Kras Mutation Status

Abstract 1892: Folate intake and incident colorectal cancer by KRAS mutation status in a population-based cohort of older women

2011 ◽  
Author(s):  
Anthony Razzak ◽  
Robert A. Vierkant ◽  
Alice H. Wang ◽  
Lori S. Tillmans ◽  
Charles F. Lynch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Older Women ◽  
Kras Mutation ◽  
Population Based ◽  
Folate Intake ◽  
Mutation Status ◽  
Kras Mutation Status

scholarly journals Discordance of KRAS Mutational Status between Primary Tumors and Liver Metastases in Colorectal Cancer: Impact on Long-Term Survival Following Radical Resection

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2148
Author(s):  
Francesco Ardito ◽  
Francesco Razionale ◽  
Lisa Salvatore ◽  
Tonia Cenci ◽  
Maria Vellone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Primary Tumor ◽  
Kras Mutation ◽  
Colorectal Tumor ◽  
Term Survival ◽  
Primary Tumors ◽  
Mutation Status ◽  
Primary Colorectal Tumor ◽  
Kras Mutation Status

If KRAS mutation status of primary colorectal tumor is representative of corresponding colorectal liver metastases (CRLM) mutational pattern, is controversial. Several studies have reported different rates of KRAS discordance, ranging from 4 to 32%. Aim of this study is to assess the incidence of discordance and its impact on overall survival (OS) in a homogenous group of patients. KRAS mutation status was evaluated in 107 patients resected for both primary colorectal tumor and corresponding CRLM at the same institution, between 2007 and 2018. Discordance rate was 15.9%. Its incidence varied according to the time interval between the two mutation analyses (p = 0.025; Pearson correlation = 0.2) and it was significantly higher during the first 6 months from the time of primary tumor evaluation. On multivariable analysis, type of discordance (wild-type in primary tumor, mutation in CRLM) was the strongest predictor of poor OS (p < 0.001). At multivariable logistic regression analysis, the number of CRLM >3 was an independent risk factor for the risk of KRAS discordance associated with the worst prognosis (OR = 4.600; p = 0.047). Results of our study suggested that, in the era of precision medicine, possibility of KRAS discordance should be taken into account within multidisciplinary management of patients with metastatic colorectal cancer.

Expression of p27Kip1and bcl-2, cigarette smoking, and colorectal cancer risk

Biomarkers ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. 225-234 ◽  
Author(s):  
Naoko Ishibe ◽  
Andrew N. Freedman ◽  
Arthur M. Michalek ◽  
Christine Iacobuziodonahue ◽  
Curtis J. Mettlin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Colorectal Cancer Risk

scholarly journals KRAS mutation status, comorbidity, and mortality in patients with metastatic colorectal cancer in Denmark

2018 ◽  
Vol 57 (12) ◽  
pp. 1727-1729
Author(s):  
Anne Gulbech Ording ◽  
Buket Öztürk ◽  
Karen-Lise Garm Spindler ◽  
Henrik Toft Sørensen ◽  
Margaret McCusker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Kras Mutation ◽  
Mutation Status ◽  
Kras Mutation Status
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