Anastomosis of the umbilical arteries: physiologic variant or complication of umbilical catheterization?

1997 ◽  
Vol 27 (7) ◽  
pp. 618-619
Author(s):  
Martin Krause ◽  
Barbara Engelhardt
Keyword(s):  
Umbilical Catheterization ◽  
Umbilical Arteries

Ultrastructure of the Omphalomesenteric Duct Rest in the Umbilical Cord at Term

1982 ◽  
Vol 40 ◽  
pp. 250-251
Author(s):  
B. A. Clark ◽  
T. Okagaki
Keyword(s):  
Umbilical Cord ◽  
Umbilical Vein ◽  
Meckel’S Diverticulum ◽  
Meckel's Diverticulum ◽  
Columnar Epithelium ◽  
Omphalomesenteric Duct ◽  
Umbilical Arteries

Vestiges of the omphalomesenteric or vitello-intestinal duct and the pathologic implications attributed to these remnants have been treated in great detail by several investigators. Persistence of the omphalomesenteric duct is associated with such conditions as Meckel's diverticulum, umbilical fistula, mucosal polyps, and sinuses or cysts of the umbilicus. Remnants of the duct in the umbilical cord, although infrequent, are located outside of the triangle formed by the two umbilical arteries and the umbilical vein, are usually discontinuous and are often represented by a small lumen lined by cuboidal or columnar epithelium. This study will examine the ultrastructure of these cells.

Doppler measurements of both umbilical arteries do not improve predictive value for adverse perinatal outcomes in small-for-gestational age fetuses

2018 ◽  
Vol 231 ◽  
pp. 169-173
Author(s):  
Charlotte A. Vollgraff Heidweiller-Schreurs ◽  
Ninieck E. van Maasakker ◽  
Peter M. van de Ven ◽  
Christianne J.M. de Groot ◽  
Caroline J. Bax ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Predictive Value ◽  
Perinatal Outcomes ◽  
Adverse Perinatal Outcomes ◽  
Umbilical Arteries

scholarly journals Evidence from human placenta, ER-stressed trophoblasts and transgenic mice links transthyretin proteinopathy to preeclampsia

2022 ◽  
Author(s):  
Shibin Cheng ◽  
Zheping Huang ◽  
Sayani Banerjee ◽  
Joel Buxbaum ◽  
Surendra Sharma
Keyword(s):  
Transgenic Mice ◽  
Intrauterine Growth Restriction ◽  
Caspase 3 ◽  
Kidney Injury ◽  
Wild Type ◽  
Junctional Zone ◽  
Intrauterine Growth ◽  
Pregnant Mice ◽  
Umbilical Arteries ◽  
Trophoblast Cell Line

We have demonstrated that protein aggregation plays a pivotal role in the pathophysiology of preeclampsia (PE) and identified several aggregated proteins in the circulation of PE patients, most significantly the serum protein transthyretin (TTR). Here we show robust accumulation of TTR aggregates in the placentas of women with early-onset PE (e-PE). TTR aggregation was inducible in primary human trophoblasts (PHTs) and the TCL-1 trophoblast cell line by ER stress inducers or autophagy-lysosomal disruptors. Hypoxia/reoxygenation (H/R) of cultured PHTs increased intracellular BiP, phosphorylated IRE1alpha, PDI and Ero-1, all markers of the UPR, and the apoptosis mediator caspase-3. Blockade of IRE1alpha inhibited H/R-induced upregulation of Ero-1 in PHTs. Excessive UPR was observed in the PE placenta. Further, pregnant mice, overexpressing transgene encoded wild type human TTR, displayed aggregated TTR in the junctional zone of the placenta and PE-like features including hypertension, proteinuria, intrauterine growth restriction, kidney injury, and elevated levels of the PE biomarkers serum sFlt-1 and endoglin. High Resolution Ultrasound analysis revealed low blood flow in uterine and umbilical arteries compared to that found in wild type pregnant mice. On the other hand, loss of mouse TTR function did not cause any pregnancy abnormalities in Ttr-/- mice. These observations in the PE placenta, cultured trophoblast cells and TTR transgenic mice indicate that TTR aggregation is an important causal contributor to PE pathophysiology.

scholarly journals Changes in Umbilical and Cerebral Blood Flow in Pregnancies Diagnosed with Clinical Chorioamnionitis. Is Chorioamnionitis Predictable?

2019 ◽  
pp. 1
Author(s):  
Berfin Okmen Ozkan ◽  
Emre Ekmekci
Keyword(s):  
Umbilical Artery ◽  
Demographic Data ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Significant Difference ◽  
Umbilical Artery Doppler ◽  
Doppler Evaluation ◽  
Umbilical Arteries

<p><strong>Objective:</strong> To evaluate the predictability of clinical chorioamnionitis by Doppler changes in fetal middle cerebral and umbilical arteries, at hospitalized patients due to preterm premature rupture of membranes.</p><p><strong>Study Design:</strong> Patients who were admitted and hospitalized due to preterm premature rupture of membranes between 24 weeks and 33 weeks and 6 days pregnancies are included in the study. Demographic data of patients, gestational age at referring to hospitalization, fetal presentation at admission, delivery time, delivery indications and total follow-up time until delivery of each case were recorded.</p><p><strong>Results:</strong> A total of 108 patients were evaluated retrospectively. The rate of clinical chorioamnionitis was 5.55% (6/108). There was no significant difference between pregnancies terminated with the diagnosis of clinical chorioamnionitis and pregnancies terminated with other indications in terms of the maximum systolic velocity at middle cerebral artery and umbilical artery pulsatility indices.</p><p><strong>Conclusion:</strong> Clinical chorioamnionitis is a serious complication and is more common in patients being followed up after preterm premature rupture of membranes. Although it is crucial to be predicted due to neonatal worse prognosis, it cannot be predicted by middle cerebral and umbilical artery Doppler evaluation.</p>

scholarly journals Histomorphometric Analysis of Umbilical Arteries in Preeclampsia

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Saleena N Ali ◽  
◽  
Suma H Y ◽  
Yogesh Ashok Sontakke ◽  
Dilip Kumar Maurya ◽  
...  
Keyword(s):  
Histomorphometric Analysis ◽  
Umbilical Arteries
Sign in / Sign up

Export Citation Format

Share Document