Increased calcium oxalate crystal nucleation and aggregation by peroxidized protein of human kidney stone matrix and renal cells

2001 ◽  
Vol 29 (3) ◽  
pp. 194-198 ◽  
Author(s):  
A. Govindaraj ◽  
R. Selvam
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Human Kidney ◽  
Crystal Nucleation ◽  
Renal Cells ◽  
Calcium Oxalate Crystal ◽  
Stone Matrix

Simultaneous measurements of calcium oxalate crystal nucleation and aggregation: impact of various modifiers

1995 ◽  
Vol 23 (4) ◽  
pp. 231-238 ◽  
Author(s):  
B. Hess ◽  
U. Meinhardt ◽  
L. Zipperle ◽  
R. Giovanoli ◽  
P. Jaeger
Keyword(s):  
Calcium Oxalate ◽  
Crystal Nucleation ◽  
Calcium Oxalate Crystal ◽  
Simultaneous Measurements

Second Prize:Comprehensive Proteomic Analysis of Human Calcium Oxalate Monohydrate Kidney Stone Matrix

2008 ◽  
Vol 22 (6) ◽  
pp. 1161-1168 ◽  
Author(s):  
Benjamin K. Canales ◽  
Lorraine Anderson ◽  
Leeann Higgins ◽  
Joel Slaton ◽  
Ken P. Roberts ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Proteomic Analysis ◽  
Kidney Stone ◽  
Calcium Oxalate Monohydrate ◽  
Stone Matrix

scholarly journals Urinary calcium oxalate crystal growth inhibitors.

1994 ◽  
Vol 5 (5) ◽  
pp. S46
Author(s):  
E M Worcester
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Bone Matrix ◽  
Urinary Calcium ◽  
Crystal Nucleation ◽  
Calcium Oxalate Crystal ◽  
Stone Formers ◽  
High Concentrations ◽  
Renal Tubular

Calcium stones occur because renal tubular fluid and urine are supersaturated with respect to calcium oxalate and phosphate. The process of stone formation includes crystal nucleation, growth, aggregation, and attachment to renal epithelia. Urine contains macromolecules that modify these processes and may protect against stone formation. Attention has focused especially on inhibitors of crystal growth, and several have been isolated from urine, including nephrocalcin, an acidic phosphorylated glycoprotein that contains several residues of gamma-carboxyglutamic acid per molecule; osteopontin (uropontin), a phosphorylated glycoprotein also found in bone matrix; uronic acid-rich protein, which contains a covalently bound glycosaminoglycan residue; and several others. Abnormalities in structure and/or function have been detected in some of these proteins in stone formers' urine. However, the overall ability of urinary macromolecules to inhibit calcium oxalate crystal growth is often normal in stone formers. Recently, attention has been focused on the ability of these molecules to inhibit other stages in stone formation. Nephrocalcin can inhibit crystal nucleation, for example, and both nephrocalcin and Tamm-Horsfall protein inhibit crystal aggregation. Nephrocalcin and Tamm-Horsfall protein from stone formers are less active in preventing aggregation, and under some conditions, Tamm-Horsfall protein may promote the formation of crystal aggregates, especially in the presence of high concentrations of calcium. The structural abnormalities responsible for impaired inhibitory activity are not completely understood.

2070 DEVELOPMENT OF DROSOPHILA KIDNEY STONE MODEL AND REAL-TIME VISUALIZATION OF CALCIUM OXALATE CRYSTAL FORMATION

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Taku Hirata ◽  
Pablo Cabrero ◽  
Dan Bondeson ◽  
Donald Berkholz ◽  
Erik Ritman ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Real Time ◽  
Kidney Stone ◽  
Crystal Formation ◽  
Calcium Oxalate Crystal ◽  
Real Time Visualization

Human kidney stone matrix proteins alleviate hyperoxaluria induced renal stress by targeting cell-crystal interactions

Life Sciences ◽  
2020 ◽  
Vol 262 ◽  
pp. 118498
Author(s):  
Shifa Narula ◽  
Simran Tandon ◽  
Dhruv Kumar ◽  
Swati Varshney ◽  
Khushboo Adlakha ◽  
...  
Keyword(s):  
Kidney Stone ◽  
Human Kidney ◽  
Matrix Proteins ◽  
Stone Matrix
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